Temporal Trend of Breast Cancer Diagnoses in Young Women in Different Regions of Brazil from 2014 to 2022
Main Article Content
Abstract
Introduction: Breast cancer is the leading cause of female mortality in Brazil, and in young women, it generally presents more aggressively, with unfavorable characteristics, advanced stages, and a higher risk of recurrence.
Objective: To analyze the temporal trend of diagnosed breast cancer cases in young women in different regions of Brazil from 2014 to 2022.
Methods: An ecological time-series study using data from the Cancer Information System (SISCAN) of the Department of Informatics of the Unified Health System from 2014 to 2022. Reported cases of breast cancer according to ICD-10 C50 were included. For statistical analysis, standardized coefficients and simple linear regression were used.
Results: An increasing trend in the overall diagnosis rate of breast cancer in young women (β=0.719; p<0.001). Increase in diagnoses in all regions, especially in the North region (β=0.888; p<0.001). Increment in all age groups, particularly among those aged 25 to 29 years, with the age group 40 to 44 years (β=1.817; p<0.001) having the highest rates. A major increase in cases of Carcinoma In Situ (β=0.047; p<0.001), with Ductal Carcinoma (β=0.394; p<0.001) being the most incident during the period.
Conclusion: The data show an increase in the rate of breast cancer in young women in Brazil, across all regions, age groups, and histological types. This highlights the need for a better epidemiological understanding of the disease to develop strategies that reduce the associated morbidity and mortality.
Keywords:
Cancer, Breast cancer, Young women, Epidemiology
Article Details
How to Cite
SILVA, Gabriele de Sousa et al.
Temporal Trend of Breast Cancer Diagnoses in Young Women in Different Regions of Brazil from 2014 to 2022.
Medical Research Archives, [S.l.], v. 13, n. 3, mar. 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6441>. Date accessed: 06 apr. 2025.
doi: https://doi.org/10.18103/mra.v3i3.6441.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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3. Yoshida K, Miki Y. Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage. Cancer Sci. 2004;95(11):866-871. doi:10.1111/j.1349-7006.2004.tb02195.
4. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a Cancer Journal for Clinicians. 2021;71(3):209-249. doi:https://doi.org/10.3322/caac.21660
5. Alcantara LL de M, Tomazelli JG, Zeferino FRG, Oliveira BFA de, Silva GA e. Tendência Temporal da Cobertura de Mamografias no Sistema Único de Saúde, Brasil, 2010-2019. ninhoincagovbr. 2022;68(2176-9745). https://ninho.inca.gov.br/jspui/handle/123456789/10229
6. Ministério da Saúde (Brasil), Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA. Estimativa 2022: Incidência de câncer no Brasil. Acessado March 20, 2023. Available at: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//dados_e_numeros_site_cancer_mama_setembro2022.pdf.
7. Ministério da Saúde (Brasil), Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA. Estimativa 2023: Incidência de câncer no Brasil. Acessado March 20, 2023. Available at: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2023.pdf.
8. Ministério da Saúde (Brasil), Instituto Nacional de Câncer José Alencar Gomes da Silva – INCA. Coordenação Geral de Prevenção e Vigilância, Divisão de Detecção Precoce e Apoio à Organização de Rede. Ficha técnica de indicadores relativos às ações do câncer de mama; 2014. Acessado March 20, 2023. Available at: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/ficha-tecnica-indicadores-mama-2014.pdf.
9. Pecinato V, Jacobo A, Silva SG da. Tendência temporal de mortalidade por neoplasia maligna de mama e de colo de útero em Passo Fundo, Rio Grande do Sul: uma análise segundo faixa etária e escolaridade, 1999-2019. Epidemiologia e Serviços de Saúde. 2023;31(2237-9622):e2022440. doi:https://doi.org/10.1590/s2237-9622202200030002.
