Breast Cancer Profile Analysis in the Health Regions of a Southern Brazilian State from 2013 to 2021
Main Article Content
Maria Eduarda Calil Netto
http://orcid.org/0000-0002-6429-9801
Jessica da Fontoura
http://orcid.org/0009-0006-4494-0362
Lara Marcon Dandolini
Gabriele de Sousa Silva
Rebeca Neves Heinzen
http://orcid.org/0000-0002-4898-5764
http://orcid.org/0000-0002-6429-9801
Jessica da Fontoura
http://orcid.org/0009-0006-4494-0362
Lara Marcon Dandolini
Gabriele de Sousa Silva
Rebeca Neves Heinzen
http://orcid.org/0000-0002-4898-5764
Abstract
Background: The present study aimed to identify the profile of breast cancer in Santa Catarina from 2013 to 2021.
Aims: The main objective was to profile breast cancer in Santa Catarina from 2013 to 2021, focusing on prevalence by age group, analyzing temporal trends in mortality across macro-regions, and comparing mortality rates by age in different state regions.
Methods: The study utilized a mixed ecological approach in Santa Catarina, analyzing public records from the Panel Oncologia on Tabnet at the Department of Informatics of DATASUS. It focused on women over 18 years old diagnosed with breast cancer in SC from 2013 to 2021, including age at diagnosis, mortality rates, treatment options, and diagnosis by health region, totaling 73,487 cases.
Results: Health data from 16 regions in Santa Catarina showed an increase in breast cancer diagnoses, treatments, and mortality. Several areas, including Alto Vale do Rio do Peixe, saw significant rises in diagnoses and treatments, with a mortality trend among young women.
Conclusion: The analysis of breast cancer in SC shows increased diagnoses and treatments, with Alto Vale do Rio do Peixe experiencing rising mortality. There is a significant rise in diagnoses among young women, highlighting the need for targeted screening for this demographic.
Keywords:
Breast Neoplasms, Epidemiology, Risk Factors, Antineoplastic Protocols
Article Details
How to Cite
NETTO, Maria Eduarda Calil et al.
Breast Cancer Profile Analysis in the Health Regions of a Southern Brazilian State from 2013 to 2021.
Medical Research Archives, [S.l.], v. 13, n. 3, mar. 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6380>. Date accessed: 06 apr. 2025.
doi: https://doi.org/10.18103/mra.v3i3.6380.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLO-BOCAN estimates of incidence and mortality world-wide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424. doi: https://doi.org/10.3322/caac.21492
2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA: a Cancer Journal for Clinicians. 2019;69(1):7-34. doi: https://doi.org/10.3322/caac.21551
3. De Oliveira Santos M. Estimativa/2020 – Incidência de Câncer no Brasil. Revista Brasileira de Cancerolo-gia. 2020;66(1). doi: https://doi.org/10.32635/2176-9745.rbc.2020v66n1.927
4. de Oliveira NPD, de Camargo Cancela M, Martins LFL, de Souza DLB. A multilevel assessment of the so-cial determinants associated with the late stage di-agnosis of breast cancer. Scientific Reports. 2021;11(1):2712. doi: https://doi.org/10.1038/s41598-021-82047-0
5. Tomaz KP, Farias SH, Maia Neto WL, Figueiredo FW dos S, Adami F. Impact of income inequality on breast cancer mortality according to socioeconomic status in the Federative Units of Brazil. Frontiers in Public Health. 2022;10:972204. doi: https://doi.org/10.3389/fpubh.2022.972204
6. Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanislawek A. Breast cancer—epidemiology, Risk factors, classification, Prognostic markers, and Cur¬rent Treatment Strategies—an Updated Re¬view. Cancers. 2021;13(17):4287. doi: https://doi.org/10.3390/cancers13174287
7. Ruth KS, Day FR, Tyrrell J, et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine. 2020;26(2):252-258. doi: https://doi.org/10.1038/s41591-020-0751-5
8. Brandão M, Caparica R, Malorni L, Prat A, Carey LA, Piccart M. What Is the Real Impact of Estrogen Re¬ceptor Status on the Prognosis and Treatment of HER2-Positive Early Breast Cancer? Clinical Cancer Research. 2020;26(12):2783-2788. doi: https://doi.org/10.1158/1078-0432.CCR-19-2612
9. Rossi L, Mazzara C, Pagani O. Diagnosis and Treat-ment of Breast Cancer in Young Women. Current Treatment Options in Oncology. 2019;20(12). doi: https://doi.org/10.1007/s11864-019-0685-7
10. Weigelt B, Horlings H, Kreike B, et al. Refinement of breast cancer classification by molecular characteri-zation of histological special types. The Journal of Pa¬thology. 2008;216(2):141-150. doi: https://doi.org/10.1002/path.2407
11. Sinn HP, Kreipe H. A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition. Breast Care. 2013;8(2):149-154. doi:_https://doi.org/10.1159/000350774
12. Erber R, Hartmann A. Histology of Luminal Breast Cancer. Breast Care. 2020;15(4):327-336. doi:https://doi.org/10.1159/000509025
13. Allison KH, Hammond MEH, Dowsett M, et al. Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update. Archives of Pathology & Laboratory Medicine. 2020;144(5):545-563. doi: https://doi.org/10.5858/arpa.2019-0904-sa
14. Diretrizes Diagnósticas E Terapêuticas Do Carcinoma de Mama.; 2018. https://www.gov.br/conitec/pt-br/midias/con¬sul¬tas/relatori¬os/2018/rela-torio_ddt_carcionomademama_julho_2018.pdf
15. Pashayan N, Antoniou AC, Ivanus U, et al. Personal-ized early detection and prevention of breast cancer: ENVISION consensus statement. Nature Reviews Clini¬cal Oncology. 2020;17. doi: https://doi.org/10.1038/s41571-020-0388-9
16. Detecção precoce. Instituto Nacional de Câncer - INCA. https://www.gov.br/inca/pt-br/assun-tos/gestor-e-profissional-de-saude/controle-do-can-cer-de-mama/acoes/deteccao-precoce
17. Rastreamento e Propedêutica do Câncer de Mama. www.febrasgo.org.br. https://www.febrasgo.org.br/pt/compo-nent/zoo/item/rastreamento-e-propedeutica
18. Bretas G, Renna NL, Bines J. Practical considerations for expediting breast cancer treatment in Brazil. The Lancet Regional Health - Americas. 2021;2:100028. doi: https://doi.org/10.1016/j.lana.2021.100028
19. Dados Gerais - ANS - Agência Nacional de Saúde Suplementar. www.ans.gov.br. https://www.ans.gov.br/perfil-do-setor/dados-ge-rais
20. Dados e números sobre câncer de mama. Relatório anual 2022. https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/dados_e_numeros_site_cancer_mama_setembro2022.pdf
21. Rosa DD, Bines J, Werutsky G, et al. The impact of sociodemographic factors and health insurance cov-erage in the diagnosis and clinicopathological char-acteristics of breast cancer in Brazil: AMAZONA III study (GBECAM 0115). Breast Cancer Research and Treatment. 2020;183(3):749-757. doi: https://doi.org/10.1007/s10549-020-05831-y
22. Mathew A, George PS, Kunnambath R, et al. Educa-tional Status, Cancer Stage, and Survival in South In¬dia: A Population-Based Study. JCO Global Oncol¬ogy. 2020;(6):1704-1711. doi: https://doi.org/10.1200/go.20.00259
