Faulty predictions by computer simulation may have promoted ineffective public health policies during COVID-19

Main Article Content

Dr. Jose-Luis Sagripanti

Abstract

The world has witnessed many epidemics in the past, some caused by other coronaviruses; and virus in this family cause 15% - 20% of all upper respiratory infections in humans, even in the absence of epidemics. SARS-CoV-2 (the causative agent of COVID-19) had a mortality much lower than those viruses of relevance in biodefense and a sensitivity to environmental sunlight inactivation higher than influenza virus.


The goal of this article was two-fold: a) to provide an answer to what turned a pandemic caused by a rather ordinary virus into an extraordinary public health crisis and b) whether the public health measures elicited by the predictions made by computer simulation were effective. Responding to these questions resulted in unexpected findings regarding the effectiveness of lock-downs and curfews, use of face masks, mandating social distancing and ordering massive vaccination campaigns.


The present work consolidates the most reliable epidemiological data gathered by international databases and governments of several countries with data from pertinent previous publications listed in References.


The data summarized in this article indicates that unusually restrictive measures were mandated largely in response to predictions made by computer modeling of the pandemic. In particular, the predictions reported by the WHO Collaborating Centre for Infectious Disease Modeling, of the prestigious Imperial College of London, projected that without drastic intervention (like lock downs and quarantines), 7 billion infections worldwide and 40 million deaths during 2020 alone. These figures are compared in this article with actual data reported during 2020 and at the end of the pandemic (2023) demonstrating that computer predictions of the evolution of the pandemic were a blunder with catastrophic global consequences.


The analysis in this study corroborates the stational progression of the pandemic which explain why measures intended to prevent person-to-person transmission of the disease (like lock-downs, wearing face masks, and social distancing) should have failed in containing COVID-19. This notion is supported by presented data on the ineffectiveness of lock-downs, use of face masks, and social distancing in selected countries.


The lower mortality registered in developing countries in comparison to developed countries where more hospital beds and respirators were employed, suggests that hospital infections resulting from intensive medical intervention and not SARS-Co V-2 could have accounted for the majority of deaths among patients otherwise healthy and without compounding health conditions.


The data discussed here indicates also that a variety of different experimental vaccines failed to prevent infections among selected countries of South America, and that instead, natural attenuation and progressively less invasive hospital procedures could account for the eventual ending of the pandemic.


Potential lessons to be drawn from the mismanagement of COVID-19 and preventive measures to instrument before the next pandemic are proposed at the end of the article.

Keywords: COVID-19, SARS-Co V-2, pandemic, computer simulation, lock-downs, face mask, social distancing, COVID-19 vaccination, COVID-19 mortality, coronaviruses, viral sunlight inactivation

Article Details

How to Cite
SAGRIPANTI, Dr. Jose-Luis. Faulty predictions by computer simulation may have promoted ineffective public health policies during COVID-19. Medical Research Archives, [S.l.], v. 12, n. 9, sep. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5809>. Date accessed: 04 oct. 2024. doi: https://doi.org/10.18103/mra.v12i9.5809.
Section
Research Articles

References

1. Kaplan, J., Frias, L. and McFall, M. A Third of the Global World Population Is in Coronavirus Lockdown. 2020. https://news.yahoo.com/countries-lockdown-because-coronavirus-183100697.html

2. Sandford, A. Coronavirus: Half of Humanity Now on lockdown as 90 Countries Call for Confinement. 2020. Euronews. https://yournews.com/2020/04/02/1544253/coronavirus-half-of-humanity-now-on-l ockdown-as-90-countries/

