Neuro-chikungunya: a review
Main Article Content
Abstract
Abstract – Chikungunya virus is a well-described neurological disorder. The main symptoms are fever, rash and arthralgia, and when neurological complications occur, they generally appear within 20 days of the onset of CHIKV infection. The aim of this paper is to present a review of the neurological syndromes most commonly found in chikungunya. Articles published in the electronic database MEDLINE/PubMed and Web of Science were used. It is uncertain whether neurological symptoms are due to persistence of the virus or an ineffective immune response. Neurologic syndromes, which include encephalitis, encephalopathy, myelopathy and myeloneuropathy, have been the major cause of death and disability related to CHIKV infection.
Article Details
How to Cite
MARTINS, HUGO et al.
Neuro-chikungunya: a review.
Medical Research Archives, [S.l.], v. 4, n. 5, sep. 2016.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/630>. Date accessed: 23 nov. 2024.
Keywords
Chikungunya, fever, headache, arthralgia.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart JP, et al. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis. 2007 Jun 1;44(11):1401-7. PubMed PMID: 17479933.
2. Gerardin P, Fianu A, Malvy D, Mussard C, Boussaid K, Rollot O, et al. Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort study. BMC Med. 2011;9:5. PubMed PMID: 21235760. Pubmed Central PMCID: PMC3029216.
3. Bank AM, Batra A, Colorado RA, Lyons JL. Myeloradiculopathy associated with chikungunya virus infection. J Neurovirol. 2016 Feb;22(1):125-8. PubMed PMID: 26306687.
4. Dupuis-Maguiraga L, Noret M, Brun S, Le Grand R, Gras G, Roques P. Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. PLoS Negl Trop Dis. 2012;6(3):e1446. PubMed PMID: 22479654. Pubmed Central PMCID: PMC3313943.
5. Chusri S, Siripaitoon P, Hirunpat S, Silpapojakul K. Case reports of neuro-Chikungunya in southern Thailand. Am J Trop Med Hyg. 2011 Aug;85(2):386-9. PubMed PMID: 21813863. Pubmed Central PMCID: PMC3144841.
6. Weaver SC, Winegar R, Manger ID, Forrester NL. Alphaviruses: population genetics and determinants of emergence. Antiviral Res. 2012 Jun;94(3):242-57. PubMed PMID: 22522323. Pubmed Central PMCID: PMC3737490.
7. Pialoux G, Gauzere BA, Jaureguiberry S, Strobel M. Chikungunya, an epidemic arbovirosis. Lancet Infect Dis. 2007 May;7(5):319-27. PubMed PMID: 17448935.
8. Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT. Chikungunya: a re-emerging virus. Lancet. 2012 Feb 18;379(9816):662-71. PubMed PMID: 22100854.
9. de Lima Martins HA, Bernardino SN, Ribas KH, dos Santos CC, Antunes T, Ribas VR, et al. Outbreak of Neuro-Chikungunya in Northeastern Brazil. Journal of Neuroinfectious Diseases. 2016;2016.
10. Ernould S, Walters H, Alessandri JL, Llanas B, Jaffar MC, Robin S, et al. [Chikungunya in paediatrics: epidemic of 2005-2006 in Saint-Denis, Reunion Island]. Arch Pediatr. 2008 Mar;15(3):253-62. PubMed PMID: 18321688. Aspects pediatriques de l'epidemie de Chikungunya a l'ile de la Reunion.
11. Lemant J, Boisson V, Winer A, Thibault L, Andre H, Tixier F, et al. Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006. Crit Care Med. 2008 Sep;36(9):2536-41. PubMed PMID: 18679124.
12. Sane J, Kurkela S, Vapalahti O. [Chikungunya, a new global epidemic?]. Duodecim. 2011;127(5):457-63. PubMed PMID: 21491752. Chikungunya, uusi maailmanlaajuinen epidemia?
13. Taraphdar D, Roy B, Chatterjee S. Chikungunya virus infection amongst the acute encephalitis syndrome cases in West Bengal, India. Indian journal of medical microbiology. 2015;33(5):153.
14. Tandale BV, Sathe PS, Arankalle VA, Wadia R, Kulkarni R, Shah SV, et al. Systemic involvements and fatalities during Chikungunya epidemic in India, 2006. Journal of Clinical Virology. 2009;46(2):145-9.
15. Mathew A, Goyal V, George E, Thekkemuriyil D, Jayakumar B, Chopra A. Rheumatic‐musculoskeletal pain and disorders in a naïve group of individuals 15 months following a Chikungunya viral epidemic in south India: a population based observational study. International journal of clinical practice. 2011;65(12):1306-12.
