Sleep is a Major Participant of Epileptogenesis in Physiological Brain Networks

We aimed to provide a comprehensive review of the system epilepsy concept and adapt its principles to major epilepsy syndromes. We present our views on epileptogenesis: NREM sleep and especially sleep homeostatic plasticity are essential contributors of the epileptic transformation, upgrading and derailing normal brain networks. We follow the common process and specific features epileptic transformation in major epilepsies.