Lifestylopathy: A Thermodynamic Framework for Immune Regulation and Health Restoration
Main Article Content
Abstract
Lifestylopathy introduces a novel thermodynamic framework for understanding immune health as a function of energy dynamics, entropy regulation, and lifestyle coherence. Anchored in the principles of physics, systems biology, and psychoneuroimmunology, this model reconceptualizes health as the body’s capacity to maintain internal order and regenerate through five interdependent domains of potential energy: chemical, physical, mental, voluntary, and restorative. Each domain contributes to the balance between potential energy and entropy, shaping immune responsiveness and metabolic efficiency. The immune system is reframed not only as a defence mechanism but as a dynamic mirror of the body’s energetic state, shifting between optimal “fight mode” and dysfunctional “fright” or “flight” responses based on lifestyle signals. When energy is well-regulated, the immune system operates in a state of homeodynamic readiness, capable of both protection and repair. However, chronic stress, poor nutrition, disconnection, and emotional misalignment can tip this balance, leading to inflammation, suppression, or breakdown. Lifestylopathy offers a personalized, integrative approach to health recovery, emphasizing lifestyle interventions as precision tools to restore thermodynamic harmony, promote immune clarity, and enhance long-term resilience.
Keywords:
Lifestylopathy, Thermodynamic health, Entropy regulation, Potential energy, Immune resilience, Personalized lifestyle medicine
Article Details
How to Cite
ALZEER, Jawad et al.
Lifestylopathy: A Thermodynamic Framework for Immune Regulation and Health Restoration.
Medical Research Archives, [S.l.], v. 13, n. 7, july 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6774>. Date accessed: 05 dec. 2025.
doi: https://doi.org/10.18103/mra.v13i7.6774.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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14. Millen J, Xuereb A. Perspective on quantum thermodynamics. New J Phys. 2016;18(1):011002. https://doi.org/10.1088/1367-2630/18/1/011002
15. Lee A, Dixit V. Dietary regulation of immunity. Immunity. 2020;53(3):510–523. https://doi.org/10.1016/j.immuni.2020.08.013
16. Gutiérrez S, Svahn S, Johansson M. Effects of omega-3 fatty acids on immune cells. Int J Mol Sci. 2019;20(20):5028. https://doi.org/10.3390/ijms20205028
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18. Günal‐Köroğlu D, Karabulut G, Özkan G, Yılmaz H, Subaşı BG, Çapanoğlu E. Allergenicity of alternative proteins: reduction mechanisms and processing strategies. J Agric Food Chem. 2025;73(13):7522–7546. https://doi.org/10.1021/acs.jafc.5c00948
19. Barnaba V, Paroli M, Piconese S. The ambiguity in immunology. Front Immunol. 2012;3. https://doi.org/10.3389/fimmu.2012.00018
20. Lévesque S, Pol J, Ferrere G, Galluzzi L, Zitvogel L, Kroemer G. Trial watch: dietary interventions for cancer therapy. Oncoimmunology. 2019;8(7):e1591878. https://doi.org/10.1080/2162402x.2019.1591878
21. Dünkelberg S, Maywald M, Schmitt A, Schwerdtle T, Meyer S, Rink L. The interaction of sodium and zinc in the priming of T cell subpopulations regarding Th17 and Treg cells. Mol Nutr Food Res. 2020;64(2). https://doi.org/10.1002/mnfr.201900245
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23. Zheng L, Wang Z, Zhang X, Ning K. Myokines may be the answer to the beneficial immunomodulation of tailored exercise—a narrative review. Biomolecules. 2024;14(10):1205. https://doi.org/10.3390/biom14101205
24. Woodyard CD. Exploring the therapeutic effects of yoga and its ability to increase quality of life. Int J Yoga. 2011;4(2):49. https://doi.org/10.4103/0973-6131.85485
25. Raub JA. Psychophysiologic effects of hatha yoga on musculoskeletal and cardiopulmonary function: a literature review. J Altern Complement Med. 2002;8(6):797–812. https://doi.org/10.1089/10755530260511810