16. Laras K, Sukri NC, Larasati RP, Bangs MJ, Kosim R, Djauzi, et al. Tracking the re-emergence of epidemic chikungunya virus in Indonesia. Trans R Soc Trop Med Hyg. 2005 Feb;99(2):128-41. PubMed PMID: 15693148.
17. Haas H, Robin S, Ramful D, Houdon L, Minodier P, Gerardin P. [Chikungunya virus infections in children]. Arch Pediatr. 2009 Oct;16 Suppl 2:S72-9. PubMed PMID: 19836680. Infections a virus Chikungunya chez l'enfant.
18. van den Doel P, Volz A, Roose JM, Sewbalaksing VD, Pijlman GP, van Middelkoop I, et al. Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge. PLoS Negl Trop Dis. 2014 Sep;8(9):e3101. PubMed PMID: 25188230. Pubmed Central PMCID: PMC4154657.
19. Oliveira JR, Gerardin P, Couderc T, Randrianaivo H, Fritel X, Lecuit M. Chikungunya virus-associated encephalitis: A cohort study on La Reunion Island, 2005-2009. Neurology. 2016 May 24;86(21):2025-6. PubMed PMID: 27217467.
20. Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, et al. Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Reunion. Epidemiol Infect. 2009 Apr;137(4):534-41. PubMed PMID: 18694529.
21. Rampal, Sharda M, Meena H. Neurological complications in Chikungunya fever. J Assoc Physicians India. 2007 Nov;55:765-9. PubMed PMID: 18290551.
22. Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Saravanan S, Sathe PS. Optic neuritis associated with chikungunya virus infection in South India. Arch Ophthalmol. 2007 Oct;125(10):1381-6. PubMed PMID: 17923547.
23. Chandak NH, Kashyap RS, Kabra D, Karandikar P, Saha SS, Morey SH, et al. Neurological complications of Chikungunya virus infection. Neurol India. 2009 Mar-Apr;57(2):177-80. PubMed PMID: 19439849.
24. Maity P, Roy P, Basu A, Das B, Ghosh US. A case of ADEM following Chikungunya fever. J Assoc Physicians India. 2014 May;62(5):441-2. PubMed PMID: 25508016.
25. Mazaud R, Salaun JJ, Montabone H, Goube P, Bazillio R. [Acute neurologic and sensorial disorders in dengue and Chikungunya fever]. Bull Soc Pathol Exot Filiales. 1971 Jan-Feb;64(1):22-30. PubMed PMID: 5109175. Troubles neurologiques et sensoriels aigus dans la dengue et la fievre a Chikungunya.
26. Tournebize P, Charlin C, Lagrange M. [Neurological manifestations in Chikungunya: about 23 cases collected in Reunion Island]. Revue neurologique. 2009;165(1):48-51.
27. Casolari S, Briganti E, Zanotti M, Zauli T, Nicoletti L, Magurano F, et al. A fatal case of encephalitis associated with Chikungunya virus infection. Scand J Infect Dis. 2008;40(11-12):995-6. PubMed PMID: 18819040.
28. Lewthwaite P, Vasanthapuram R, Osborne JC, Begum A, Plank JL, Shankar MV, et al. Chikungunya virus and central nervous system infections in children, India. Emerging infectious diseases. 2009;15(2):329-31.
29. Robin S, Ramful D, Le Seach F, Jaffar-Bandjee MC, Rigou G, Alessandri JL. Neurologic manifestations of pediatric chikungunya infection. J Child Neurol. 2008 Sep;23(9):1028-35. PubMed PMID: 18287573.
30. Pellot AS, Alessandri JL, Robin S, Samperiz S, Attali T, Brayer C, et al. [Severe forms of chikungunya virus infection in a pediatric intensive care unit on Reunion Island]. Med Trop (Mars). 2012 Mar;72 Spec No:88-93. PubMed PMID: 22693937. Infections graves a virus chikungunya en reanimation pediatrique a l'ile de La Reunion.
31. Kalita J, Kumar P, Misra UK. Stimulus-sensitive myoclonus and cerebellar ataxia following chikungunya meningoencephalitis. Infection. 2013 Jun;41(3):727-9. PubMed PMID: 23355353.
32. Ganesan K, Diwan A, Shankar SK, Desai SB, Sainani GS, Katrak SM. Chikungunya encephalomyeloradiculitis: report of 2 cases with neuroimaging and 1 case with autopsy findings. AJNR Am J Neuroradiol. 2008 Oct;29(9):1636-7. PubMed PMID: 18566010.
33. Wielanek A, De Monredon J, El Amrani M, Roger J, Serveaux J. Guillain-Barré syndrome complicating a Chikungunya virus infection. Neurology. 2007;69(22):2105-7.
