Fibromyalgia: Another Aetiological Approach
Main Article Content
Abstract
Fibromyalgia and diffuse pain disorders have been the subject of thousands of specialised publications and more than 56,000,000 references suggested by public search engines.
Nevertheless, the aetiology of diffuse pain syndrome remains poorly understood, though it accounts for nearly 20% of rheumatology consultations. Treatment is not very systematised and the results of treatment procedures remain of limited efficacy in terms of work capacity. The socio-economic consequences for patients with fibromyalgia are on the same level as those seen in patients diagnosed with rheumatoid arthritis. It would appear desirable to review the aetiological approach to be able to treat diffuse pain disorders more effectively. The association between violence experienced during childhood and the onset of fibromyalgia has been previously suggested without being considered a necessary and sufficient cause. However, thanks to the development of medical brain imaging techniques and the knowledge of epigenetic mechanisms, it seems that a previous history of sexual abuse and physical violence experienced during childhood could effectively be one of/or the cause of the onset of fibromyalgia.
Article Details
How to Cite
MARC, Golstein.
Fibromyalgia: Another Aetiological Approach.
Medical Research Archives, [S.l.], v. 12, n. 12, dec. 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6093>. Date accessed: 06 jan. 2025.
doi: https://doi.org/10.18103/mra.v12i12.6093.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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2. Kelly M. The nature of fibrositis. Ann Rheum Dis., 1945, 5(1): 1-7.
3. Kelly M. The nature of fibrositis: III. Multiple Lesions and the Neural Hypothesis. Ann Rheum Dis., 1946, 5(5): 161-167.
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5. Lesley M. Arnold, Robert M. Bennett, Leslie J. Crofford, Linda E. Dean, Daniel J. Clauw, Don L. Goldenberg, Mary-Ann Fitzcharles, Eduardo S. Paiva, Roland Staud, Piercarlo Sarzi-Puttini, Dan Buskila, and Gary J. Macfarlane, AAPT Diagnostic Criteria for Fibromyalgia, The Journal of Pain, Vol 20, No 6 (June), 2019: pp 611−628
6. Malleson P.N., al-Matar M., Pettry R.E. Idiopathic musculoskeletal pain syndromes in children. J Rheumatol.,1992,19(11):1786 1789.
7. Hudson J.I., Pope H.G. Does childhood sexual abuse cause fibromyalgia? Arthritis Rheum., 1995, 38(2): 161-163.
8. Clauw DJ , Reply to Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia, Nature Reviews Rheumatology, vol 19, May 2023, 322-323
9. Pinto AM, Geenen R, Wager TD, Lumley MA, Häuser W, Kosek E, Ablin JN, Amris K, Branco J, Buskila D, Castelhano J, Castelo-Branco M, Crofford LJ, Fitzcharles MA, López-Solà M, Luís M, Marques TR, Mease PJ, Palavra F, Rhudy JL, Uddin LQ, Castilho P, Jacobs JWG, da Silva JAP Emotion regulation and salience network: a hypothetical integrative model of fibromyalgia, Nature Reviews. Rheumatology,2023, Jan;19(1):44-60
10. Boisset-Pioro M.H., Esdaile J.M., Fitzcharles M.A. Sexual and physical abuse in women with fibromyalgia syndrome. Arthritis Rheum., 1995, 38(2): 235-241.
11. Gota C.E., Kaouk S., Wilke W.S., Fibromyalgia and Obesity: The Association Between Body Mass Index and Disability, Depression, History of Abuse, Medications, and Comorbidities. J. Clin. Rheumatol., 2015, 21(6): 289-295.
12. Nielsen M.W., Alegria S., Börjeson L., Etzkowitz H., Falk-Krzesinski H.J., Joshi A., Leahey E., Smith-Doerr L., Woolley A.W., Schiebinger L. Opinion: Gender diversity leads to better science. Proc. Natl. Acad. Sci. USA., 2017, 114(8): 1740-1742.
