Association of Gerd with Obesity & the Waist Circumference “A Reflux or Reflex Affair!

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Uwais Riaz Ul Hasan, M.Med Khathija Hasan, M.Med Shehla Riaz Ul Hasan Abdul Rahman Al Gannam Ammar Al Sulaiman Shehab Yousef Buhulaigah Aissa Saidi Amith Ibrahim Yousef Habib Almusharraf Mohammed Aldraisi Hussain Turky Alturiky Khalil Ibrahim AlShaqaqiq Ahmed Abdullah Ali Aeisa Sarah Mohammed AlKuwayti Ali Abdullah Mohammed AlShagag Eman Hussain Albasrawi Amjad Adnan AlMousa Ali Hussain Albasrawi Abdul Raheem Alkhalaf

Abstract

Gastroesophageal reflux disease (GERD) is a digestive disorder that affects the lower oesophageal sphincter and causes injury to the oesophagus from chronic reflux exposure to stomach acid. Gastroesophageal reflux disease is one of the most common health problems in the world today. Up to 80% of the patients with reflux disease experience difficulty in sleeping, working and eating thereby contributing to an impaired quality of life. The financial burden of GERD Gastroesophageal reflux disease on the health sector is enormous. World wide GERD is increasingly and of late is being reported from Asia and south east Asian countries. The relationship of GERD with obesity is assumed but the evidence is equivocal. Substantial studies that report an association between the two and an equal number concluding that there is no association between GERD and obesity.


In Malaysia Obesity is on the rise among its residents the Malay, the Chinese and among the Indian population. A cross sectional study was therefore conducted to establish an association if any between moderate & severe GERD versus Obesity and Waist circumference.


Results: A total of one hundred and fifty five subjects had GERD, Among the one hundred and fifty five, 111 subjects were obese, only forty four had a normal body mass index. The Obese subjects in both the moderate and severe categories had varying grades of obesity I-III. The majority of the obese were among the Malay population. The Body mass index and waist circumference was noted to be higher than their Chinese counterparts.


In this study five subjects were noted to have Non erosive reflux disease (NERD). A total of seventeen patients had Barrett oesophagus nine of whom were males. Interestingly the severity of the self reported Clinical symptoms in those patients with Barrett oesophagus was less. The current trend in the rise of obesity with its co morbidities and the increasing prevalence of gastroesophageal reflux disease is likely to impose huge financial costs that will impact economy of the health care sector of many developing nations including Malaysia in this part of the world.


Conclusion: Obesity is on the rise worldwide as is witnessed in Malaysia. GERD and non erosive reflux disease is prevalent among the population in Kelantan. Body mass index and waist circumference were not found to be associated with the severity of GERD in both the moderate and severe categories.

Keywords: Gastroesophageal reflux disease (GERD), Obesity, Reflux, Waist Circumference, BMI

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How to Cite
UL HASAN, Uwais Riaz et al. Association of Gerd with Obesity & the Waist Circumference “A Reflux or Reflex Affair!. Medical Research Archives, [S.l.], v. 13, n. 8, aug. 2025. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/6759>. Date accessed: 05 dec. 2025. doi: https://doi.org/10.18103/mra.v13i8.6759.
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Research Articles

