Current Review on H2S Signaling

Hydrogen Sulfide, a pungent gas traditionally thought to be toxic to the human body, is now emerging as one of the most important endogenously synthesized gaseous transmitters. Over the course of the past decade, we have witnessed better characterization of its synthetic pathways, discovered how it affects its targets at the molecular level by modifying cysteine residues, a process termed sulfhydration, as well as begun to identify the critical role it plays in the modulation of various cellular processes. In this article, we will review some of these findings.