13. Buitendijk S., Corda D., Flodström A., Holdcroft A., Hunter, J., Pollitzer E., Rees T., Rice C., Schiebinger L., Schraudner M., Sjørup K., Tarrach R. Women in science and medicine, Lancet, 2011, 377(9768): 811.
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15. Hauser W., Hoffmann E.M.., Wolfe F., Worthing A.B., Stahl N., Rothenberg R., Walitt B., Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in fibromyalgia syndrome: a comparison of US and German outpatients. Clin. Exp. Rheumatol., 2015, 33(1 Suppl 88): S86-92.
16. Wolfe F., Anderson J., Harkness D., Bennett R.M., Caro X.J., Goldenberg D.L., Russell I.J., Yunus M.B. Work and disability status of persons with fibromyalgia. J. Rheumatol., 1997, 24(6): 1171-1178
17. Arfuch V, Aguilar Martin C, Berenguera A, Caballol Angelats R, Queiroga Gonçalves A, Carrasco-Quero N, Gonzalvez Serra G, Sancho Sol M, Fuste Anguera I, Friberg E , Petterson E, Casajuana M ; cost-utility of a multicomponent intervention for fibromyalgia versus usual care: a pragmatic randomised controlled trial; J Rehabil Med 2023;55:jm12361
18. Annemans L., Wessely S., Spaepen E., Caekelbergh K., Caubère J.P., Le lay K., Taïeb C., Health economic consequences related to the diagnosis of fibromyalgia syndrome. Arthritis Rheum. 2008, 59(12): 895-902.
19. Reisine S., Fifield J., Walsh S., Dauser Forrest D., Employment and health status changes among women with fibromyalgia: a five-year study. Arthritis Rheum. 2008, 59(12): 1735-1741.
20. Oliva-Moreno J and Vilaplana-Prieto C; social costs associated with fibromyalgia in Spain; Health Economics review (2024) 14/51; doi.org/10.1186/s13561-024-00527-1
21. Arfuch V, Aguilar Martin C, Berenguera A, Caballol Angelats R, Carrasco-Quero N, Gonzalvez Serra G, Sancho Sol M, Fuste Anguera I, Fernandez Saez J, Queiroga Gonçalves A, Casajuana M ; cost-utility analysis of a multicomponent intervention for fibromyalgia in primary care versus usual clinical practice: study protocol for an economic evaluation of a randomised control trial; BMJ open 2021;11:e043562. Doi:10.1136:bmjopen-2020-043562
22. Bombardier C.H., Buchwald D., Chronic fatigue, chronic fatigue syndrome, and fibromyalgia. Disability and health-care use. Med. Care, 1996, 34(9): 924-930.
23. Zhang L, Lopes S, Lavelle T, Ogata JonesK, Chen L , Jindal M , Zinzow H, Shi L ; economic evaluation of mindfulness-based interventions: a systematic review; mindfulness(2022)13:2359-2378
24. Palstam A., Mannerkorpi K., Workability in fibromyalgia: an update in the 21st century. Curr. Rheumatol. Rev., 2017, 13(3): 180-187.
25. Kleinstäuber M, Scgröder A , Daehler S , Pallesen K, Rask Ch , Sanyer M , Van den Bergh O, Petersen M, Rosmalen J ; aetiological understanding of fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome and classificatory analogues: a systematic review; clinical psychology in Europe 2023, vol.5(3)article e11179.
26. Gardoki-Souto I, Redolar-Ripoll D, Fontana M, Hogg B, Castro M, Blanch J, Ojeda F, Solanes A, Radua J, Valente-Gomez A, Cirici R, Perez V, Amann B, Moreno-Alcazar; prevalence and characterization of psychological trauma in patients with fibromyalgia: a cross-sectional study; Pain Research and Management vol 2022, Article ID 2114451, 16 pages
27. Hauser W., Kosseva M., Üceyler N., Klose P., Sommer C., Emotional, physical, and sexual abuse in fibromyalgia syndrome: a systematic review with meta-analysis. Arthrisis Care Res., 2011, 63(6): 808-820.