34. Shenoy S, Pradeep G. Neurodevelopmental outcome of neonates with vertically transmitted Chikungunya fever with encephalopathy. 2012.
35. Renault P, Solet JL, Sissoko D, Balleydier E, Larrieu S, Filleul L, et al. A major epidemic of chikungunya virus infection on Reunion Island, France, 2005-2006. Am J Trop Med Hyg. 2007 Oct;77(4):727-31. PubMed PMID: 17978079.
2. Gerardin P, Fianu A, Malvy D, Mussard C, Boussaid K, Rollot O, et al. Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort study. BMC Med. 2011;9:5. PubMed PMID: 21235760. Pubmed Central PMCID: PMC3029216.
3. Bank AM, Batra A, Colorado RA, Lyons JL. Myeloradiculopathy associated with chikungunya virus infection. J Neurovirol. 2016 Feb;22(1):125-8. PubMed PMID: 26306687.
4. Dupuis-Maguiraga L, Noret M, Brun S, Le Grand R, Gras G, Roques P. Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. PLoS Negl Trop Dis. 2012;6(3):e1446. PubMed PMID: 22479654. Pubmed Central PMCID: PMC3313943.
5. Chusri S, Siripaitoon P, Hirunpat S, Silpapojakul K. Case reports of neuro-Chikungunya in southern Thailand. Am J Trop Med Hyg. 2011 Aug;85(2):386-9. PubMed PMID: 21813863. Pubmed Central PMCID: PMC3144841.
6. Weaver SC, Winegar R, Manger ID, Forrester NL. Alphaviruses: population genetics and determinants of emergence. Antiviral Res. 2012 Jun;94(3):242-57. PubMed PMID: 22522323. Pubmed Central PMCID: PMC3737490.
7. Pialoux G, Gauzere BA, Jaureguiberry S, Strobel M. Chikungunya, an epidemic arbovirosis. Lancet Infect Dis. 2007 May;7(5):319-27. PubMed PMID: 17448935.
8. Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT. Chikungunya: a re-emerging virus. Lancet. 2012 Feb 18;379(9816):662-71. PubMed PMID: 22100854.
9. de Lima Martins HA, Bernardino SN, Ribas KH, dos Santos CC, Antunes T, Ribas VR, et al. Outbreak of Neuro-Chikungunya in Northeastern Brazil. Journal of Neuroinfectious Diseases. 2016;2016.
10. Ernould S, Walters H, Alessandri JL, Llanas B, Jaffar MC, Robin S, et al. [Chikungunya in paediatrics: epidemic of 2005-2006 in Saint-Denis, Reunion Island]. Arch Pediatr. 2008 Mar;15(3):253-62. PubMed PMID: 18321688. Aspects pediatriques de l'epidemie de Chikungunya a l'ile de la Reunion.
11. Lemant J, Boisson V, Winer A, Thibault L, Andre H, Tixier F, et al. Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006. Crit Care Med. 2008 Sep;36(9):2536-41. PubMed PMID: 18679124.
12. Sane J, Kurkela S, Vapalahti O. [Chikungunya, a new global epidemic?]. Duodecim. 2011;127(5):457-63. PubMed PMID: 21491752. Chikungunya, uusi maailmanlaajuinen epidemia?
13. Taraphdar D, Roy B, Chatterjee S. Chikungunya virus infection amongst the acute encephalitis syndrome cases in West Bengal, India. Indian journal of medical microbiology. 2015;33(5):153.
14. Tandale BV, Sathe PS, Arankalle VA, Wadia R, Kulkarni R, Shah SV, et al. Systemic involvements and fatalities during Chikungunya epidemic in India, 2006. Journal of Clinical Virology. 2009;46(2):145-9.
15. Mathew A, Goyal V, George E, Thekkemuriyil D, Jayakumar B, Chopra A. Rheumatic‐musculoskeletal pain and disorders in a naïve group of individuals 15 months following a Chikungunya viral epidemic in south India: a population based observational study. International journal of clinical practice. 2011;65(12):1306-12.
16. Laras K, Sukri NC, Larasati RP, Bangs MJ, Kosim R, Djauzi, et al. Tracking the re-emergence of epidemic chikungunya virus in Indonesia. Trans R Soc Trop Med Hyg. 2005 Feb;99(2):128-41. PubMed PMID: 15693148.
17. Haas H, Robin S, Ramful D, Houdon L, Minodier P, Gerardin P. [Chikungunya virus infections in children]. Arch Pediatr. 2009 Oct;16 Suppl 2:S72-9. PubMed PMID: 19836680. Infections a virus Chikungunya chez l'enfant.
