AROMATHERAPY PROTOCOL FOR OLFACTORY RESTORATION

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31-Oct-5878.pdf
Published Oct 22, 2024
DOI: https://doi.org/10.18103/mra.v12i10.5878

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Main Article Content

Adriana Nunes Wolffenbüttel, PhD
Brazilian Academic Consortium for Integrative Health (CABSIn), Department of Natural Products Committee, Sao Paulo, Brazil.

Abstract

The loss or decrease of smell and taste can be caused by several factors, such as psychotropic medications, chronic rhinitis and sinusitis, neurological pathologies, cancer treatments, postinfectious and posttraumatic olfactory loss, older people, car accident, fire, cigarette smoke, psychological trauma, and other causes. Currently the greatest demand is due to the sequelae of Covid-19, that is the loss of smell. This aromatherapy protocol to restore the sense of smell was developed based on research data and references of the performance of essential oils (EO). EO are lipophilic substances extracted from plant species; they are mainly constituted by terpenic structures which are therapeutic bioactives. The objective of the methodology is to re-sensitize the neural route that allows the identification of aroma and taste. Following this, we recommend the use of EO to restore the health of the respiratory system, immune system, mental and emotional system. It can be observed that the olfactory and gustatory perception improve after one month this protocol is applied. There are researchers though, showing that the average time is 3 months, and it may extend above 8 months. This treatment methodology is based on neural plasticity of the olfactory system, non-invasive and safe procedure, that should thus be considered a simple addition to existing smell treatment methods.

Keywords: aromatherapy, essential oils, anosmia, hiposmia, respiratory system, olfactory training

Article Details

How to Cite
WOLFFENBÜTTEL, Adriana Nunes. AROMATHERAPY PROTOCOL FOR OLFACTORY RESTORATION. Medical Research Archives, [S.l.], v. 12, n. 10, oct. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5878>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.18103/mra.v12i10.5878.
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Issue
Vol 12 No 10 (2024): October Issue, Issue 10, VOl.12
Section
Review Articles

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References

Agarwal P, Sebghatollahi Z, Kamal M, et al. Citrus Essential Oils in Aromatherapy: Therapeutic Effects and Mechanisms. Antioxidants (Basel). 2022;11 (12):2374.

Astani A, Reichling J, Schnitzler P. Screening for antiviral activities of isolated compounds from essential oils. Evid Based Complement Alternat Med. 2011;2011:253643.

Barwich AS, Buck L. What Makes a Discovery Successful? The Story of Linda Buck and the Olfactory Receptors. Cell. 2020;181(4):749-53.

Boscolo-Rizzo P, Hopkins C, Menini A, et al. Parosmia assessment with structured questions and its functional impact in patients with long-term COVID-19-related olfactory dysfunction. Int Forum Allergy Rhinol. 2022;12(12):1570-4.

Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991;65(1):175-87.

Cooper KW, Brann DH, Farruggia MC, et al. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020;107 (2):219-33.

Dey J, Alam MT, Chandra S, et al. Neuroinvasion of SARS-CoV-2 may play a role in the breakdown of the respiratory center of the brain. J Med Virol. 2021;93(3):1296-303.

Finlay JB, Brann DH, Abi Hachem R, et al. Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium. Sci Transl Med. 2022;14(676):eadd0484.

Fodoulian L, Tuberosa J, Rossier D, et al. SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain. iScience. 2020;23(12):101839.

Gandhi P, Bafna R, Arabale G, Engineer S, Phadke S. Olfactory Device for Large Scale Pre-screening for COVID-19. Trans Indian Natl Acad Eng. 2020;5 (2):237-40.

González-Cofrade L, de Las Heras B, Apaza Ticona L, Palomino OM. Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids. Planta Med. 2019;85(17):1304-15.

Haehner A, Tosch C, Wolz M, et al. Olfactory training in patients with Parkinson's disease. PLoS One. 2013;8(4):e61680.

Hummel T, Rissom K, Reden J, Hähner A, Weidenbecher M, Hüttenbrink KB. Effects of olfactory training in patients with olfactory loss. Laryngoscope. 2009;119(3):496-9.