28. Saavedra-Rodriguez L., Feig L.A., Chronic social instability induces anxiety and defective social interactions across generations, Biol. Psychiatry, 2013, 73(1): 44-53.
29. Golstein MA, Steinfeld SD, Non-genetic familial transmission of fibromyalgia: role of sexual abuse? Clin Exp Rheumatol.2022 jun, 40(6):1221-1222
30. Wolff G.L., Kodell R.L., Moore S.R., Cooney C.A., Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J., 1998, 12(11): 949-957.
31. Kaati G., Bygren L.O., Edvinsson S., Cardiovascular and diabetes mortality determined by nutrition during parents’ and grandparents’ slow growth period. Eur. J. Hum. Genet., 2002, 10(11): 682 – 688.
32. Reddy M.A., Natarajan R., Recent developments in epigenetics of acute and chronic kidney diseases. Kidney Int., 2015, 88(2): 250-261.
33. van der Harst, P., de Windt L.J., Chambers J.C., Translational Perspective on Epigenetics in Cardiovascular Disease. J. Am. Coll. Cardiol., 2017, 70(5): 590-606.
34. Ovrom E, Mostert K, Khakhkhar S, McKee D, Yang P, Her Y; a comprehensive review of genetic and epigenetic contributions to the development of fibromyalgia; biomedicines 2023,11,1119
35. Low L.A., Schweinhardt P., Early life adversity as a risk factor for fibromyalgia in later life. Pain Res.Treat., 2012, 140832.
36. Menzies V., Lyon, D.E., Archer K.J., Zhou Q., Brumelle J., Jones, K.H., Gao G., York T.P., Jackson-Cook C., Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia. Nurs. Res. Pract., 2013, 795784.
37. Burri A., Marinova Z., Robinson M.D., Kühnel B., Waldenberger M., Wahl S., Kunze S., Gieger C., Livshits G., Williams F., Are epigenetic factors implicated in chronic widespread pain? PLoS. One, 2016, 11(11): e0165548.
38. Brite J, Miller-Archie SA, Cone J,The relationship between 9/11 exposure, systemic autoimmune disease and post-traumatic stress disorder:a mediational analysis; int.j.environ.res.public health 2022,19, 6514
39. Song H, Fang F, Tomasson G, Arnberg FK, Mataix-Cols D, Fernadez de la Cruz L,Almqvist C, association of stress-related disorders with subsequent autoimmune disease; JAMA June 19, 2018 vol 319 ,23, 2388-240
40. Bruer J.T., Tout est-il joué avant 3 ans ? Editions Odile Jacob, 2002.
41. Cassiers L.L.M., Sabbe B.G.C., Schmaal L., Veltman D.J., Penninx B.W.J.H., Van Den Eede F., Structural and functional brain abnormalities associated with exposure to different childhood trauma subtypes: a systematic review of neuroimaging findings. Front. Psychiatry, 2018, 9: 329.
42. Whittle S, Simmons J, Hendriksma S , Vijayakumar N , Byrne M , Dennison M , Allen N ; Childhood maltreatment , psycholopathology and the development of hippocampal subregions during adolescence ; BrainBehav 2017 ; 7 : e00607
43. Lim L., Hart H., Mehta M., Worker A., Simmons A., Mirza K., Rubia K., Grey matter volume and thickness abnormalities in young people with a history of childhood abuse. Psychol Med., 2018, 48(6):1034-1046.
44. Luo Q, Chen J, Li Y, Wu Z, Lin W, Yao J, Yu H, Wu H, Peng H; aberrant static and dynamic functional connectivity of amygdala subregions in patients with major depressive disorder and childhood maltreatment; Neuroimage: Clinical 36(2022) 103270
45. Kim S, An S, Han J , Kang Y, Bae E, Tae W-S, Ham B-J, Han K-M; childhood abuse and cortical gray matter volume in patients with major depressive disorder; Psychiatry Res 2023 Jan:319:114990 doi/ 10.1016/j
46. Harb F, Liuzzi M, Huggins A, Webb E, Fitzgerald J, Kurkowski J, deRoon-Cassini T, Larson Ch ; childhood maltreatment and amygdala-mediate Anxiety and post-traumatic stress following adult trauma; Biological Psychiatry: Global Open Science July 2024;4.