18. van den Doel P, Volz A, Roose JM, Sewbalaksing VD, Pijlman GP, van Middelkoop I, et al. Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge. PLoS Negl Trop Dis. 2014 Sep;8(9):e3101. PubMed PMID: 25188230. Pubmed Central PMCID: PMC4154657.
19. Oliveira JR, Gerardin P, Couderc T, Randrianaivo H, Fritel X, Lecuit M. Chikungunya virus-associated encephalitis: A cohort study on La Reunion Island, 2005-2009. Neurology. 2016 May 24;86(21):2025-6. PubMed PMID: 27217467.
20. Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, et al. Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Reunion. Epidemiol Infect. 2009 Apr;137(4):534-41. PubMed PMID: 18694529.
21. Rampal, Sharda M, Meena H. Neurological complications in Chikungunya fever. J Assoc Physicians India. 2007 Nov;55:765-9. PubMed PMID: 18290551.
22. Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Saravanan S, Sathe PS. Optic neuritis associated with chikungunya virus infection in South India. Arch Ophthalmol. 2007 Oct;125(10):1381-6. PubMed PMID: 17923547.
23. Chandak NH, Kashyap RS, Kabra D, Karandikar P, Saha SS, Morey SH, et al. Neurological complications of Chikungunya virus infection. Neurol India. 2009 Mar-Apr;57(2):177-80. PubMed PMID: 19439849.
24. Maity P, Roy P, Basu A, Das B, Ghosh US. A case of ADEM following Chikungunya fever. J Assoc Physicians India. 2014 May;62(5):441-2. PubMed PMID: 25508016.
25. Mazaud R, Salaun JJ, Montabone H, Goube P, Bazillio R. [Acute neurologic and sensorial disorders in dengue and Chikungunya fever]. Bull Soc Pathol Exot Filiales. 1971 Jan-Feb;64(1):22-30. PubMed PMID: 5109175. Troubles neurologiques et sensoriels aigus dans la dengue et la fievre a Chikungunya.
26. Tournebize P, Charlin C, Lagrange M. [Neurological manifestations in Chikungunya: about 23 cases collected in Reunion Island]. Revue neurologique. 2009;165(1):48-51.
27. Casolari S, Briganti E, Zanotti M, Zauli T, Nicoletti L, Magurano F, et al. A fatal case of encephalitis associated with Chikungunya virus infection. Scand J Infect Dis. 2008;40(11-12):995-6. PubMed PMID: 18819040.
28. Lewthwaite P, Vasanthapuram R, Osborne JC, Begum A, Plank JL, Shankar MV, et al. Chikungunya virus and central nervous system infections in children, India. Emerging infectious diseases. 2009;15(2):329-31.
29. Robin S, Ramful D, Le Seach F, Jaffar-Bandjee MC, Rigou G, Alessandri JL. Neurologic manifestations of pediatric chikungunya infection. J Child Neurol. 2008 Sep;23(9):1028-35. PubMed PMID: 18287573.
30. Pellot AS, Alessandri JL, Robin S, Samperiz S, Attali T, Brayer C, et al. [Severe forms of chikungunya virus infection in a pediatric intensive care unit on Reunion Island]. Med Trop (Mars). 2012 Mar;72 Spec No:88-93. PubMed PMID: 22693937. Infections graves a virus chikungunya en reanimation pediatrique a l'ile de La Reunion.
31. Kalita J, Kumar P, Misra UK. Stimulus-sensitive myoclonus and cerebellar ataxia following chikungunya meningoencephalitis. Infection. 2013 Jun;41(3):727-9. PubMed PMID: 23355353.
32. Ganesan K, Diwan A, Shankar SK, Desai SB, Sainani GS, Katrak SM. Chikungunya encephalomyeloradiculitis: report of 2 cases with neuroimaging and 1 case with autopsy findings. AJNR Am J Neuroradiol. 2008 Oct;29(9):1636-7. PubMed PMID: 18566010.
33. Wielanek A, De Monredon J, El Amrani M, Roger J, Serveaux J. Guillain-Barré syndrome complicating a Chikungunya virus infection. Neurology. 2007;69(22):2105-7.
34. Shenoy S, Pradeep G. Neurodevelopmental outcome of neonates with vertically transmitted Chikungunya fever with encephalopathy. 2012.
35. Renault P, Solet JL, Sissoko D, Balleydier E, Larrieu S, Filleul L, et al. A major epidemic of chikungunya virus infection on Reunion Island, France, 2005-2006. Am J Trop Med Hyg. 2007 Oct;77(4):727-31. PubMed PMID: 17978079.