The Development of SIBS and the PRESERFLO TM MicroShunt to Treat Advanced Glaucoma

Polyisobutylene-based biomaterials are elastomeric polymers specifically designed for long-term implant applications.  These polymers, which are comprised of only carbon and hydrogen atoms, contain no cleavable groups and are highly purified. Their intrinsic methyl groups interact with tissue, minimizing foreign body reactions. The present review describes the development of a glaucoma micro-shunt made from one of these polymers, poly(styrene-block-isobutylene-block-styrene) (SIBS). This review also reports recent findings in patients implanted with these PRESERFLO^TM MicroShunts.