47. Beyer Eg M , Graesholt-Knudsen T, Bang Madsen K, Obel C ,Vesterby Charles A , Ingemann-Hansen O ; Distinct age-related differences among victimes in cases of suspected child-abuse , J Forensic Sci 2024;69:259-263
2. Kelly M. The nature of fibrositis. Ann Rheum Dis., 1945, 5(1): 1-7.
3. Kelly M. The nature of fibrositis: III. Multiple Lesions and the Neural Hypothesis. Ann Rheum Dis., 1946, 5(5): 161-167.
4. Wolf F, Clauw DJ, Fitzcharles M.A et al, The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity, Arthritis Care Research, Vol.62, N° 5, May 2010, pp 600-610
5. Lesley M. Arnold, Robert M. Bennett, Leslie J. Crofford, Linda E. Dean, Daniel J. Clauw, Don L. Goldenberg, Mary-Ann Fitzcharles, Eduardo S. Paiva, Roland Staud, Piercarlo Sarzi-Puttini, Dan Buskila, and Gary J. Macfarlane, AAPT Diagnostic Criteria for Fibromyalgia, The Journal of Pain, Vol 20, No 6 (June), 2019: pp 611−628
6. Malleson P.N., al-Matar M., Pettry R.E. Idiopathic musculoskeletal pain syndromes in children. J Rheumatol.,1992,19(11):1786 1789.
7. Hudson J.I., Pope H.G. Does childhood sexual abuse cause fibromyalgia? Arthritis Rheum., 1995, 38(2): 161-163.
8. Clauw DJ , Reply to Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia, Nature Reviews Rheumatology, vol 19, May 2023, 322-323
9. Pinto AM, Geenen R, Wager TD, Lumley MA, Häuser W, Kosek E, Ablin JN, Amris K, Branco J, Buskila D, Castelhano J, Castelo-Branco M, Crofford LJ, Fitzcharles MA, López-Solà M, Luís M, Marques TR, Mease PJ, Palavra F, Rhudy JL, Uddin LQ, Castilho P, Jacobs JWG, da Silva JAP Emotion regulation and salience network: a hypothetical integrative model of fibromyalgia, Nature Reviews. Rheumatology,2023, Jan;19(1):44-60
10. Boisset-Pioro M.H., Esdaile J.M., Fitzcharles M.A. Sexual and physical abuse in women with fibromyalgia syndrome. Arthritis Rheum., 1995, 38(2): 235-241.
11. Gota C.E., Kaouk S., Wilke W.S., Fibromyalgia and Obesity: The Association Between Body Mass Index and Disability, Depression, History of Abuse, Medications, and Comorbidities. J. Clin. Rheumatol., 2015, 21(6): 289-295.
12. Nielsen M.W., Alegria S., Börjeson L., Etzkowitz H., Falk-Krzesinski H.J., Joshi A., Leahey E., Smith-Doerr L., Woolley A.W., Schiebinger L. Opinion: Gender diversity leads to better science. Proc. Natl. Acad. Sci. USA., 2017, 114(8): 1740-1742.
13. Buitendijk S., Corda D., Flodström A., Holdcroft A., Hunter, J., Pollitzer E., Rees T., Rice C., Schiebinger L., Schraudner M., Sjørup K., Tarrach R. Women in science and medicine, Lancet, 2011, 377(9768): 811.
14. Schiebinger L., Women's health and clinical trials, J. Clin. Invest., 2003, 112(7): 973-977.
15. Hauser W., Hoffmann E.M.., Wolfe F., Worthing A.B., Stahl N., Rothenberg R., Walitt B., Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in fibromyalgia syndrome: a comparison of US and German outpatients. Clin. Exp. Rheumatol., 2015, 33(1 Suppl 88): S86-92.
