N-terminal pro B-type natriuretic peptide and insulin resistance in patients with metabolic syndrome

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Published Oct 29, 2024
DOI: https://doi.org/10.18103/mra.v12i10.5811

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Main Article Content

Ipsita Dash
Associate Professor Department of Biochemistry Saheed Rendo Majhi medical college and Hospital kalahandi, Odisha
Pratima Kumari sahu
Professor Department of Biochemistry SCB MCH Cuttack Odisha
Rasmita Kumari Padhy
Professor Department of Biochemistry Saheed rendo majhi medical college and hospital kalahandi
Om Padarabinda Dash
Assistant professor, Pulmonary medicine (Saheed rendo majhi medical college and hospital kalahandi), Odisha

Abstract

Background: B-type natriuretic peptide (BNP) and N-terminal pro-atrial natriuretic peptide (NT-proANP) plasma levels are linked to metabolic risk. Metabolic syndrome has been associated with lower levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) and insulin resistance.


Aim: This study aims to evaluate the association between NT-proBNP and insulin resistance, diabetes and cardiovascular (CV) risk factors.


Methods: A total of 183 subjects, aged 25-70 years were included in the study based on the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP-III) guidelines for metabolic syndrome. Anthropometric parameters, subclinical measurements and biochemical markers were measured. Gender-specific comparisons were conducted using unpaired t-tests. Correlation between NT-proBNP and insulin resistance in metabolic syndrome was assessed using regression analysis. A p-value of less than 0.05 was considered statistically significant.


Results: Of the 183 subjects, 58% were male and 42% were female. Key clinical parameters - such as blood pressure, body mass index (35.57±6.02 kg/m²) and waist circumference (95.50±9.75 cm) were measured. Other biochemical parameters, including elevated triglycerides, Low-Density Lipoprotein (LDL) cholesterol and blood sugar levels, as well as reduced insulin and NT-proBNP levels were observed. The study found an inverse relationship between NT-proBNP and insulin levels.


Conclusion: Females exhibited higher levels of NT-proBNP and insulin. This study identified an inverse relationship between NT-proBNP and insulin resistance.

Keywords: Metabolic Syndrome, Insulin Resistance, NT pro BNP, Dyslipidemia, cardiovascular risk

Article Details

How to Cite
DASH, Ipsita et al. N-terminal pro B-type natriuretic peptide and insulin resistance in patients with metabolic syndrome. Medical Research Archives, [S.l.], v. 12, n. 10, oct. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5811>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.18103/mra.v12i10.5811.
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Issue
Vol 12 No 10 (2024): October Issue, Issue 10, VOl.12
Section
Research Articles

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