Abstract
B-cell lymphoma is a common hematopoietic neoplasm in dogs, characterized by aggressive behavior and a guarded prognosis. This case report describes the treatment of an elderly dog diagnosed with B-cell lymphoma, which initially failed to respond to conventional therapy. Due to the limitations posed by the patient’s poor tolerance to chemotherapy and the priority of preserving quality of life, an integrative therapeutic approach was adopted. Following four years of treatment, the patient was discharged without signs of relapse and remains alive at the remarkable age of 18. Injectable Viscum album, known for its immunomodulatory and cytotoxic properties, was employed as part of the therapeutic regimen, potentially contributing to antitumor responses and disease control. This case underscores the potential efficacy and safety of injectable Viscum album as a complementary therapy for lymphoma in dogs, offering a promising alternative for managing hematopoietic neoplasms in geriatric patients. The absence of significant adverse effects and the prolonged survival observed in this patient further support the value of integrative approaches in veterinary oncology.