Kollndorfer K, Kowalczyk K, Hoche E, et al. Recovery of olfactory function induces neuroplasticity effects in patients with smell loss. Neural Plast. 2014;2014:140419.

Lee J, Cho KS, Jeon Y, et al. Characteristics and distribution of terpenes in South Korean forests. J. Ecol. Environ. 2017;41(19):1-10.

Li Q, Nakadai A, Matsushima H, et al. Phytoncides (wood essential oils) induce human natural killer cell activity. Immunopharmacol Immunotoxicol. 2006;28(2):319-33.

Malik B, Elkaddi N, Turkistani J, Spielman AI, Ozdener MH. Mammalian Taste Cells Express Functional Olfactory Receptors. Chem Senses. 2019;44(5):289-301.

Maßberg D, Hatt H. Human Olfactory Receptors: Novel Cellular Functions Outside of the Nose. Physiol Rev. 2018;98(3):1739-63.

Nadjib BM. Effective antiviral activity of essential oils and their characteristic terpenes against coronaviruses: An update. J. Pharm. Clin. Toxic. 2020;8(1):1138.

Nobel Prize in Physiology or Medicine: Richard Axel and Linda B. Buck; 2004. NobelPrize.org. Available from: https://www.nobelprize.org/prizes/medicine/2004/summary/ [Last accessed: Jul/10/2024].

Ojah EO. Review Exploring essential oils as prospective therapy against the ravaging Coronavirus (SARS-CoV-2). Iberoam J Med. 2020; 2(4):322-30.

Parma V, Ohla K, Veldhuizen MG, et al. More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis. Chem Senses. 2020;45(7):609-22.

Passos CS, Arbo MD, Rates SM, et al. Terpenoids with activity in the Central Nervous System (CNS). Rev. Bras. Farmacogn. 2009;19(1a):140-9.

Pekala K, Chandra RK, Turner JH. Efficacy of olfactory training in patients with olfactory loss: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2016;6(3):299-307.

Perry N, Perry E. Aromatherapy in the management of psychiatric disorders: clinical and neuropharmacological perspectives. CNS Drugs. 2006;20(4):257-80.

Raka RN, Wu H, Xiao J, et al. Human ectopic olfactory receptors and their food originated ligands: a review. Crit Rev Food Sci Nutr. 2022; 62(20):5424-43.

Saladin KS. Anatomy and physiology: the unity of form and function. New York: WCB McGraw-Hill; 10th ed. 2023,1234p.

Schriever VA, Lehmann S, Prange J, Hummel T. Preventing olfactory deterioration: olfactory training may be of help in older people. J Am Geriatr Soc. 2014;62(2):384-6.

Sorokowska A, Drechsler E, Karwowski M, Hummel T. Effects of olfactory training: a meta-analysis. Rhinology. 2017;55(1):17-26.

Tisserand R & Young R. Essential Oil Safety: A Guide for Health Care Professionals. Elsevier Health Sciences/Churchill Livingstone, 2nd ed. 2013,784p.

Wolffenbüttel AN, Zamboni A, Becker G, et al. Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation. Phytother Res. 2018;32(1):160-9.

Wolffenbüttel AN. Basis of Essential Oil Chemistry and Aromatherapy [Base da Química dos Óleos Essenciais e Aromaterapia]. Laszlo Ed. Brazil, 3rd ed. 2020, 462p.

Wolffenbüttel AN, Fogaça L, Malva V, et al. Evidence Map of the Clinical Effectiveness of Aromatherapy [Mapa de evidencias da efetividade clinica da aromaterapia]. BIREME/CABSIn/ PAHO/WHO: Sao Paulo; 2021. Available from: https://public.tableau.com/app/profile/bireme/viz/aromaterapia-en/evidence-map [Last accessed: July 10, 2024].

Wolffenbüttel AN. Review of Best Practice Guidelines on Aromatherapy for Olfactory Restoration: COVID-19 and Others. Integr. Med. Res. 2023;2(1):97-119.

Wolffenbüttel AN, Santos MK, Zamboni A, et al. The psychopharmacological outcomes of Citrus sinensis and Citrus aurantium essential oils after human inhalation. Phytother Res. 2024 (in the process of publishing).