26. Kuśmierska M, Kuśmierski J, Janik I, Martyka A, Ujma P. Mindfulness and movement: scientifically exploring the health impacts of yoga. J Educ Health Sport. 2024;64:206–220. https://doi.org/10.12775/jehs.2024.64.014
27. Souza ACR, Bentes CM, Salles BF, Reis VM, Vilaça‐Alves J, Miranda H, et al. Influence of inter-set stretching on strength, flexibility and hormonal adaptations. J Hum Kinet. 2013;36(1):127–135. https://doi.org/10.2478/hukin-2013-0013
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29. Hu Q. Impacts of intermittent high-intensity training on aerobics students’ performance. Rev Bras Med Esporte. 2023;29. https://doi.org/10.1590/1517-8692202329012023_0068
30. Hu D, Wan L, Chen M, Caudle Y, LeSage G, Li Q, et al. Essential role of IL-10/STAT3 in chronic stress-induced immune suppression. Brain Behav Immun. 2014;36:118–127. https://doi.org/10.1016/j.bbi.2013.10.016
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36. Klose CSN, Veiga‐Fernandes H. Neuroimmune interactions in peripheral tissues. Eur J Immunol. 2021;51(7):1602–1614. https://doi.org/10.1002/eji.202048812
37. Schneider FM, Borchmann D. Topological entropy of formal languages. Semigroup Forum. 2016;94(3):556–581. https://doi.org/10.1007/s00233-016-9782-0
38. Wagner D, Bekas K, Bialystok E. Does language entropy shape cognitive performance? A tale of two cities. Biling Lang Cogn. 2023;26(5):998–1008. https://doi.org/10.1017/s1366728923000202
39. Sepalanita W, Faturachman A, Subiakto T. The effect of diaphragmatic breathing exercises on peak expiratory flow rate in bronchial asthma patients. J Kesehatan Manarang. 2024;10(1):59. https://doi.org/10.33490/jkm.v10i1.965
40. Sheeran P, Webb TL. The intention–behavior gap. Soc Personal Psychol Compass. 2016;10(9):503–518. https://doi.org/10.1111/spc3.12265
41. Chopra K, Kumar B, Kuhad A. Pathobiological targets of depression. Expert Opin Ther Targets. 2011;15(4):379–400. https://doi.org/10.1517/14728222.2011.553603
42. Lesseur C, Paquette AG, Marsit CJ. Epigenetic regulation of infant neurobehavioral outcomes. Med Epigenet. 2014;2(2):71–79. https://doi.org/10.1159/000361026
43. Gómez‐Pinilla F, Zhuang Y, Feng J, Ying Z, Fan G. Exercise impacts brain‐derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. Eur J Neurosci. 2010;33(3):383–390. https://doi.org/10.1111/j.1460-9568.2010.07508.x
44. Fung W, Yip P, Stevens S, Wong T, Yoo Y, Ross N, et al. Christian-based spiritually integrated psychotherapy for East Asian Canadians and findings from the CSPEARIT study. Spirituality in Clinical Practice. 2023;10(4):301–324. https://doi.org/10.1037/0000338-016
45. Alzeer J. Harnessing the power of choice: how to thrive in a universe of entropy. Am J Med Chem. 2024;5(1):2–6. https://doi.org/10.31487/j.AJMC.2024.01.02
46. Alzeer J, Benmerabet H. Exploring the intersection of quantum mechanics and human psychology. Psychol Dis Res. 2024;7(1):1–6. https://doi.org/10.31487/j.pdr.2024.01
47. Alzeer J, Benmerabet H. Potentiality to actuality: quantum physics inspires creative innovation. Jurnal Pijar Mipa. 2025;20(1):1–6. https://doi.org/10.29303/jpm.v20i1.8176
48. Wakefield JRH, Bowe M, Këllezi B. Who helps and why? A longitudinal exploration of volunteer role identity, between‐group closeness, and community identification as predictors of coordinated helping during the COVID‐19 pandemic. Br J Soc Psychol. 2022;61(3):907–923. https://doi.org/10.1111/bjso.12523
49. Huang X, Fu M. Voluntary participation mediates the relationship between multi-membership in online communities and life satisfaction among Chinese populations: a gendered perspective. Behav Sci. 2024;14(11):976. https://doi.org/10.3390/bs14110976
50. Hopwood R, Witten T. Spirituality, faith, and religion: the TGNC experience. Spirituality in Clinical Practice. 2017;4(3):213–230. https://doi.org/10.1037/14957-011
51. Alzeer J. Lifestylopathy: a holistic approach to healthcare. J Altern Med Ther. 2024;1(1). https://doi.org/10.59462/jamt.1.1.101
52. Weinhouse C. Mitochondrial-epigenetic crosstalk in environmental toxicology. Toxicology. 2017;391:5–17. https://doi.org/10.1016/j.tox.2017.08.008
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