Abstract
Atopic dermatitis is a complex chronic inflammatory skin disorder with a rising global prevalence, affecting 2.6% of the population worldwide. Its multifactorial nature, influenced by genetic, environmental, and immunological factors, challenges effective treatment and management. This article highlights key knowledge gaps in atopic dermatitis treatment, including genetic predispositions, diagnostic dilemmas, pruritus management, and psychosocial impacts. It emphasizes the need for a personalized approach to atopic dermatitis care, leveraging advancements in genetic research, metabolomics, and biomarkers to enhance drug discovery and improve disease outcomes. Despite various therapeutic options, there remains an unmet need for treatments that effectively address atopic dermatitis’ physical, psychological, and socioeconomic burdens. The role of psychosocial factors, treatment adherence, and the economic impact of atopic dermatitis are also explored. Current therapeutic approaches remain inadequate, underscoring the need for continued research into novel targeted therapies and improved patient care strategies.