23. Fonseca B de P, Albuquerque PC, Saldanha R de F, Zicker F. Geographic accessibility to cancer treatment in Brazil: A network analysis. The Lancet Regional Health - Americas. 2022;7:100153. doi: https://doi.org/10.1016/j.lana.2021.100153
24. Santos M de O. Estimativa 2018: Incidência de Câncer no Brasil. Revista Brasileira de Cancerologia. 2018;64(1):119-120. doi: https://doi.org/10.32635/2176-9745.rbc.2018v64n1.115
25. Dados e Números sobre Câncer de Mama - Relatório Anual 2023. INCA - Instituto Nacional de Câncer. Pub¬lished September 29, 2022. https://www.inca.gov.br/publi-cacoes/relatorios/dados-e-numeros-sobre-cancer-de-mama-relatorio-anual-2023
26. Simon SD, Bines J, Werutsky G, et al. Characteristics and prognosis of stage I-III breast cancer subtypes in Brazil: The AMAZONA retrospective cohort study. The Breast. 2019;44:113-119. doi: https://doi.org/10.1016/j.breast.2019.01.008
27. Miglioretti DL, Zhu W, Kerlikowske K, et al. Breast Tu¬mor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Menopausal Status. JAMA Oncology. 2015;1(8):1069-1077. doi: https://doi.org/10.1001/jamaoncol.2015.3084
28. Ailton Augustinho Marchi, Salete M. Adesão ao rastreamento mamográfico oportunístico em serviços de saúde públicos e privados. Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(4). doi: https://doi.org/10.1590/s0100-72032010000400007
29. dos-Santos-Silva I, De Stavola BL, Renna NL, et al. Ethnoracial and social trends in breast cancer staging at diagnosis in Brazil, 2001–14: a case only analy¬sis. The Lancet Global Health. 2019;7(6):e784-e797. doi: https://doi.org/10.1016/s2214-109x(19)30151-2
30. Alves Soares Ferreira N, Melo Figueiredo de Car-valho S, Engrácia Valenti V, et al. Treatment delays among women with breast cancer in a low socio-eco¬nomic status region in Brazil. BMC Women’s Health. 2017;17(1). doi: https://doi.org/10.1186/s12905-016-0359-6
31. Tratamento. Ministério da Saúde. https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/c/cancer-de-mama/tratamento
32. TabnetBD 1.0 - Painel-Oncologia - Brasil. Data-sus.gov.br. Published 2020. http://tab¬net.data-sus.gov.br/cgi/webt-abx.exe?Painel_Onco/Painel_Oncologiabr.Def
33. Santaella T. Santa Catarina apresenta 2° maior crescimento em número absoluto da população no Censo 2022 - Agência de Notícias SECOM. Agência de Notícias SECOM. Published June 28, 2023. https://estado.sc.gov.br/noticias/santa-catarina-apresenta-segundo-maior-crescimento-em-numero-absoluto-de-populacao-no-censo-2022/
34. Fábio Aleixo. Orçamento da Saúde cresceu apenas 2,5% em 10 anos, revela pesquisa do IEPS e Umane - IEPS. Published May 8, 2023. https://ieps.org.br/orcamento-da-saude-cresceu-apenas-25-em-10-anos-revela-pesquisa-do-ieps-e-umane/
35. LEI No 12.732, DE 22 De Novembro De 2012. Planalto.gov.br. Published 2022. https://www.planalto.gov.br/ccivil_03/_ato2011-2014/2012/lei/l12732.htm
2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA: a Cancer Journal for Clinicians. 2019;69(1):7-34. doi: https://doi.org/10.3322/caac.21551
3. De Oliveira Santos M. Estimativa/2020 – Incidência de Câncer no Brasil. Revista Brasileira de Cancerolo-gia. 2020;66(1). doi: https://doi.org/10.32635/2176-9745.rbc.2020v66n1.927
