Abstract
Background: Tendon and ligament disorders particularly those of the weight bearing joints are associated with decreased physical activities affecting the quality of life. Current management includes conservative and surgical approaches requires a relatively long recovery time, in addition to the post-operative complications such as infection of the wound site and joint stiffness if managed surgically. Connective tissue growth factor is a type of growth factor expressed during second phase of the healing process and is responsible for tissue healing by stimulating the release of extracellular matrix responsible for tissue healing. Hence, the objective of this review is to identify available studies relating to the used of connective tissue growth factor in tissue culture for tendon and ligament healing.
Methods: Studies were identified from PubMed Central, BioMed Central, ScienceDirect, and Wiley Online Library with the keywords: Connective Tissue Growth Factor ‘OR’ CTGF ‘OR’ CCN ‘AND’ Regeneration ‘AND’ Healing from the year 2019 to present, 2024. All literatures were reviewed in three phases by two reviewers.
Results and Conclusion: There were only three articles which met our inclusion criteria. In general, connective tissue growth factor had been reported to be beneficial for ligament and tendon regeneration. However, the effective connective tissue growth factor dose for optimal ligament and tendon regeneration healing could not be determined due to the different cell source and delivery methods utilised among the identified articles.
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