Abstract
TVE demonstrates significant therapeutic potential in wound care and gynecology due to its various biological properties.
In wound care, TVE exhibits mitogenic and proliferative effects on fibroblasts and keratinocytes, enhancing tissue regeneration and wound healing. It also possesses anti-inflammatory properties by reducing pro-inflammatory markers and inhibiting NF-kB activation. The regenerative activity is further supported by its ability to induce fibronectin expression, increase hyaluronan synthesis, and stimulate actin polymerization. Mechanistically, TVE shows antioxidant capacity and promotes keratinocyte healing by modulating MMP-2, MMP-9, collagen I, and elastin expression. Clinically, TVE formulations have been effective in treating acute skin wounds, diabetic foot ulcers (DFUs), and split-thickness skin graft donor sites (STSG), often showing superior results compared to hyaluronic acid treatments.
In gynecology, TVE formulations have been beneficial in vulvovaginal atrophy (VVA), vulvovaginitis, and cervical ectropion, demonstrating significant symptom reduction and high patient satisfaction. The studies reviewed indicate that TVE is a versatile and effective treatment option in these areas.
Overall, the evidence presented suggests that TVE, particularly in the form of Fitostimoline® products, offers a valuable non-hormonal alternative with significant regenerative and anti-inflammatory properties, making it a promising treatment for various conditions in wound care and gynecology.