4. de Oliveira NPD, de Camargo Cancela M, Martins LFL, de Souza DLB. A multilevel assessment of the so-cial determinants associated with the late stage di-agnosis of breast cancer. Scientific Reports. 2021;11(1):2712. doi: https://doi.org/10.1038/s41598-021-82047-0
5. Tomaz KP, Farias SH, Maia Neto WL, Figueiredo FW dos S, Adami F. Impact of income inequality on breast cancer mortality according to socioeconomic status in the Federative Units of Brazil. Frontiers in Public Health. 2022;10:972204. doi: https://doi.org/10.3389/fpubh.2022.972204
6. Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanislawek A. Breast cancer—epidemiology, Risk factors, classification, Prognostic markers, and Cur¬rent Treatment Strategies—an Updated Re¬view. Cancers. 2021;13(17):4287. doi: https://doi.org/10.3390/cancers13174287
7. Ruth KS, Day FR, Tyrrell J, et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine. 2020;26(2):252-258. doi: https://doi.org/10.1038/s41591-020-0751-5
8. Brandão M, Caparica R, Malorni L, Prat A, Carey LA, Piccart M. What Is the Real Impact of Estrogen Re¬ceptor Status on the Prognosis and Treatment of HER2-Positive Early Breast Cancer? Clinical Cancer Research. 2020;26(12):2783-2788. doi: https://doi.org/10.1158/1078-0432.CCR-19-2612
9. Rossi L, Mazzara C, Pagani O. Diagnosis and Treat-ment of Breast Cancer in Young Women. Current Treatment Options in Oncology. 2019;20(12). doi: https://doi.org/10.1007/s11864-019-0685-7
10. Weigelt B, Horlings H, Kreike B, et al. Refinement of breast cancer classification by molecular characteri-zation of histological special types. The Journal of Pa¬thology. 2008;216(2):141-150. doi: https://doi.org/10.1002/path.2407
11. Sinn HP, Kreipe H. A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition. Breast Care. 2013;8(2):149-154. doi:_https://doi.org/10.1159/000350774
12. Erber R, Hartmann A. Histology of Luminal Breast Cancer. Breast Care. 2020;15(4):327-336. doi:https://doi.org/10.1159/000509025
13. Allison KH, Hammond MEH, Dowsett M, et al. Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update. Archives of Pathology & Laboratory Medicine. 2020;144(5):545-563. doi: https://doi.org/10.5858/arpa.2019-0904-sa
14. Diretrizes Diagnósticas E Terapêuticas Do Carcinoma de Mama.; 2018. https://www.gov.br/conitec/pt-br/midias/con¬sul¬tas/relatori¬os/2018/rela-torio_ddt_carcionomademama_julho_2018.pdf
15. Pashayan N, Antoniou AC, Ivanus U, et al. Personal-ized early detection and prevention of breast cancer: ENVISION consensus statement. Nature Reviews Clini¬cal Oncology. 2020;17. doi: https://doi.org/10.1038/s41571-020-0388-9
16. Detecção precoce. Instituto Nacional de Câncer - INCA. https://www.gov.br/inca/pt-br/assun-tos/gestor-e-profissional-de-saude/controle-do-can-cer-de-mama/acoes/deteccao-precoce
17. Rastreamento e Propedêutica do Câncer de Mama. www.febrasgo.org.br. https://www.febrasgo.org.br/pt/compo-nent/zoo/item/rastreamento-e-propedeutica
18. Bretas G, Renna NL, Bines J. Practical considerations for expediting breast cancer treatment in Brazil. The Lancet Regional Health - Americas. 2021;2:100028. doi: https://doi.org/10.1016/j.lana.2021.100028
19. Dados Gerais - ANS - Agência Nacional de Saúde Suplementar. www.ans.gov.br. https://www.ans.gov.br/perfil-do-setor/dados-ge-rais
20. Dados e números sobre câncer de mama. Relatório anual 2022. https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/dados_e_numeros_site_cancer_mama_setembro2022.pdf
