Potent Antimicrobial properties of a Biodegradable Medical Device in the treatment of Diabetic Foot
Main Article Content
Abstract
There is an urgent need for effective antimicrobial agents to treat infected diabetic foot ulcers (DFUs), which are associated with debilitating symptoms, high rates of amputation, long-term disability, elevated mortality, and significant healthcare costs. This need is even more critical in the era of increasing antimicrobial resistance (AMR). Recent IWGDF/IDSA international guidelines recommend "avoiding antibiotics unless there is confirmed bacterial infection and demonstrated susceptibility to the prescribed agents."
Article Details
How to Cite
GARCÍA, Jorge Cueto et al.
Potent Antimicrobial properties of a Biodegradable Medical Device in the treatment of Diabetic Foot.
Medical Research Archives, [S.l.], v. 13, n. 11, dec. 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/7020>. Date accessed: 26 dec. 2025.
doi: https://doi.org/10.18103/mra.v13i11.7020.
Section
Case Reports
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of diabetes and its burden in the United States. Published November 29, 2023. Accessed June 17, 2025. https://www.cdc.gov/diabetes/data/statistics-report/index.html
2. Swaminathan N, Awuah WA, Bharadwaj HR, et al. Early intervention and care for diabetic foot ulcers in low and middle income countries: addressing challenges and exploring future strategies—a narrative review. Health Sci Rep. 2024;7(5):e2075. doi:10.1002/hsr2.2075
3. Cueto J, Barrientos T, Rodríguez E, Del Moral P. A new biodegradable adhesive for protection of intestinal anastomoses: preliminary communication. Arch Med Res. 2011;42(6):475-481. doi:10.1016/j.arcmed.2011.09.004
4. Cueto J, Moreno M, Bahena Z, et al. Tratamiento de las úlceras venosas varicosas complicadas y refractarias con polímero de maltodextrina y óxido de zinc: reporte inicial. Rev Mex Angiol. 2015;43(3):102-108.
5. Moreno MA, Espinosa-Monroy L, Torres Y, et al. Potent anti-inflammatory activity of carbohydrate polymer with zinc oxide. Biomed Res Int. 2014;2014:712312. doi:10.1155/2014/712312
6. Moreno-Eutimio MA, Espinosa-Monroy L, Orozco-Amaro T, et al. Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results. Arch Med Sci. 2018;14(2):336-344. doi:10.5114/aoms.2016.59851
7. Bello-López JM, López-Ornelas A, Vilchis-Rangel RE, et al. In vitro bactericidal activity of a carbohydrate polymer with zinc oxide for the treatment of chronic wounds. J Med Microbiol. 2020;69(5):874-880. doi:10.1099/jmm.0.001204
8. Cueto J, Ochoa R, Bert E, Tron S, Moreno MA. Chronic venous ulceration in obese patients with diabetes mellitus: a therapeutic challenge. J Diabetol. 2019;3(1):1-6.
9. Cueto J, Ochoa R, Bert E. Multi-traumatized patient with a dehiscent fistulized abdomen and a central venous line-associated infection successfully treated with a new medical device II. Ann Clin Med Case Rep. 2022;9(1):1-3.
