Abstract
Introduction:
Worldwide diffused β cell lymphoma is the commonest type of non-Hodgkin lymphoma about 31% of all non-Hodgkin Lymphoma. Median age reported for diffuse large β-cell lymphoma 60 to 70 years of age. Extra nodal diffuse large β-cell lymphoma reported in about 30% cases and most common site were found gastrointestinal tract skin and soft tissue bone or Genito urinary tract, head and neck region. Extra nodal non-Hodgkin lymphoma only represented in 10% cases.
Case Study:
Patients presented with complaint of focal neurological deficit vomiting, headache nausea and status seizures with behavioural and mental change and 27-year-old male presented with difficulty pain while walking for last 1.5 months.
Discussion:
Musculoskeletal Lymphomas are predominantly a manifestation of lymphoma dissemination. Extra nodal Lymphomas commonly involved skin, head and neck and gastrointestinal tract. Lymphomas rarely involved skeletal system. Most common radiological finding with Extra-Nodal lymphoma are blastic lesion and lytic lesion, sometimes mixed lesion with lytic and blastid. Primary central nervous system lymphoma usually originates from cerebellum, spinal cord, Pia matter, Retina or optic nerve. Manifestation of lymphoma in skeletal muscles is rare, usually they involve gluteal muscles and pelvis.
Conclusion:
Primary Central Nervous System (CNS) Lymphoma often misdiagnosed as Brain tumour and this delays proper treatment and confirmation of diagnosis. Immunohisto-chemistry examination is mandatory to achieve confirm diagnosis.