16. Wolfe F., Anderson J., Harkness D., Bennett R.M., Caro X.J., Goldenberg D.L., Russell I.J., Yunus M.B. Work and disability status of persons with fibromyalgia. J. Rheumatol., 1997, 24(6): 1171-1178
17. Arfuch V, Aguilar Martin C, Berenguera A, Caballol Angelats R, Queiroga Gonçalves A, Carrasco-Quero N, Gonzalvez Serra G, Sancho Sol M, Fuste Anguera I, Friberg E , Petterson E, Casajuana M ; cost-utility of a multicomponent intervention for fibromyalgia versus usual care: a pragmatic randomised controlled trial; J Rehabil Med 2023;55:jm12361
18. Annemans L., Wessely S., Spaepen E., Caekelbergh K., Caubère J.P., Le lay K., Taïeb C., Health economic consequences related to the diagnosis of fibromyalgia syndrome. Arthritis Rheum. 2008, 59(12): 895-902.
19. Reisine S., Fifield J., Walsh S., Dauser Forrest D., Employment and health status changes among women with fibromyalgia: a five-year study. Arthritis Rheum. 2008, 59(12): 1735-1741.
20. Oliva-Moreno J and Vilaplana-Prieto C; social costs associated with fibromyalgia in Spain; Health Economics review (2024) 14/51; doi.org/10.1186/s13561-024-00527-1
21. Arfuch V, Aguilar Martin C, Berenguera A, Caballol Angelats R, Carrasco-Quero N, Gonzalvez Serra G, Sancho Sol M, Fuste Anguera I, Fernandez Saez J, Queiroga Gonçalves A, Casajuana M ; cost-utility analysis of a multicomponent intervention for fibromyalgia in primary care versus usual clinical practice: study protocol for an economic evaluation of a randomised control trial; BMJ open 2021;11:e043562. Doi:10.1136:bmjopen-2020-043562
22. Bombardier C.H., Buchwald D., Chronic fatigue, chronic fatigue syndrome, and fibromyalgia. Disability and health-care use. Med. Care, 1996, 34(9): 924-930.
23. Zhang L, Lopes S, Lavelle T, Ogata JonesK, Chen L , Jindal M , Zinzow H, Shi L ; economic evaluation of mindfulness-based interventions: a systematic review; mindfulness(2022)13:2359-2378
24. Palstam A., Mannerkorpi K., Workability in fibromyalgia: an update in the 21st century. Curr. Rheumatol. Rev., 2017, 13(3): 180-187.
25. Kleinstäuber M, Scgröder A , Daehler S , Pallesen K, Rask Ch , Sanyer M , Van den Bergh O, Petersen M, Rosmalen J ; aetiological understanding of fibromyalgia, irritable bowel syndrome, chronic fatigue syndrome and classificatory analogues: a systematic review; clinical psychology in Europe 2023, vol.5(3)article e11179.
26. Gardoki-Souto I, Redolar-Ripoll D, Fontana M, Hogg B, Castro M, Blanch J, Ojeda F, Solanes A, Radua J, Valente-Gomez A, Cirici R, Perez V, Amann B, Moreno-Alcazar; prevalence and characterization of psychological trauma in patients with fibromyalgia: a cross-sectional study; Pain Research and Management vol 2022, Article ID 2114451, 16 pages
27. Hauser W., Kosseva M., Üceyler N., Klose P., Sommer C., Emotional, physical, and sexual abuse in fibromyalgia syndrome: a systematic review with meta-analysis. Arthrisis Care Res., 2011, 63(6): 808-820.
28. Saavedra-Rodriguez L., Feig L.A., Chronic social instability induces anxiety and defective social interactions across generations, Biol. Psychiatry, 2013, 73(1): 44-53.
29. Golstein MA, Steinfeld SD, Non-genetic familial transmission of fibromyalgia: role of sexual abuse? Clin Exp Rheumatol.2022 jun, 40(6):1221-1222
30. Wolff G.L., Kodell R.L., Moore S.R., Cooney C.A., Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J., 1998, 12(11): 949-957.