3. McNeil, W.H. Plagues and Peoples. 1977. Doubleday Publishing Group, New York.

4. Peiris, J.S.M., Lai, S.T., Poon, L.L.M., Guan, Y, Yam, L.Y.C., Lim, W., Nicholls, J., Yee, W.K.S., Yan, W.W., Cheung, M.T., Cheng, V.C.C., Chan, K.H., Tsang, D.N.C., Yung, R.W.H., Ng, T.K. and Yuen, K.Y. Coronavirus as a Possible Cause of Severe Acute Respiratory Syndrome. 2003. Lancet, 361, 1319-1325. https://doi.org/10.1016/S0140-6736(03)13077-2

5. Ramadan, N., Shaib, H. Middle East Respiratory Syndrome Corona Virus (MERS-CoV): A Review. 2019. Germas, 9, 35-42. https://doi.org/10.18683/germs.2019.1155

6. Holmes, K.V. Coronaviridae and Their Replication. In: Fields, B.N. and Knipe, D.M., Eds., Fields Virology, 1990. Second Edition, Chapter 29, Raven Press, New York, 841-856.

7. Jahrling, P.B. Viral Hemorrhagic Fevers. In: Zajtchuk, R., Ed., Textbook of Military Medicine, Medical Aspects of Chemical and Biological Warfare, Warfare, Weaponry and the Casualty, Part I, Chapter 29. 1997. Office of the Surgeon General Publications, Washington D.C., 591-602.

8. John’s Hopkins’ Center for System Sciences and Engineering. Coronavirus Statistics. Stats real time. 2020. https://epidemic-stats.com/

9. Browne, E. Fauci Was 'Untruthful' to Congress About Wuhan Lab Research, New Documents Appear To Show. US Congress meetings. Published September 9, 2021 https://www.congress.gov/117/meeting/house/114270/documents/HHRG-117-GO24-20211201-SD004.pdf

10. Newsweek. Fauci Was 'Untruthful' to Congress About Wuhan Lab Research. Published Sep 9, 2021. https://www.newsweek.com/fauci-untruthful-congress-wuhan-lab-research-documents-show-gain-function-1627351

11. The Scientist. NIH Cancels Funding for Bat Coronavirus Research Project. Published April 28, 2020 https://www.ncbi.nlm.nih.gov/search/research-news/9563/

12. Johnson, N.P., Mueller, J. Updating the accounts: global mortality of the 1918 –1920 “Spanish” influenza pandemic. 2002. Bull. Hist. Med. 76: 105–115.

13. Taubenberger, J.K., Reid, A.H., Krafft, A.E., Bijwaard, K.E., Fanning,T.G. Initial genetic characterization of the 1918 “Spanish” influenza virus. 1997. Science 275:1793–1796.

14. Tumpey, T.M., et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. 2005. Science 310:77– 807.

15. Zhang, S., Diao, M., Yu, W., Pei, L., Lin, Z., Chen, D. Estimation of the reproductive number of novel coronavirus (COVID-19) and the probable outbreak size on the Diamond Princess cruise ship: a data-driven analysis. 2020. Int J Infect Dis 93:201 –204. https://doi.org/10.1016/j.ijid.2020.02.033 [PMC free article] [PubMed] CrosRef] [Google Scholar]

16. Li, Q., Guan, X., Wu, P., et al. 2020. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus. Infected Pneumonia March 26, 2020. 2020. N Engl J Med 382:1199-1207 DOI: 10.1056/ NEJMoa2001316https://www.nejm.org/doi/full/10.1056/NEJMOa2001316

17. Sagripanti, J-L., Lytle, D. Estimated inactivation of corona viruses with special reference to COVID-19. 2020. Photochemistry & Photobiology Jul;96(4) :731-737. doi: 10.1111/php.13293. Epub 2020 Jul 9.

18. Tufekci, Z. Don’t Believe the COVID-19 Models. That’s not what they’re for. April 2 2020. https://www.theatlantic.com/technology/archive/2020/04/coronavirus-models-arent-supposed-be-right/609271/ Retrieved June 1 2020.

