Evaluation of Salt Taste Perception Threshold as an Additional Screening Tool across a Spectrum of Blood Pressure levels

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Published Nov 29, 2024
DOI: https://doi.org/10.18103/mra.v12i11.5941

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Main Article Content

Ms. Hiranya S. Deore
MBBS Final Year Student, All India Institute of Medical Sciences, Bibinagar.
Dr. Vidya Ganji
Associate Professor, Physiology, All India Institute of Medical Sciences, Bibinagar.
Dr. Madhuri Taranikanti
Additional Professor, Physiology, All India Institute of Medical Sciences, Bibinagar.
Dr. Nitin Ashok John
Professor, Physiology, All India Institute of Medical Sciences, Bibinagar.
Dr. Kalpana M
Additional Professor, Physiology, All India Institute of Medical Sciences, Bibinagar.
Dr. Madhusudhan U
Associate Professor, Physiology, All India Institute of Medical Sciences, Bibinagar.
Dr. Archana Gaur
Associate Professor, Physiology, All India Institute of Medical Sciences, Bibinagar.

Abstract

Introduction: Hypertension is one of the commonest multi-factorial conditions with largest contribution to cardiovascular diseases. The development of hypertension is secondary to complex interaction between environmental factors like high dietary salt intake, obesity and genes. Salt perception threshold (SPT) is the lowest concentration at which an individual perceives the salt taste. Recent evidence suggested that Salt Perception Threshold is related to total sodium intake and higher blood pressures. Thus, we evaluated the SPT and its relationship with dietary salt intake across a spectrum of blood pressure levels as an additional screening tool.


Objectives: To evaluate the salt taste perception threshold in normotensives, individuals with elevated blood pressure and hypertension.


Methodology: 400 adults in age group of 18-50 yrs were included in the study. Dietary intake was assessed using food frequency questionnaire (FFQ). The blood pressure was measured in sitting position and individuals were divided into: group I(controls) (SBP <120 mmHg, DBP <70 mm Hg); group II(subjects with elevated blood pressure)(SBP120-139mmHg,DBP 70-89mmHg); group III (hypertensives)(SBP ³ 140 mm Hg , DBP ³ 90mmHg). SPT was determined by salt impregnated taste strips in 5 increasing concentrations applied in mouth.


Results: Mean Salt intake was significantly high in individuals with elevated blood pressure and hypertension compared to normotensives (p<0.05). The SPT was found to be normal in 77% of normotensives and high in rest of 23%.The SPT was high in 64% of the pre-hypertensives and normal in remaining 36%. The SPT was found to be higher in 71% of the hypertensives and normal in rest of 29%.There was a positive correlation between systolic blood pressure and salt intake(r= 0. 4177).


Conclusion: The Salt Perception Threshold was found to be significantly high in individuals with elevated blood pressure and higher in hypertensive subjects leading to increased intake of salt suggesting that an association existed between salt intake, salt taste perception and BP levels.

Keywords: Salt Perception Threshold(SPT), hypertension(HTN), elevated blood pressure, salt intake, blood pressure(BP)

Article Details

How to Cite
DEORE, Ms. Hiranya S. et al. Evaluation of Salt Taste Perception Threshold as an Additional Screening Tool across a Spectrum of Blood Pressure levels. Medical Research Archives, [S.l.], v. 12, n. 11, nov. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5941>. Date accessed: 12 dec. 2024. doi: https://doi.org/10.18103/mra.v12i11.5941.
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Issue
Vol 12 No 11 (2024): November Issue, Issue 11, VOl.12
Section
Research Articles

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References

1. Indian council of medical research, public health foundation of India and Indian institute for health metrics and evaluation. India: Health of the nation’s states- The India state-level disease and burden initiative. New Delhi, India. https://phfi.org/the-work/research/the-india-state-level-disease-burden-initiative/(2017).

2. Karmali KN, Ning H, Goff DC, Lloyd-jones DM. Identifying individuals at risk for cardiovascular events across the spectrum of blood pressure levels. J Am Heart Assoc 2015;4e002126.

3. Ostchega Y, Yoon SS, Hughes J, Louis T et al. hypertension awareness, treatment, and control -continued disparities in adults: United states,2005-2006. NCHS Data brief.2008;3: 1-8.

4. World health organization. Guideline: sodium intake for adults and children. World health organization; Geneva, Switzerland: 2012.

5. Johnson C. Santos JA, Sparks E, Raj TS et al. Sources of dietary salt in North and south India estimated from 24 hour dietary recall. Nutrients. 2019;11(2):318.

6. Gleiberman L. Blood pressure and dietary salt in human populations. Ecol Food Nutr.1973; 2(2): 143-156.

7. He FJ, Nirmala DM, Mc Gregor GA. Modest salt reduction lowers blood pressure in isolated systolic hypertension and combined hypertension: A meta-analysis of randomized trials. Implications for public health. Hypertension.2005; 44: 66-70.

8. Zhang H, Thijs L, Kuznetsova T, Fagard RH, Li X et al. Progression to hypertension in the non-hypertensive participants in the Flemish study on environment, genes and health outcomes. J Hypertens.2006;24(9):1719-27.

