New-Onset of Diffuse Systemic Sclerosis Following COVID-19 Vaccination: 3rd Case Described

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Alisson Barbosa da Silva Ana Tereza Amoedo Martinez Jozélio Freire de Carvalho

Abstract

Systemic sclerosis (SSc) has been reported in rare cases following COVID-19 vaccination, raising concerns about potential autoimmune triggers. Herein, we describe the third documented case of diffuse SSc post-vaccination in a 22-year-old woman with no prior autoimmune history. Symptoms, including Raynaud's phenomenon, polyarthritis, and sclerodactyly, emerged within a month after the first dose of the Pfizer-BioNTech vaccine. Laboratory and clinical evaluations confirmed the diagnosis, with no evidence of interstitial lung disease or internal organ involvement. Previous reports and the temporal association suggest a potential role of vaccination in SSc onset, emphasizing the need for further research into autoimmune risks linked to immunization.

Article Details

How to Cite
DA SILVA, Alisson Barbosa; AMOEDO MARTINEZ, Ana Tereza; DE CARVALHO, Jozélio Freire. New-Onset of Diffuse Systemic Sclerosis Following COVID-19 Vaccination: 3rd Case Described. Medical Research Archives, [S.l.], v. 13, n. 1, jan. 2025. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/6243>. Date accessed: 10 feb. 2025. doi: https://doi.org/10.18103/mra.v13i1.6243.
Section
Case Reports

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