Alternative Medicine in Treatment of Oral Cancer: Insights and Advances
Main Article Content
Nevica Baruah, MDS, Oral Medicine and Radiology
http://orcid.org/0000-0001-9304-8545
Anisha Yaji, MDS, Oral Medicine and Radiology
http://orcid.org/0000-0003-0198-3507
Smrithy Muraleedharan, MDS, Oral Medicine and Radiology
http://orcid.org/0009-0003-5388-7522
Bhavana Manjunath Bhat, Pharm D
http://orcid.org/0009-0004-0384-0993
http://orcid.org/0000-0001-9304-8545
Anisha Yaji, MDS, Oral Medicine and Radiology
http://orcid.org/0000-0003-0198-3507
Smrithy Muraleedharan, MDS, Oral Medicine and Radiology
http://orcid.org/0009-0003-5388-7522
Bhavana Manjunath Bhat, Pharm D
http://orcid.org/0009-0004-0384-0993
Abstract
Oral squamous cell carcinoma continues to pose a major clinical challenge, as even the most advanced treatment options are often associated with significant toxicity and poor long-term outcomes. This study investigates the potential of integrating alternative medicine into existing treatment paradigms, addressing the question of whether alternative therapies can enhance patient outcomes in oral cancer treatment.
A non-systematic review was conducted analysing 21 alternative medicines and their efficacy as mainstay treatment, as well as adjuvant therapy for oral squamous cell carcinoma, focusing on their mechanisms of action, current research status, and future clinical applicability. Significant findings revealed that herbal remedies such as curcumin, celastrol, saffron, and quercetin demonstrate multi-targeted effects, including induction of apoptosis, inhibition of tumor proliferation, modulation of inflammatory and immune pathways, epigenetic regulation, and potentially mitigate the adverse effects of standard treatments.
The results indicate that alternative medicine can significantly enhance the efficacy and safety of conventional therapies, supporting a more holistic approach to patient care. However, large scale clinical trials are necessary to establish standard protocols for their use, assess their safety and efficacy, and determine the optimal integration methods. By fostering interdisciplinary collaboration, this study advocates for a comprehensive framework that includes both alternative and conventional medicine in managing oral cancer, ultimately improving patient outcomes and quality of life.
Keywords:
Oral squamous cell carcinoma, Herbal medicine, Chinese medicine, Ayurveda, Phytochemicals, Targeted cancer therapy
Article Details
How to Cite
BARUAH, Nevica et al.
Alternative Medicine in Treatment of Oral Cancer: Insights and Advances.
Medical Research Archives, [S.l.], v. 13, n. 7, july 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6528>. Date accessed: 05 dec. 2025.
doi: https://doi.org/10.18103/mra.v13i7.6528.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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4. Bendowska A, Baum E. The Significance of Cooperation in Interdisciplinary Health Care Teams as Perceived by Polish Medical Students. Int J Environ Res Public Health. 2023;20(2). doi:10.3390/ijerph20020954
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6. Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic Applications of Herbal Medicines for Cancer Patients. Evidence-Based Complementary and Alternative Medicine. 2013;2013:1-15. doi:10.1155 /2013/302426
7. Ratha KK, Misra SR, Das R. Traditional ayurvedic medicine as a therapeutic option in oral cancer: An alternative medicine perspective. Oral Oncology Reports. 2024;9:100207. doi:10.1016/j.oor.2024.100207
8. Patel SM, Nagulapalli Venkata KC, Bhattacharyya P, Sethi G, Bishayee A. Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases. Semin Cancer Biol. 2016;40-41:100-115. doi:10.1016/j.semcancer.2016.03.002
9. Agrawal S, Bablani Popli D, Sircar K, Chowdhry A. A review of the anticancer activity of Azadirachta indica (Neem) in oral cancer. J Oral Biol Craniofac Res. 2020;10(2):206-209. doi:10.1016/j.jobcr.2020.04.007
10. Morris J, Gonzales CB, De La Chapa JJ, et al. The Highly Pure Neem Leaf Extract, SCNE, Inhibits Tumorigenesis in Oral Squamous Cell Carcinoma via Disruption of Pro-tumor Inflammatory Cytokines and Cell Signaling. Front Oncol. 2019;9:890. doi:10.3389/fonc.2019.00890
11. Roberti di Sarsina P, Tassinari M. Integrative approaches for health: Biomedical research, ayurveda, and yoga. J Ayurveda Integr Med. 2015; 6(3):213-214.
12. Wongnoppavich A, Kanjana J, Sireeratawong S. Triphala: The Thai traditional herbal formulation for cancer treatment. Songklanakarin J Sci Technol. 2009;31(2):139-149.
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