References

[1] Vakil N, Van Zanten SV, Kahrilas P, Dent J et al (2006) and the global consesus group. The montreal definition and classification of gastroesophageal reflux disease: a global evidence based consensus. Am J Gastroenterol 101 1900-20.
[2] Dent J, EL Serag HB, Wallander MA, et al. (2005) Epidemiology of gastroesophageal reflux disease: A systematic review. Gut 54 710-713.
[3] Nandurkar S, Locke GR, 3rd, Fett S et al, Cameron AJ, Talley NJ (2005). Aliment Pharmacol Therapy Sept 20 (5) 497-505.
[4] Sandler RS, Everhart JE, Donowitz M (2002). The burden of selected digestive disorders in the United States. Gastroenterology 5 1500-1511.
[5] B.C.Y. Wong and Y. Kinoshita, (2006). Systematic review on epidemiology of gastroesophageal reflux disease in Asia, Clinic Gastroenterology & Hepatol 398-407.
[6]. Tamas G Toth, Pal Demeter et al (2004). Does Body Mass Index associate with endoscopic severity of gastroesophageal reflux disease? Int J Diabetes & metabolism 12 49-52.
[7] Beck IT. (1970). Determination of acid sensitivity, mucosal damage and oesophagitis. Mod treat. 7 1120-1135.
[8] Mittal RK, Balaban DH. (1997) The oesophagogastric junction. N Engl J Med. Mar 27 336 (13) 924-932.
[9] Hill LD, Kozarek RA, Kraemer SJ (1996). The gastroesophageal flap valve: in vitro and vivo observations. Gastrointest Endoscope 44 (5) 541-547.
[10] Dent J, Dodds WJ Friedman RH et al. (1980) Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest. 65 (2) 256-267.
[11] Helm JF, Dodds WJ, Pelc LR, et al(1984) Effect of oesophageal emptying and saliva on the clearance of acid from the oesophagus. N Eng J Medicine 310 284-288.
[12] Howden CW (1994). Appropriate acid suppression in the treatment of acid related conditions. Alim Pharmacol Ther. 63 (1) 123-134.
[13] Brandt MG, Darling GE, Miller L (2004). Symptoms acid exposure and motility in patients with Barrett`s oesophagus. Can J Surg. 47 (1) 47-51.
[14] Buckles DC, Sarosiek I, Mc Millin C et al (2004-2006) Delayed gastric emptying in gastroesophageal disease: reassessment with new methods and symptomatic correlations. Am J Med Sci. 327 (1) :1-4. Oesophagus: what it is and what it tells us. Eur Surg 38 197-209.
[15] Holloway RH, Hongo M, Berger K et al (1985) Delayed gastric distension: A mechanism for postprandial gastroesophageal reflux. Gastroenterology 89 (4) 779-784.
[16] Jones MP, Solan SS, Rabine JC et al (2001). Hiatal hernia size a dominant determinant of oesophagitis presence and severity in gastroesophageal reflux disease. Am J Gastroenterology 96 (6) 1711-1717.
[17] Boesby S. Gastro esophageal sphincter pressure motility and acid clearing.(1977). A study of hiatus hernia patients and normal subjects and of a effect of a modified belsy MK IV repair on the results of the manometric and acid clearing tests. Scad Journal Gastroenterology 12 (4) 407-416.
[18] Lagergren J, Bergstrom R, Nyren O (2000) No relation between body mass and gastro esophageal reflux symptoms in the Swedish population based study. Gut 47 26-29.
[19] Mohammed I, Cherkas LF, Riley SA et al (2003). Genetic influences in gastroesophageal reflux disease: A twin study Gut 52 (8) 1085 -1089.
[20] Post JC, Ze F, Ehrlich GD. (2005) Genetics of pediatric gastroesophageal reflux. Current opinion Allergy Clinic Immunology, 5 5-9.
[21] Fung WP. (1970). Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation. Gut,11 955-961.22)
[22] Kinoshita Y, Kawanami C, Kishi K et al (1997). Helico.pylori independent chronological change in gastric acid secretion in the Japanese, Gut 41 452-8.
[23] Ho KY, Kang JY, Seow A (1998). A Prevalence of gastroesophageal symptoms in a multiracial Asian population, with reference to reflux type symptoms. Am J Gastroenterol. 93, 1816-22.

