Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes

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Published Jul 31, 2024
DOI: https://doi.org/10.18103/mra.v12i7.5598

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Main Article Content

Prídavková Zuzana, MUDr
UVEA Eye Clinic s. r. o., Martin, Slovakia; Department of Ophthalmology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia; Department of Ophthalmology, Central Military Hospital, Ružomberok, Slovakia
Alena Furdová, prof. MUDr
Department of Ophthalmology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia
Plank Lukáš, prof. MUDr
Martin´s Biopsy Centre, Ltd., Martin, Slovakia;  Department of Pathological Anatomy, Jessenius Faculty of Medicine and University Hospital in Martin, Comenius University in Bratislava, Slovakia
Žiak Peter, MUDr, PhD
UVEA Eye Clinic s. r. o., Martin, Slovakia; Eye Clinic, Jessenius Faculty of Medicine, Martin, Slovakia
Halička Juraj, MUDr, PhD
UVEA Eye Clinic s. r. o., Martin, Slovakia; Eye Clinic, Jessenius Faculty of Medicine, Martin, Slovakia
Benca-Kapitánová Karolína, MUDr, PhD
UVEA Eye Clinic s. r. o., Martin, Slovakia
Vida Rastislav, MUDr
UVEA Eye Clinic s. r. o., Martin, Slovakia
Bartoš Vladimír, MUDr, PhD
Martin´s Biopsy Centre, Ltd., Martin, Slovakia

Abstract

Background


The purpose of this paper was to evaluate the association of the Bcl-2 protein, Ki-67 antigen expression and the apoptotic index with biological behaviour of basal cell carcinoma.


Methods


Combined analysis of retrospective and prospective study of data from two centres over a period of years 2008–2023 on histologically confirmed basal cell carcinoma without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.


Results


The study cohort included 66 patients with 68 basal cell carcinomas of the eyelids (n = 68). The median age was 68 years. Resection margins < 2 mm were in 33.9 %, without any connection to recurrence rate (p = 0.076). Average value of Bcl-2 expression in non-aggressive types was 82.65 % (p = 0.000). The value of Ki-67 expression in patients with non-aggressive tumours amounted to 35.49 % (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In two cases, the orbital exenteration was carried out (0.03 %). In one case was administered biological therapy. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 cases (0.06 %).


Conclusion


New information on cancer biomarkers in basal cell carcinoma contribute to choosing a correct therapy with achieving good aesthetic results and a good survival rate. 


Key words: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology

Keywords: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology

Article Details

How to Cite
ZUZANA, Prídavková et al. Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes. Medical Research Archives, [S.l.], v. 12, n. 7, july 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5598>. Date accessed: 05 aug. 2024. doi: https://doi.org/10.18103/mra.v12i7.5598.
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Issue
Vol 12 No 7 (2024): Vol 12 No 7 (2024): July issue
Section
Research Articles

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