SEGMENTAL ELECTRICAL BIOIMPEDANCE MYOGRAPHY IN NORMALS AND IN PATIENTS WITH NEUROMUSCULAR DISEASES: A CASE SERIES
Main Article Content
Abstract
Background: Bioimpedance myography is a useful nontraumatic, simple technique that assists in determining muscle mass and is increasingly used to assess muscle atrophy and disease progression. Studies indicate the results are reproducible and show strong correlation with DEXA scans and muscle ultrasound. This technique employs high-frequency, low-intensity electrical stimulation to measure the reactance and resistance of tissue, thereby determining muscle mass.
Methods: We conducted tests on forty-one normal subjects as well as patients with various neuromuscular diseases.
Results: Our study established normal values with variability less than 0.5%, providing examples of several disorders where decreased muscle mass was apparent in patients experiencing atrophy and weakness across different regions of the body. In conclusion, bioimpedance myography is a reliable, non-invasive method for assessing muscle mass, showing strong correlation with DEXA scans. It effectively identifies reduced muscle mass in neuromuscular diseases, aiding clinical evaluations and progression monitoring.
Article Details
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
2. Rutkove SB. Electrical impedance myography: Background, Current state, and future directions. Muscle Nerve 2009;40(6):936-946.
3. Janssen I, Maymsfield S, Baumgartner R, Ross, R. Estimation of skeletal muscle mass bioelectrical impedance analysis. J Appl. Physiol, 2000;89(2): 463-471.
4. Rutkove SB, Kyoungmouk SL, Schiffman CA, Aaron R. Test-Retest Reproducibility of 50kHz Linear-Electrical Impedance Myography. Clin. Neurophys. 2006;117:1244-1248. Doi. 10.1016/j.clinph.2005.
5. Rutkove SB, Geishbush TR, Mijailovic A., et al. Cross-sectional evaluation of electrical impedance myography and quantitative ultrasound for the assessment of Duchenne muscular dystrophy in a clinical trial setting. Pediat Neurol. 2014; 51:88-92. Doi.10.1016/j.pediatneurol.2014;02.015.12.029
6. Roy B, Darras BT, Zaidman CM, Wu JS, Kapur K, Rutkove SB. Exploring the relationship between electrical impedance myography and quantitative ultrasound parameters in Duchenne muscular dystrophy. Clin Neurophysiol. 2019;130-:515-520.
7. Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002;57:M772- M777
8. Zaidman CM, Wang LL, Connolly AM, et al. Electrical impedance myography in Duchenne muscular dystrophy and healthy controls: a multi-center study of reliability and validity. Muscle Nerve. 2015; 52:592-597.
9. Rutkove SB, Shefner JM, Gregas M, et al. Characterizing spinal muscular atrophy with electrical impedance myography. Muscle Nerve. 2020;42: 915-921.doi:10.1001/mus.21784.
10. Rutkove SB, Caress JB, Cartwright MS, et al. Electrical impedance myography as a biomarker to assess ALS progression. Amyotroph Lateral Scler. 2012; 13:439-445.
11. Spieker AJ, Narayanaswami P, et al. Electrical impedance myography in the diagnosis of radiculopathy. Muscle Nerve 2013;48:800–805.
12. Offit MB, WU T, Floeter MK, Lehky TJ. Electrical impedance myography (EIM in a natural history study of C90RF72 mutation carrriers. Amyotrophic Lateral Scler Frontotemporal Degener. 2020; 21:445-451.
13. Li J, Sung M, et al. Electrophysiologic biomarkers for Assessing Disease Progression and the Effect of Riluzole in SOD1 G93A ALS mice. PLOS ONE. 2013;8:e65976
14. Offit MB, Mohammad, Khanli H, Wu T, Lehky TJ. Electrical impedance myography in healthy volunteers. Muscle Nerve. 2024;69(3):288-294. Doi:10.1002/mus.27978.
15. Sanchez B, Rutkove SB. Electral Impedance Myography and its Applications in Neuromuscular Disorders. Neurotherapeutics. 2017;17:107-118 Doi: 10.1007/s1331-016-0491-x
16. Bertorini Bertorini T, Knickerbocker J, Anwar H, Mays W, Carter K, Metter EJ, Talbot LA. A Case Series Examining Clinic, Laboratory, and Physical Function After Administration of Nusinersen in Adults With Spinal Muscular Atrophy, a Single-Center Study. J Clin Neuromuscul Dis. 2024 Dec 1;26 (2):82-89. doi: 10.1097/CND.0000000000000512. PMID: 39590926.