21. Rosa DD, Bines J, Werutsky G, et al. The impact of sociodemographic factors and health insurance cov-erage in the diagnosis and clinicopathological char-acteristics of breast cancer in Brazil: AMAZONA III study (GBECAM 0115). Breast Cancer Research and Treatment. 2020;183(3):749-757. doi: https://doi.org/10.1007/s10549-020-05831-y
22. Mathew A, George PS, Kunnambath R, et al. Educa-tional Status, Cancer Stage, and Survival in South In¬dia: A Population-Based Study. JCO Global Oncol¬ogy. 2020;(6):1704-1711. doi: https://doi.org/10.1200/go.20.00259
23. Fonseca B de P, Albuquerque PC, Saldanha R de F, Zicker F. Geographic accessibility to cancer treatment in Brazil: A network analysis. The Lancet Regional Health - Americas. 2022;7:100153. doi: https://doi.org/10.1016/j.lana.2021.100153
24. Santos M de O. Estimativa 2018: Incidência de Câncer no Brasil. Revista Brasileira de Cancerologia. 2018;64(1):119-120. doi: https://doi.org/10.32635/2176-9745.rbc.2018v64n1.115
25. Dados e Números sobre Câncer de Mama - Relatório Anual 2023. INCA - Instituto Nacional de Câncer. Pub¬lished September 29, 2022. https://www.inca.gov.br/publi-cacoes/relatorios/dados-e-numeros-sobre-cancer-de-mama-relatorio-anual-2023
26. Simon SD, Bines J, Werutsky G, et al. Characteristics and prognosis of stage I-III breast cancer subtypes in Brazil: The AMAZONA retrospective cohort study. The Breast. 2019;44:113-119. doi: https://doi.org/10.1016/j.breast.2019.01.008
27. Miglioretti DL, Zhu W, Kerlikowske K, et al. Breast Tu¬mor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Menopausal Status. JAMA Oncology. 2015;1(8):1069-1077. doi: https://doi.org/10.1001/jamaoncol.2015.3084
28. Ailton Augustinho Marchi, Salete M. Adesão ao rastreamento mamográfico oportunístico em serviços de saúde públicos e privados. Revista Brasileira de Ginecologia e Obstetrícia. 2010;32(4). doi: https://doi.org/10.1590/s0100-72032010000400007
29. dos-Santos-Silva I, De Stavola BL, Renna NL, et al. Ethnoracial and social trends in breast cancer staging at diagnosis in Brazil, 2001–14: a case only analy¬sis. The Lancet Global Health. 2019;7(6):e784-e797. doi: https://doi.org/10.1016/s2214-109x(19)30151-2
30. Alves Soares Ferreira N, Melo Figueiredo de Car-valho S, Engrácia Valenti V, et al. Treatment delays among women with breast cancer in a low socio-eco¬nomic status region in Brazil. BMC Women’s Health. 2017;17(1). doi: https://doi.org/10.1186/s12905-016-0359-6
31. Tratamento. Ministério da Saúde. https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/c/cancer-de-mama/tratamento
32. TabnetBD 1.0 - Painel-Oncologia - Brasil. Data-sus.gov.br. Published 2020. http://tab¬net.data-sus.gov.br/cgi/webt-abx.exe?Painel_Onco/Painel_Oncologiabr.Def
33. Santaella T. Santa Catarina apresenta 2° maior crescimento em número absoluto da população no Censo 2022 - Agência de Notícias SECOM. Agência de Notícias SECOM. Published June 28, 2023. https://estado.sc.gov.br/noticias/santa-catarina-apresenta-segundo-maior-crescimento-em-numero-absoluto-de-populacao-no-censo-2022/
34. Fábio Aleixo. Orçamento da Saúde cresceu apenas 2,5% em 10 anos, revela pesquisa do IEPS e Umane - IEPS. Published May 8, 2023. https://ieps.org.br/orcamento-da-saude-cresceu-apenas-25-em-10-anos-revela-pesquisa-do-ieps-e-umane/
35. LEI No 12.732, DE 22 De Novembro De 2012. Planalto.gov.br. Published 2022. https://www.planalto.gov.br/ccivil_03/_ato2011-2014/2012/lei/l12732.htm