2-Hydroxyisocaproic acid: A novel in vitro protease activity modulator with potential benefits for arthritis treatment
Main Article Content
Abstract
Osteoarthritis affects approximately half a billion people worldwide and creates a significant economic burden, accounting for up to 2.5% of the national gross domestic product. Despite extensive research, a disease-modifying osteoarthritis drug remains unavailable. 2-hydroxyisocaproic acid is a physiological substance and the 2-hydroxy analogue of the essential amino acid leucine. This study investigates the potential of 2-hydroxyisocaproic acid to down-regulate key proteases involved in articular cartilage degradation. Specifically, we explore the use of 2-hydroxyisocaproic acid to inhibit the activity of matrix metalloproteinase 13 and a disintegrin and metalloproteinase with thrombospondin motifs 5, aiming to reduce the degradation of type II collagen and aggrecan, respectively, in osteoarthritis. Our findings demonstrate that 2-hydroxyisocaproic acid modulates and reduces the activity of both matrix metalloproteinase 13 and a disintegrin and metalloproteinase with thrombospondin motifs 5. Notably, 2-hydroxyisocaproic acid’s reversible inhibition of these enzymes does not involve covalent bonding, positioning it as an enzyme modulator or down-regulator rather than a direct inhibitor.
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How to Cite
KARILA, Tuomo et al.
2-Hydroxyisocaproic acid: A novel in vitro protease activity modulator with potential benefits for arthritis treatment.
Medical Research Archives, [S.l.], v. 12, n. 7, july 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/5468>. Date accessed: 21 dec. 2024.
doi: https://doi.org/10.18103/mra.v12i7.5468.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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