Current Concepts of Leukemic Stem Cells: Origin, Characteristics, and its Clinical Implications in Acute Myeloid Leukemia
Main Article Content
Abstract
Despite significant advancements in therapy, patients diagnosed with acute myeloid leukemia (AML) continue to face poor outcomes, often experiencing relapses even after achieving initial complete remission. The occurrence of relapse is attributed to the inability of conventional treatment to eliminate a specific subset of cells within the bone marrow known as leukemic stem cells (LSCs). These specialized cells exhibit self-renewal capacity and have the ability to proliferate and differentiate into leukemic blasts. The accumulation of multiple genetic mutations in LSCs makes them resistant to standard chemotherapy. Several studies have been conducted to identify the phenotypic characteristics and genetic signatures of LSCs, with the aim of differentiating them from normal hematopoietic stem cells (HSCs). Understanding the role of LSCs in AML treatment resistance has paved the way for the development of targeted and more precise treatments, especially for relapsed AML patients, without affecting the healthy HSCs. This review elaborates on the origin, phenotypic and genotypic characteristics of LSCs, and their role in the biology of AML, with a brief note on therapies targeting LSCs.
Keywords:
acute myeloid leukemia, leukemic stem cells, immunophenotype, targeted therapy, relapsed AML
Article Details
How to Cite
SIVAKUMAR, Visaali; RAVI, Soundarya; MANIVANNAN, Prabhu.
Current Concepts of Leukemic Stem Cells: Origin, Characteristics, and its Clinical Implications in Acute Myeloid Leukemia.
Medical Research Archives, [S.l.], v. 12, n. 6, june 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/5517>. Date accessed: 02 july 2024.
doi: https://doi.org/10.18103/mra.v12i6.5517.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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