[24] Ho KY, Chan YH, Kang JY. (2005). Increasing trend of reflux oesophagitis and the decreasing trend of Helicobacter pylori infection in patients from a multicentric Asian country. Am Journal of Gastroenterology 100 1923-28.
[25] Howard Hampel, Neena S Abraham, Hashem El Serag (2005) MetaAnalysis: Obesity and the risk for Gastroesophageal reflux disease and its complications. Ann Inter n Med. 143 199-211.
[26] Kahrilas PJ.(1999) The role of hiatus hernia in Gastroesophageal reflux disease.Yale Journal Bio Med. 72 101-11.
[27] James WPT, Chunming C, Inoue S (2002). Appropriate Asian body mass indices? Obesity reviews 3 (3) 139.
[28] Pandolfino JE, El Serag HB, Zang Q (2006). Obesity :A challenge to the oesophagogastric junction integrity. Gastroenterology 130 639-649.
[29] Tselepis C, Perry I, Dawson C (2002). Tumor necrosis factor-alpha in Barrett`s oesophagus: A novel mechanism of action. Oncogene 21 6071-6081.
[30] Nilsson M, Johnsen R, Yew et al (2003). Obesity and oestrogen as risk factors for symptomatic gastroesophageal reflux. JAMA 290 66-72.
[31] Weiner CP, Lizasoain I, Baylis SA et al (1994), Induction of calcium dependent nitric oxide by sex hormones. Proc Natl Acad Sci, Usa 91 (11) 5212-5216.
[32] Kadakia SC, Kikendall JW, Maydonowitch C et al (1995) Effect of cigarette smoking on gastroesophageal reflux measured by 24 hr ambulatory oesophageal pH monitoring. Am Journal Gastroenterology 90 (10) 1785-1790.
[33] Bujanda L (2000) The effects of alcohol consumption upon the gastroesophageal tract. Am Journal Gastroenterology 95 3374-3382.
[34] Nandurkar S, Locke GR, 3rd, Fett SZinsmeister et al (2004). Relationship between body mass index, diet, exercise, and gastroesophageal reflux disease in a community. Aliment Pharmacol Therapy Sept 20 (5) 497-505.
[35] Hills JM, Aaronson PI. (1991). The mechanism of action of peppermint oil on gastrointestinal smooth muscle. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig. Gastroenterology 101 (1) 55-56.
[36] Kaltenbach T, Crockett S, Gerson LB. (2006) Are life style measures effective in patients with gastroesophageal reflux disease? An evidence based approach. Arch Intern Med. 166 (9) 965-971.
[37] Palombini BC, Viallanova CA, Araujo E (1999).A pathogenic triad in chronic cough, asthma, postnasal drip syndrome and gastroesophageal reflux disease. Chest Aug 116 (2) 279-284.
[38] Moote DW, Lloyd DA, McCourtie DR, Wells GA (1986). Increase in gastroesophageal reflux during methacholine induced bronchospasm. J Allergy Clin Immunology Oct 78 (4pt1) 619-623.
[39] Fass R, Shapiro M, Dekel R, Sewell J (2005). Systematic review: Proton pump inhibitor failure in gastroesophageal reflux disease-where next? Aliment Pharmac Therapy 22 79-34
[40] Fass R, Ofman JJ (2002). Gastroesophageal reflux disease should we adopt a new conceptual framework? Am Journal Gastroenterology 97 1901-1909.
[41] Allison PR, Johnstone AS. (1953). The oesophagus lined with gastric mucous membrane. Thorax, 87 90-101.
[42] Norton K, Whittingham, N.Carter et al (1996), Measurement technique in anthropometry. In:Norton,K.Olds.T(Eds). Antropometrica Sydney, NSW: University of NSW press pg 20-6.
[43] McCarthy, H.D., Ellis, S.M., & Cole, T.J (2003). Central overweight and obesity in British youth aged 11-16 years: cross sectional surveys of waist circumference. British Medical Journal, 326, 624-627.
[44] He M Kung AWC, Tan KCB, Li ETS (2001). Body fat determinations by dual energy X ray absorptiometry and its relation to body mass index and waist circumference in Hong Kong Chinese. International Journal of Obesity 25 748-752.
[45] Yoshiike N, Seino F, Tajima S et al (2002). Twenty year changes in the prevalence of overweight in Japanese adults: the National Nutrition Survey 1976-95. Obesity reviews 3 (3) 183-90.
[46] Tan CE, Ma S, Wai D, Chew SK et al (2004). Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome in Asians? Diabetes Care 27 1182-86.
[47] Jia H, Lubetkin El (2005). The impact of Public obesity on health related quality of life in the general adult us population. Journal Health 25 156-64.
[48] Yancy WS Jr, Olsen MK, Westman EC, (2002). Relationship between obesity and health related quality of life in men. Obesity Res 10 1057-64.
[49] Vicente Ortiz, Marta Ponce, Alberto Fernandez et al (2006). Value of Heartburn for diagnosing Gastroesophageal reflux disease in Severely Obese patients. Obesity 14 696-700.
[50] MGH van Oijen, DFGM Josemanders, RJF Laheij et al (2006). Gastrointestinal disorders and symptoms: Does body mass index matter? The journal of Medicine Netherlands 64 112-113.