Chest computed tomography and lung function one year following COVID-19 pneumonia

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Published Sep 30, 2024
DOI: https://doi.org/10.18103/mra.v12i9.5671

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Main Article Content

Marie Pierre Debray
AP-HP, Service de radiologie, Hôpital Bichat, Paris, France ; Inserm UMR 1152, Paris, France
Pauline Balagny
AP-HP, Service de Physiologie Explorations Fonctionnelles, Hôpital Bichat, Paris, France; Université Paris Cité, Population-based Cohorts Unit, INSERM, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, UMS 011, Paris
Camille Taille
Inserm UMR 1152, Paris, France;  Université Paris-Cité, UFR de Médecine, Paris, France; AP-HP, Service de pneumologie, Centre de référence des Maladies Pulmonaires Rares, Hôpital Hospital, Paris, France
Sacha Rozencwajg
Université Paris-Cité, UFR de Médecine, Paris, France; Hôpital Bichat, AP-HP, Département d’Anesthésie et de Réanimation, Paris, France 
Etienne de Montmollin
AP-HP, Medical and Infectious Diseases Intensive Care Unit, Bichat Hospital, Paris, France; UMR 1137, IAME, Université Paris Cité, Paris, France
Lynn Ezzeddine
AP-HP, Service de radiologie, Hôpital Bichat, Paris, France
Christophe Rioux
AP-HP, Service des Maladies Infectieuses et Tropicales, Hôpital Bichat, Paris, France
Josephine Landauer
AP-HP, Service de radiologie, Hôpital Bichat, Paris, France
Jade Ghosn
UMR 1137, IAME, Université Paris Cité, Paris, France; AP-HP, Service des Maladies Infectieuses et Tropicales, Hôpital Bichat, Paris, France
Catherine Bancal
AP-HP, Service de Physiologie Explorations Fonctionnelles, Hôpital Bichat, Paris, France
Antoine Khalil
AP-HP, Service de radiologie, Hôpital Bichat, Paris, France; Inserm UMR 1152, Paris, France; Université Paris-Cité, UFR de Médecine, Paris, France

Abstract

Objectives: To characterise chest CT abnormalities one year following severe-to-critical COVID-19 pneumonia, assess their functional significance and analyse the time-course of CT signs.


Methods: Retrospective observational monocentric study. Chest CT analysis of residual pulmonary opacities in patients having one year follow-up CT (between February 2021 and February 2022) after severe-to-critical COVID-19 pneumonia. Opacities were categorized into fibrotic-like and predominant ground-glass opacities and compared to pulmonary function tests. Sequential analysis of decreasing, stable or increasing signs at 3, 6, 12 and up to 24 months.


Results: One-year pulmonary opacities were present in 46 out of the 66 included patients, and were more frequent in patients admitted as compared to those not admitted to the intensive care unit (38/48, 79% versus 8/18, 44%, p=0.006), with an extent correlated to the length of ICU stay. Pulmonary function tests abnormalities were present in 24/29 patients (82.8%) having fibrotic-like residual opacities versus 6/13 patients (46.1%) having predominant ground-glass opacities (p=0.015). Bronchial distortions decreased in 29% of patients between 6 and 12 months, but CT abnormalities remained mostly stable thereafter in the 16 patients having follow-up CT up to 2 years.


Conclusion: One-year pulmonary opacities are more frequent in patients admitted to ICU as compared to non-ICU patients following severe-to-critical COVID-19 and seem related to the length of ICU stay. Fibrotic-like residual opacities are frequently associated to functional impairment.

Article Details

How to Cite
DEBRAY, Marie Pierre et al. Chest computed tomography and lung function one year following COVID-19 pneumonia. Medical Research Archives, [S.l.], v. 12, n. 9, sep. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5671>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.18103/mra.v12i9.5671.
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Vol 12 No 9 (2024): Vol 12 No 9 (2024): September ISSUE, Issue 9, VOl.12
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Research Articles

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