Is it Possible to Use a Platelet Rich Plasma (PRGF-ENDORET®) in Case of Oral Metastatic Lesions?

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Published Aug 25, 2025
DOI: https://doi.org/10.18103/mra.v13i8.6789

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Main Article Content

Maurizio Stefano Giacomello
School of Dentistry (Director: Prof. M. Baldoni), School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Alberto Giacomello
Private practice
Enrico Rescigno
President-elect of ANTHEC (Academy of Neoregeenrative Therapies and Hemocomponents)
Alberta Greco Lucchina
Research Laboratory in Regenerative Medicine and Tissue Engineering Saint Camillus International University of Healt Sciences, Rome, Italy
Carmen Mortellaro
Research Laboratory in Regenerative Medicine and Tissue Engineering Saint Camillus International University of Healt Sciences, Rome, Italy

Abstract

Aim of the present study is to describe the surgical treatment of a metastatic lesion in mandibular region derived from a prostatic cancer in an old patient, and the benefits of the PRGF®-Endoret®, a particular kind of Platelet Rich Plasma (PRP), on healing processes. The old patient was in a very bad conditions with several medical pathologies, as congestive cardiopathy and chronic kidney distress. Moreover, he was treated with zolendronic acid to block the metastatic bone lesions, a drug that increases the risks to have a BRONJ (bisphosphonates related osteonecrosis of the jaws): in fact, the mandibular lesion was associated with bone necrosis and neuropathic pain from the right mandible to the right ear along the path of the lower alveolar nerve. Moreover, bisphosphonates drugs normally disturb the healing processes of the oral mucosae and gums. The use of PRGF®-Endoret® during the surgical treatments of this case helped to solve the mandibular lesion avoiding the risk of a bad healing. Furthermore, this case shows that in selected cases it is possible to use a PRPs as PRGF®-Endoret® after removal metastatic lesions despite these autologous biomaterials can promote the cancer cells growth. Anyway, in these kinds of problems, the selection of the patients, their life expectancy and their clinical conditions are very important to decide if the benefits are more than the risks associated to the use of PRP. However more studies are necessary to confirm the possibility to use the PRP in the surgical treatment of the cancer or metastatic lesions, exactly because these biomaterials can induce a worsening of the cancer prognosis.

Keywords: osteonecrosis, jaw necrosis, BRONJ, PRGF®-Endoret®, PRP, platelet concentrates, healing improvement, metastatic lesion

Article Details

How to Cite
GIACOMELLO, Maurizio Stefano et al. Is it Possible to Use a Platelet Rich Plasma (PRGF-ENDORET®) in Case of Oral Metastatic Lesions?. Medical Research Archives, [S.l.], v. 13, n. 8, aug. 2025. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/6789>. Date accessed: 14 dec. 2025. doi: https://doi.org/10.18103/mra.v13i8.6789.
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Issue
Vol 13 No 8 (2025): Vol.13, Issue 8, August 2025
Section
Research Articles

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