Histamine: Bridging Food and Atopic Dermatitis
Main Article Content
Abstract
Atopic dermatitis is a most common chronic inflammatory skin diseases, and it is often characterized by itch, inflammation, and disruption of skin barriers. Itch associated with atopic dermatitis severely impacts the quality of life of individuals, families, and caregivers, and the incidence of itch is increasing. Here, we focused on the interplay between histamine, food, and itch mechanisms in atopic dermatitis. Histamine, a biogenic amine, plays a significant role in the pathogenesis of atopic dermatitis and related itch, and histamine levels are found elevated in atopic dermatitis individuals. A histamine-rich diet, such as ingesting foods rich in histamine and foods that trigger the cellular release of histamine, exacerbates atopic dermatitis symptoms, and the elimination of a histamine-rich diet attenuates the pathology. Further, we discussed the role of histamine receptors, specifically H1 and H4, in itch and inflammation associated with atopic dermatitis. Drugs such as antihistamines are effective in some cases, but fail to alleviate itch in atopic dermatitis, suggesting non-histaminergic itch pathways. In addition, we discussed enzymes such as diamine oxidase and histamine N-Methyltransferase, which are involved in the metabolism of histamine and, by inhibiting the activity of these enzymes leading to the accumulation of histamine, which, in turn, is responsible for atopic dermatitis and associated itch. This review provides intricate interactions between itch, diet, and histamine in atopic dermatitis and provide essential mechanistic insights and further in the development of future therapeutics.
Keywords:
Atopic dermatitis, Itch, Food, Histamine, G Protein-coupled receptors, histamine receptors, Diamine oxidase
Article Details
How to Cite
BHARTI, Arya; MISHRA, Santosh K..
Histamine: Bridging Food and Atopic Dermatitis.
Medical Research Archives, [S.l.], v. 12, n. 11, dec. 2024.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6144>. Date accessed: 12 dec. 2024.
doi: https://doi.org/10.18103/mra.v12i11.6144.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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4. Lerner EA. Is the Nervous System More Important Than the Immune System in Itch and Atopic Dermatitis? J Investig Dermatol Symp Proc. Dec 2018;19(2):S94. doi:10.1016/j.jisp.2018.10.002
5. Chung BY, Cho SI, Ahn IS, et al. Treatment of Atopic Dermatitis with a Low-histamine Diet. Ann Dermatol. Sep 2011;23 Suppl 1:S91-5. doi:10.5021/ad.2011.23.S1.S91
6. Worm M, Fiedler EM, Dolle S, et al. Exogenous histamine aggravates eczema in a subgroup of patients with atopic dermatitis. Acta Derm Venereol. 2009;89(1):52-6. doi:10.2340/00015555-0565
7. Uenishi T, Sugiura H, Tanaka T, Uehara M. Aggravation of atopic dermatitis in breast-fed infants by tree nut-related foods and fermented foods in breast milk. J Dermatol. Feb 2011;38 (2):140-5. doi:10.1111/j.1346-8138.2010.00968.x
8. Wang Z, Zhang LJ, Guha G, et al. Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice. PLoS One. 2012;7(12) :e51262. doi:10.1371/journal.pone.0051262
9. Mishra SK, Hoon MA. The cells and circuitry for itch responses in mice. Science. May 24 2013; 340(6135):968-71. doi:10.1126/science.1233765
10. Bath-Hextall F, Delamere FM, Williams HC. Dietary exclusions for established atopic eczema. Cochrane Database Syst Rev. Jan 23 2008;2008(1): CD005203. doi:10.1002/14651858.CD005203.pub2
11. Amon U, Menz U, Wolff HH. Investigations on plasma levels of mast cell mediators in acute atopic dermatitis. J Dermatol Sci. Feb 1994;7(1):63-7. doi:10.1016/0923-1811(94)90023-x
12. Nemeth K, Wilson T, Rada B, et al. Characterization and function of histamine receptors in human bone marrow stromal cells. Stem Cells. Feb 2012;30(2):222-31. doi:10.1002/stem.771
13. Parsons ME, Ganellin CR. Histamine and its receptors. Br J Pharmacol. Jan 2006;147 Suppl 1:S127-35. doi:10.1038/sj.bjp.0706440
14. Xie H, He SH. Roles of histamine and its receptors in allergic and inflammatory bowel diseases. World J Gastroenterol. May 21 2005;11 (19):2851-7. doi:10.3748/wjg.v11.i19.2851
15. Wantke F, Gotz M, Jarisch R. [The histamine-free diet]. Hautarzt. Aug 1993;44(8):512-6. Die histaminfreie Diat.
16. Kajihara Y, Murakami M, Imagawa T, Otsuguro K, Ito S, Ohta T. Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons. Neuroscience. Mar 10 2010;166(1):292-304. doi:10.1016/j.neuroscience.2009.12.001
17. Kim BM, Lee SH, Shim WS, Oh U. Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/ TRPV1 pathway in rat sensory neurons. Neurosci Lett. May 6 2004;361(1-3):159-62. doi:10.1016/j.neulet.2004.01.019
18. Behrendt H, Ring J. Histamine, antihistamines and atopic eczema. Clin Exp Allergy. Nov 1990;20 Suppl 4:25-30. doi:10.1111/j.1365-2222.1990.tb0 2473.x
19. Mohajeri S, Newman SA. Review of evidence for dietary influences on atopic dermatitis. Skin Therapy Lett. Jul-Aug 2014;19(4):5-7.
20. Rossbach K, Schaper K, Kloth C, et al. Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis. Allergy. Feb 2016;71(2):189-97.
doi:10.1111/all.12779
21. Sampson HA, Jolie PL. Increased plasma histamine concentrations after food challenges in children with atopic dermatitis. N Engl J Med. Aug 9 1984;311(6):372-6. doi:10.1056/NEJM198408093110605
22. De Benedetto A, Yoshida T, Fridy S, Park JE, Kuo IH, Beck LA. Histamine and Skin Barrier: Are Histamine Antagonists Useful for the Prevention or Treatment of Atopic Dermatitis? J Clin Med. Apr 21 2015;4(4):741-55. doi:10.3390/jcm4040741
23. Son JH, Chung BY, Kim HO, Park CW. A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria. Ann Dermatol. Apr 2018;30(2):164-172. doi:10.5021/ad.2018.30.2.164
24. Guida B, De Martino CD, De Martino SD, et al. Histamine plasma levels and elimination diet in chronic idiopathic urticaria. Eur J Clin Nutr. Feb 2000;54(2):155-8. doi:10.1038/sj.ejcn.1600911
25. Matterne U, Bohmer MM, Weisshaar E, Jupiter A, Carter B, Apfelbacher CJ. Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema. Cochrane Database Syst Rev. Jan 22 2019;1(1):CD012167.
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