9. John William McEvoy, Cian P Mc Carthy, Rosa Maria Bruno, Sofie Brouwers et al. ESC Scientific document group,2024 ESC Guidelines for the management of elevated blood pressure and hypertension: developed by task force on the management of elevated blood pressure and hypertension of the European society of cardiology (ESC) and endorsed by the European society of endocrinology and European society stroke organisation(ESO), European heart journal,2024; 45(38):3912-4018.

10. World health organization. Salt reduction. https://www.who.int/news-room/fact-sheets/detail/salt-reduction.

11. Strazzullo P, D’Elia L, Kandala NB, Cappuccio FP. Salt intake, stroke and cardiovascular disease: meta-analysis of prospective studies. BMJ.2009; 339:b4567.

12. He FJ, Li J, Macgregor GA. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials.BMJ.2013;346:f1325.

13. Hayes JE, Sullivian BS, Duffy VB. Explaining variability in sodium intake through oral sensory phenotype, salt sensation and liking. Physiol Behav.2010; 100(4): 369-380.

14. Geleijnse JM, Kok FJ, Grobbee DE. Blood pressure response to changes in sodium and potassium intake: A meta regression analysis of randomized trials. J Human Hypertens. 2003; 17(7):471-480.

15. Michikawa T, Nishiwaki Y, Okamura T, Asakura K et al. The taste of salt measured by a simple test and blood pressure in Japanese women and men. Hypertens Res. 2009 May; 32(5):399-403. doi: 10.1038/hr.2009.31. E pub 2009 Apr 3. PMID: 19343036.

16. Stergiou GS, Alpert B, Mieke S, Asmar R et al. A universal standard for validation of blood pressure measuring devices: Association for the advancement of medical instrumentation /European Society of Hypertension /International organisation for Standardisation (AAMI/ESH/ISO) collaboration statement. J Hypertens.2018;36(3): 71:472-478.

17. Reckelhoff JF. Mechanisms of sex and gender differences in hypertension. J Hum Hypertens 2023; 37(8); 596-601.

18. Islam JY, Zaman MM, Ahmed JU, Chaudhury SR et al. Sex differences in prevalence and determinants of hypertension among adults: A cross-sectional survey of one rural village in Bangladesh. BMJ open.2020; 10(9) e 037546.

19. Ji H, Kim A, Ebinger JE, Niiranen TJ et al. Sex differences in blood pressure trajectories over the life course. JAMA cardiol.2020;5(3): 19-26.

20. Sandberg K, Ji H. Sex differences in primary hypertension. Biol Sex Differ. 2012;3(1):7.

21. Everett B, Zajacova A. Gender differences in hypertension and hypertension awareness among young adults. Biodemography Soc Biol.2015; 61(1): 1-17.

22. Larsen SC, Angquist L, Sorensen TI, Heitmann BL. 24 hr urinary sodium excretion and subsequent change in weight, waist circumference and body composition. PLos One. 2013;8(7):e69689.

23. Ma Y, He FJ, MacGregor GA. High salt intake: independent risk factor for obesity? Hypertension. 2015;66(4):843-9.

24. Antonello VS, Antonello IC, Santos CA. Salt taste threshold, 24 hr natriuresis and blood pressure variation in normotensive individuals. Rev Assoc Med Bras.2007;53 (2):142-6.

25. Martinelli J, Conde SR, Araujo AR, Marcadenti A. Association between salt taste sensitivity threshold and blood pressure in healthy individuals : A cross sectional study. Sao Paulo Med J.2020; 138(1):4-10.

26. Nikam LH. Salt taste threshold and its relation to blood pressure in normotensive offspring of hypertensive parents amongst Indian adolescents. Indian J Physiol Pharmacol.2015;59(1):34-40.

27. Pilic L, Mavrommatis Y. Genetic predisposition to salt-sensitive normotension and its effects on salt taste perception and intake. Br J Nutr.2018; 120(7):721-731.

28. Kim CY, Ye MK, Lee YS. The salt taste threshold in untreated hypertensive patients. Clin Hypertens.2017; 23: 22.

29. Kudo A, Kitamura A et al. Salt taste perception and blood pressures levels in population based samples: the circulatory risk in community study (CIRCS).Br J Nutr.2021. 125(2):203-211.

30. Schechter PJ, Horwitz D, Henkin RI. Salt preference in patients with untreated and treated essential hypertension. Am J Med Sci. 1974; 267 (6):320-6.

31. Grillo A, Salvi L, Coruzzi P, Salvi P, Parati G. Sodium intake and hypertension. Nutrients. 2019;11(9):1970.

32. Intersalt: An international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt cooperative research group. BMJ.1988; 297(6644): 319-28.

33. Chung J, Lee S. Relationship between taste perception for salt and blood pressure in normotensives and hypertensive Korean adults: Curr Dev Nutr: 2019:3(1); 12-27.

34. Huang L, Trieu K, Yoshimura S, M Woodward, N Campbell, D Lackland et al. Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials.BMJ 2020;368:M315.

35. Graudal NA, Hubeck-Graudal T, Jurgens G, Taylor RS. Dose response relation between dietary sodium and blood pressure: a meta-regression analysis of 133 randomised controlled trials. Am J Clin Nutr 2019;109(5):1273-1278.