19. Flajnik, M., Singh, N.J., Holland, S.M. Fundamental Immunology. Eighth Edition. 2022.

20. Celentano, D.D., Szklo, M. Gordis Epidemiology. 6th Ed. 2018

21.Ferguson, N.M., Laydon, D., Nedjati-Gilani, G., Imai, N., Ainslie, K., Baguelin, M., Bhatia, S., Boonyasiri, A., Cucunubá, Z., Cuomo-Dannenburg, G., Dighe, A., Dorigatti, I., Fu, H., Gaythorpe, K., Green, W., Hamlet, A., Hinsley, W., Okell, L.C., van Elsland, S., Thompson, H., Verity, R., Volz, E., Wang H, Wang Y, Walker PGT, Walters C, Winskill P, Whittaker C, Donnelly CA, Riley S and Ghani AZ. Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand. 2020. Rep. 9, The Royal Society. https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf

22. Patrick, G.T., Walker, P.G.T., Whittaker, C., Watson, O., et al. 2020 Report 12 - The global impact of COVID-19 and strategies for mitigation and suppression. 26 March 2020. Retrieved March 28 and June 1 2020. https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-12-global-impact-covid-19/

23. Scher, I. Without any interventions like social distancing, one model predicts the coronavirus could have killed 40 million people this year. March 27 2020. https://www.businessinsider.com/covid19-model-predicts-40-million-people-could-die-without-interventions-2020-3 ))

24. Cheng, C., Barceló, J., Hartnett, S., Kubinec, R., Messerschmidt, L. COVID-19 Government Response Event Dataset (CoronaNet v.1.0) Nature Human Behaviour. 23 June 2020 https://www.nature.com/articles/s41562-020-0909-7

25. Begley, S. Influential Covid-19 model uses flawed methods and shouldn’t guide U.S. policies, critics say. April 17, 2020. https://www.statnews.com/2020/04/17/influential-covid-19-model-uses-flawed-methods-shouldnt-guide-policies-critics-say/

26. O'Neil, C. Meet the Covid Models That Are Running the World. Bloomberg News. May 14, 2020. https://finance.yahoo.com/news/meet-covid-models-running-world-210029807.html

27. Osborne, M. Inaccurate Virus Models Are Panicking Officials Into Ill-Advised Lockdowns. March 25, 2020 https://thefederalist.com/2020/03/25/inaccurate-virus-models-are-panicking-officials-into-ill-advised-lockdowns/

28. Prestigiacomo, A. Epidemiologist Behind Highly-Cited Coronavirus Model Drastically Downgrades Projection. March 26, 2020 DailyWire.com https://www.dailywire.com/news/epidemiologist-behind-highly-cited-coronavirus-model-admits-he-was-wrong-drastically-revises-model

29. World Health Organization. The-true-death-toll-of-covid-19. Estimating-global-excess-mortality. Published May 2021. Consulted July 11, 2024. https://www.who.int/data/stories/the-true-death-toll-of-covid-19-estimating-global-excess-mortality

30. The Johns Hopkins. Coronaviruses Research Center. Global tracking. consulted July 11, 2024 https://coronavirus.jhu.edu/map.html

31. Sagripanti, J-L. Seasonal Effect of Sunlight on COVID-19 among Countries with and without Lock-Downs. 2021. Open Journal of Epidemiology. Vol. 11, Issue 3, August 2021. DOI: 10.4236/ojepi.2021.113027.https://www.scirp.org/journal/paperinforcitation?paperid=111464

32. Wikipedia, the free encyclopedia. COVID-19 pandemic lockdowns. Retrieved 29 May 2020. https://en.wikipedia.org/wiki/COVID-19_pandemic_lockdowns#Countries_and_territories_without_lockdowns

33. Roser, M., Ritchie, H., Ortiz-Ospina, E., Hasell, J. Coronavirus Pandemic (COVID-19) 2020. Published Online at OurWorldInData.org. https://ourworldindata.org/COVID-hospitalizations

