Small Mobile Stem Cells: A Transformative Paradigm for Regenerative Medicine
Main Article Content
Abstract
Small Mobile Stem cells represent a transformative advance in regenerative medicine. Acting as circulating “smart messaging” cells, they possess the unique ability to sense and respond to tissue-specific environments, orchestrating repair processes dynamically. Through organ-tailored modulation of gene expression programs, SMS cells introduce a novel paradigm of adaptive regeneration, one that transcends traditional models of stem cell differentiation. This approach addresses critical gaps left by conventional stem cell therapies and advanced therapies, offering a more responsive and integrative solution to tissue repair and restoration.
Keywords:
Small Mobile Stem Cells (SMS), Regenerative Medicine, Adaptive Regeneration, Gene Expression Modulation, Tissue Repair
Article Details
How to Cite
RAHMO, Abdulkader.
Small Mobile Stem Cells: A Transformative Paradigm for Regenerative Medicine.
Medical Research Archives, [S.l.], v. 13, n. 10, oct. 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6984>. Date accessed: 06 dec. 2025.
doi: https://doi.org/10.18103/mra.v13i10.6984.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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4. A. Rahmo, R. Schechter. Small Mobile Stem Cells, Unique Regenerative Effects on Lung of Emphysema Animal Model, Currently Undergoing Phase 1 Clinical Trial. Am J Respir Crit Care Med. 2024;209:A6431.
5. Lee MS, Stebbins MJ, Jiao H, Huang HC, Leiferman EM, Walzack BE, et al. Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration. Sci Adv. 2021; 7(21):eabf0907.
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8. Banh L, Cheung KK, Chan MWY, Young EWK, Viswanathan S. Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases. Osteoarthritis Cartilage. 2022;30(7):1050–61.
9. Yang Y, Lin H, Shen H, Wang B, Lei G, Tuan RS. Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo. Acta Biomater. 2018;69:71–82.
10. Paggi CA, Teixeira LM, Le Gac S, Karperien M. Joint-on-chip platforms: entering a new era of in vitro models for arthritis. Nat Rev Rheumatol. 2022;18(4):217–31.
11. Thorp H, Kim K, Kondo M, Grainger DW, Okano T. Fabrication of hyaline-like cartilage constructs using mesenchymal stem cell sheets. Sci Rep. 2020;10(1):20869.
12. Sekiya I, Katano H, Mizuno M, Koga H, Masumoto J, Tomita M, et al. Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees. Sci Rep. 2021;11:13832.
13. Lin W, Wang M, Xu L, Tortorella M, Li G. Cartilage organoids for cartilage development and cartilage-associated disease modeling. Front Cell Dev Biol. 2023;11:1125405.
14. Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, et al. The cellular and physiological basis for lung repair and regeneration: Past, present, and future. Cell Stem Cell. 2020;27(4):482–502.
15. Rock JR, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011;108(52): E1475–83.
16. Zacharias WJ, Frank DB, Zepp JA, Morley MP, Alkhaleel FA, Kong J, et al. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature. 2018;555(7695): 251–5.
17. Somoza RA, Welter JF, Correa D, Caplan AI. Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue Eng Part B Rev. 2014;20(6):596–608.