B-cell maturation in angioimmunoblastic T cell lymphoma (AITL): Development of secondary diffuse large B cell lymphoma (DLBCL) is likely associated with Attygalle patterns II and III
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Abstract
The pathology of an inguinal lymph node, diagnosed as angioimmunoblastic T cell lymphoma (AITL) with secondary development of EB virus (EBV)-related diffuse large B cell lymphoma (DLBCL), is analyzed in detail. The AITL lymph node was divided into three pathological areas, A, B, and C, corresponding to Attygalle Patterns I, II, and III. Development of DLBCL was observed at the areas B-C boundaries, corresponding to Patterns II and III. This likely indicated excessive B-cell maturation by neoplastic follicular helper T (TFH) cells. Although the mechanisms of DLBCL development in AITL are unclear, B-cell maturation is likely enhanced by neoplastic TFH, leading to germinal center disruption. Attygalle’s patterns are important in evaluating both T-cell and B-cell activities.
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