31. Kaati G., Bygren L.O., Edvinsson S., Cardiovascular and diabetes mortality determined by nutrition during parents’ and grandparents’ slow growth period. Eur. J. Hum. Genet., 2002, 10(11): 682 – 688.
32. Reddy M.A., Natarajan R., Recent developments in epigenetics of acute and chronic kidney diseases. Kidney Int., 2015, 88(2): 250-261.
33. van der Harst, P., de Windt L.J., Chambers J.C., Translational Perspective on Epigenetics in Cardiovascular Disease. J. Am. Coll. Cardiol., 2017, 70(5): 590-606.
34. Ovrom E, Mostert K, Khakhkhar S, McKee D, Yang P, Her Y; a comprehensive review of genetic and epigenetic contributions to the development of fibromyalgia; biomedicines 2023,11,1119
35. Low L.A., Schweinhardt P., Early life adversity as a risk factor for fibromyalgia in later life. Pain Res.Treat., 2012, 140832.
36. Menzies V., Lyon, D.E., Archer K.J., Zhou Q., Brumelle J., Jones, K.H., Gao G., York T.P., Jackson-Cook C., Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia. Nurs. Res. Pract., 2013, 795784.
37. Burri A., Marinova Z., Robinson M.D., Kühnel B., Waldenberger M., Wahl S., Kunze S., Gieger C., Livshits G., Williams F., Are epigenetic factors implicated in chronic widespread pain? PLoS. One, 2016, 11(11): e0165548.
38. Brite J, Miller-Archie SA, Cone J,The relationship between 9/11 exposure, systemic autoimmune disease and post-traumatic stress disorder:a mediational analysis; int.j.environ.res.public health 2022,19, 6514
39. Song H, Fang F, Tomasson G, Arnberg FK, Mataix-Cols D, Fernadez de la Cruz L,Almqvist C, association of stress-related disorders with subsequent autoimmune disease; JAMA June 19, 2018 vol 319 ,23, 2388-240
40. Bruer J.T., Tout est-il joué avant 3 ans ? Editions Odile Jacob, 2002.
41. Cassiers L.L.M., Sabbe B.G.C., Schmaal L., Veltman D.J., Penninx B.W.J.H., Van Den Eede F., Structural and functional brain abnormalities associated with exposure to different childhood trauma subtypes: a systematic review of neuroimaging findings. Front. Psychiatry, 2018, 9: 329.
42. Whittle S, Simmons J, Hendriksma S , Vijayakumar N , Byrne M , Dennison M , Allen N ; Childhood maltreatment , psycholopathology and the development of hippocampal subregions during adolescence ; BrainBehav 2017 ; 7 : e00607
43. Lim L., Hart H., Mehta M., Worker A., Simmons A., Mirza K., Rubia K., Grey matter volume and thickness abnormalities in young people with a history of childhood abuse. Psychol Med., 2018, 48(6):1034-1046.
44. Luo Q, Chen J, Li Y, Wu Z, Lin W, Yao J, Yu H, Wu H, Peng H; aberrant static and dynamic functional connectivity of amygdala subregions in patients with major depressive disorder and childhood maltreatment; Neuroimage: Clinical 36(2022) 103270
45. Kim S, An S, Han J , Kang Y, Bae E, Tae W-S, Ham B-J, Han K-M; childhood abuse and cortical gray matter volume in patients with major depressive disorder; Psychiatry Res 2023 Jan:319:114990 doi/ 10.1016/j
46. Harb F, Liuzzi M, Huggins A, Webb E, Fitzgerald J, Kurkowski J, deRoon-Cassini T, Larson Ch ; childhood maltreatment and amygdala-mediate Anxiety and post-traumatic stress following adult trauma; Biological Psychiatry: Global Open Science July 2024;4.
47. Beyer Eg M , Graesholt-Knudsen T, Bang Madsen K, Obel C ,Vesterby Charles A , Ingemann-Hansen O ; Distinct age-related differences among victimes in cases of suspected child-abuse , J Forensic Sci 2024;69:259-263