34. Garcia, P.J., Alarcón, A., Rojas, A.K., Saenz, R., Salgado de Snyder, N., Solimano, G., Torres, R., Tobar, S., Tuesca, R., Vargas, G., Atun, R., Bayer, A., Buss, P., Guerra, G. and Ribeiro, H. COVID-19 Response in Latin America. 2020. The American Journal of Tropical Medicine and Hygiene, 103, 1765-1772. https://doi.org/10.4269/ajtmh.20-0765

35. Block, S.S. Disinfection, Sterilization and Preservation. 5th. Edition, 2001. Lippincott Williams & Wilkins, New York.

36. Sagripanti, J.-L., Eklund, C.A., Trost, P.A., Jinneman, K.C., Abeyta, C., Kaysner, C.A., Hill, W.E. Comparative Sensitivity of Thirteen Species of Pathogenic Bacteria to Seven Chemical Germicides. 1997. American Journal of Infection Control, 25, 335-339. https://doi.org/10.1016/S0196-6553(97)90026-2

37. European Centre for Disease Prevention and Control. Infographic: Healthcare-Associated Infections—A Threat to Patient Safety in Europe. 2018. https://www.ecdc.europa.eu/en/publications-data/infographic-healthcare-associated -infections-threat-patient-safety-europe

38. Medalia. Check Market. Sample size calculator. Accessed July 2021 https://www.checkmarket.com/sample-size-calculator/

39. Sagripanti, J-L. Unexpected effect of sunlight, the environment, and public health measures in the progression of COVID-19. Conference: General Assembly. European Society of Medicine, August, 4, 2022. https://esmed.org/video-detail/?id=86

40. Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J. A Familial Cluster of Pneumonia Associated with the 2019 Novel Corona Virus Indicating Person-to-Person Transmission: A Study of a Familial Cluster. 2020. Lancet, 395, 514-523. https://pubmed.ncbi.nlm.nih.gov/31986261/https://doi.org/10.1016/S0140-6736(20)30154-9

41. Sagripanti, J-L., Aquilano, D. Reduced Social Distancing and Face Mask Wearing at Massive Soccer-Related Gatherings Did Not Affect Daily COVID-19 Infections in Argentina. Medical Research Archives. Vo.11(2). February issue 2023. https://esmed.org/MRA/mra/article/view/3471

42. Reiling, J. Dissemination of bacteria from mouth during speaking coughing and otherwise. 2000. J. Am. Med. Assoc. 284, 156

43. McNulty, M. Avon lands 33 million mask contract from US. 2014. https://www.rubbernews.com/article/20140707/NEWS/306309997/avon-lands-33-million-mask-contract-from-u-s. Accessed July 11, 2021.

44. Army protection website. Avon Protection has received an order from US Department of Defense for M50 protection mask 110 03161. 2016. https://www.armyrecognition.com/march_2016_global_defense_security_news_industry/avon_protection_has_received_an_order_from_us_department_of_defense_for_m50_protection_mask_11003161.html Accessed May 25, 2021

45. Sagripanti, J-L., Aquilano, D.R.. Progression of COVID-19 in six South American countries with different vaccination coverage. 2022. Med. Res. Arch. Vol:10, Issue 3. https://esmed.org/MRA/mra/article/view/2723/193546052

46. Sabin, A.B. Properties and behavior of orally administered attenuated poliovirus vaccine. 1957. JAMA 164,1216-1223.PMID:13438685 DOI: 10.10 01/jama.1957.62980110008008 Available Online at https://pubmed.ncbi.nlm.nih.gov/13438685/

47. Aldén, M., Olofsson, F., Yang, D., Barghouth, M., Luan, C., Rasmussen, M., De Marinis, Y. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver cell line. 2022. Curr. Issues Mol. Biol. Vol 44:1115–1126. doi: 10.3390/cimb440300 73. [PMC free article] [PubMed]