10. Dutra MC, Rezende MA, Andrade VP de, et al.. Imunofenótipo e evolução de câncer de mama: comparação entre mulheres muito jovens e mulheres na pós-menopausa. Rev Bras Ginecol Obstet. 2009;31(2):54-60. doi:10.1590/S0100-72032009000200002
11. Stival RS, Prestes AL, Mansani FP. Câncer de mama em mulheres jovens: uma análise do estadiamento clínico inicial e dos subtipos moleculares dos tumores. Rev Bras Mastologia. 2014;24(1):17-22. doi:10.5327/z201400010004rbm
12. Pollán M. Epidemiology of breast cancer in young women. Breast Cancer Res Treat. 2010;123 Suppl 1:3-6. doi:10.1007/s10549-010-1098-2
13. Yamashita H, Iwase H, Toyama T, et al. Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis. Ann Oncol. 2011;22(6):1318-1325. doi:10.1093/annonc/mdq596
14. Anders CK, Hsu DS, Broadwater G, et al. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression [published correction appears in J Clin Oncol. 2011 Sep 20;29(27):3721]. J Clin Oncol. 2008;26(20):3324-3330. doi:10.1200/JCO.2007.14.2471
15. Soares PB, Quirino Filho S, Souza WP et al. Características das mulheres com câncer de mama assistidas em serviços de referência do Norte de Minas Gerais. Rev Bras Epidemiologia. 2012;15(3):595-604. doi:10.1590/s1415-790x2012000300013
16. Soerjomataram I, Louwman MW, Ribot JG, Roukema JA, Coebergh JW. An overview of prognostic factors for long-term survivors of breast cancer. Breast CancerRes Treat. 2008;107(3):309-330. doi:10.1007/s10549-007-9556-1
17. Rossi L, Mazzara C, Pagani O. Diagnosis and Treatment of Breast Cancer in Young Women. Current Treatment Options in Oncology. 2019;20(12). doi:https://doi.org/10.1007/s11864-019-0685-7
18. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Internation al Journal of Cancer. 2015;136(5):E359-E386. doi:https://doi.org/10.1002/ijc.29210
19. Villarreal-Garza C, Aguila C, Magallanes-Hoyos MC, et al. Breast cancer in young women in Latin America: an unmet, growing burden. The Oncologist. 2013;18 Suppl(S2):26-34. doi:https://doi.org/10.1634/theoncologist.18-S2-26
20. Eugênio DSG, Souza JA, Chojniak R, Bitencourt AGV, Graziano L, Souza EF. Breast cancer features in women under the age of 40 years. Revista da Associação Médica Brasileira. 2016;62(8):755-761. doi:https://doi.org/10.1590/1806-9282.62.08.755
21. Franco-Marina F, López-Carrillo L, Keating NL, Arreola-Ornelas H, Marie Knaul F. Breast cancer age at diagnosis patterns in four Latin American Populations: A comparison with North American countries. Cancer Epidemiology. 2015;39(6):831-837. doi:https://doi.org/10.1016/j.canep.2015.10.004
22. Garicochea B, Morelle A, Ana Elisa Andrighetti, Cancella A, Ângelo Bós, Werutsky G. Idade como fator prognóstico no câncer de mama em estádio inicial. Revista de saúde pública/Revista de Saúde Pública. 2009;43(2):311-317. doi:https://doi.org/10.1590/s0034-89102009005000009
23. Crippa CG. Câncer de Mama Em Mulheres Jovens: Estudo de Probabilidade de Sobrevida Livre de Doença .; 2002. Accessed January 23, 2025. https://repositorio.ufsc.br/bitstream/handle/123456789/84048/PMED0033-D.pdf?sequence=1
24. Hindle WH, Davis L, Wright D. Clinical value of mammography for symptomatic women 35 years of age and younger. American Journal of Obstetrics and Gynecology. 1999;180(6):1484-1490. doi:https://doi.org/10.1016/s0002-9378(99)70043-8
25. Sirovich BE, Sox HC. Breast Cancer Screening. Surgical Clinics of North America. 1999;79(5):961-990. doi:https://doi.org/10.1016/S0039-6109(05)70056-6
26. King MC, Rowell S, Love SM. Inherited breast and ovarian cancer. What are the risks? What are the choices? JAMA. 1993;269(15):1975-1980. doi:https://doi.org/10.1001/jama.269.15.1975
27. Kelsey JL, Gammon MD, John EM. Etiology of breast cancer. Cancer. 1990;65(5):1242-1251. doi:10.1002/1097_0142(19900301)65:5<1242::AID-CNCR2820650535>3.0.CO;2-1.
28. Gonzaga CMR. Mortalidade por câncer de mama nas mulheres brasileiras no período de 1980 a 2009. Biblioteca digital de teses e dissertações. Published September 30, 2011. Accessed March 20, 2024. http://repositorio.bc.ufg.br/tede/handle/tde/1750
29. Rocha-Brischiliari SC, Oliveira RR de, Andrade L, et al. The Rise in Mortality from Breast Cancer in Young Women: Trend Analysis in Brazil. Ahmad A, ed. PLOS ONE. 2017;12(1):e0168950. doi:https://doi.org/10.1371/journal.pone.0168950
30. Barbosa IR, Costa I do CC, Pérez MMB, Souza DLB de. Mortalidade por câncer de mama nos estados do nordeste do Brasil: Tendências atuais e projeções até 2030. Revista Ciência Plural. 2015;1(1):04-14. https://periodicos.ufrn.br/rcp/article/view/7318
31. Soares P dos R. Tendência Temporal de Mortalidade Por Câncer de Mama Em Mulheres No Brasil de 2000 a 2017.; 2020. Accessed March 20, 2023. https://repositorio.animaeducacao.com.br/bitstream/ANIMA/15444/1/artigo%20cient%c3%adfico%20P%c3%a2mela%20dos%20Reis%20Soares.pdf
32. Fitzmaurice C, Dicker D, Pain A, et al. The Global Burden of Cancer 2013. JAMA oncology. 2015;1(4):505-527. doi:https://doi.org/10.1001/jamaoncol.2015.0735
33. The International Agency for Research on Cancer (IARC). Global Cancer Observatory. gco.iarc.fr. Published 2022. https://gco.iarc.fr/en
34. Azevedo e Silva G, Bustamante-Teixeira MT, Aquino EML, Tomazelli JG, dos-Santos-Silva I. Acesso à detecção precoce do câncer de mama no Sistema Único de Saúde: uma análise a partir dos dados do Sistema de Informações em Saúde. Cadernos de Saúde Pública. 2014;30(7):1537-1550. doi:https://doi.org/10.1590/0102-311x00156513
35. Guindalini RSC, Viana DV, Kitajima JPFW, et al. Detection of germline variants in Brazilian breast cancer patients using multigene panel testing. Scientific Reports. 2022;12(1):4190. doi:https://doi.org/10.1038/s41598-022-07383-1
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