10. Suárez D, Franco D, Rey R, Mena T, Cueto J. Successful healing of two very large pelvic-perineal chronic fistulized ulcers in a patient with congenital myelomeningocele treated with a carbohydrate polymer with zinc oxide: case report. J Dermatol Res Rev Rep. 2023;4(2):1-3. doi:10.47363/JDMRS/2023(4)146
11. World Bank. Obesity prevalence, adults (% of adults ages 18+). Gender Data Portal. Accessed June 17, 2025. https://genderdata.worldbank.org/en/indicator/sh-sta-ob18-zs
12. National Institute of Diabetes and Digestive and Kidney Diseases. Overweight & obesity statistics. U.S. Department of Health and Human Services. Accessed June 17, 2025. https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity
13. Jones N, Ray B, Ranjit KT, Manna AC. Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiol Lett. 2008;279(1):71-76. doi:10.1111/j.1574-6968.2007.01056.x
14. Korresteijn J, Driegsman D, Assendelft W, et al. Patient education for preventing diabetic foot ulceration. Cochrane Database Syst Rev. 2010;12:CD001488. doi:10.1002/14651858.CD001488.pub2
15. Infectious Diseases Society of America. Diabetic foot infections. Published October 2, 2023. Accessed June 17, 2025. https://www.idsociety.org/practice-guideline/diabetic-foot-infections/
16. World Health Organization. Antimicrobial resistance. Published November 17, 2023. Accessed June 17, 2025. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
2. Swaminathan N, Awuah WA, Bharadwaj HR, et al. Early intervention and care for diabetic foot ulcers in low and middle income countries: addressing challenges and exploring future strategies—a narrative review. Health Sci Rep. 2024;7(5):e2075. doi:10.1002/hsr2.2075
3. Cueto J, Barrientos T, Rodríguez E, Del Moral P. A new biodegradable adhesive for protection of intestinal anastomoses: preliminary communication. Arch Med Res. 2011;42(6):475-481. doi:10.1016/j.arcmed.2011.09.004
4. Cueto J, Moreno M, Bahena Z, et al. Tratamiento de las úlceras venosas varicosas complicadas y refractarias con polímero de maltodextrina y óxido de zinc: reporte inicial. Rev Mex Angiol. 2015;43(3):102-108.
5. Moreno MA, Espinosa-Monroy L, Torres Y, et al. Potent anti-inflammatory activity of carbohydrate polymer with zinc oxide. Biomed Res Int. 2014;2014:712312. doi:10.1155/2014/712312
6. Moreno-Eutimio MA, Espinosa-Monroy L, Orozco-Amaro T, et al. Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results. Arch Med Sci. 2018;14(2):336-344. doi:10.5114/aoms.2016.59851
7. Bello-López JM, López-Ornelas A, Vilchis-Rangel RE, et al. In vitro bactericidal activity of a carbohydrate polymer with zinc oxide for the treatment of chronic wounds. J Med Microbiol. 2020;69(5):874-880. doi:10.1099/jmm.0.001204
8. Cueto J, Ochoa R, Bert E, Tron S, Moreno MA. Chronic venous ulceration in obese patients with diabetes mellitus: a therapeutic challenge. J Diabetol. 2019;3(1):1-6.
9. Cueto J, Ochoa R, Bert E. Multi-traumatized patient with a dehiscent fistulized abdomen and a central venous line-associated infection successfully treated with a new medical device II. Ann Clin Med Case Rep. 2022;9(1):1-3.
10. Suárez D, Franco D, Rey R, Mena T, Cueto J. Successful healing of two very large pelvic-perineal chronic fistulized ulcers in a patient with congenital myelomeningocele treated with a carbohydrate polymer with zinc oxide: case report. J Dermatol Res Rev Rep. 2023;4(2):1-3. doi:10.47363/JDMRS/2023(4)146
11. World Bank. Obesity prevalence, adults (% of adults ages 18+). Gender Data Portal. Accessed June 17, 2025. https://genderdata.worldbank.org/en/indicator/sh-sta-ob18-zs
12. National Institute of Diabetes and Digestive and Kidney Diseases. Overweight & obesity statistics. U.S. Department of Health and Human Services. Accessed June 17, 2025. https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity
13. Jones N, Ray B, Ranjit KT, Manna AC. Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiol Lett. 2008;279(1):71-76. doi:10.1111/j.1574-6968.2007.01056.x
14. Korresteijn J, Driegsman D, Assendelft W, et al. Patient education for preventing diabetic foot ulceration. Cochrane Database Syst Rev. 2010;12:CD001488. doi:10.1002/14651858.CD001488.pub2
15. Infectious Diseases Society of America. Diabetic foot infections. Published October 2, 2023. Accessed June 17, 2025. https://www.idsociety.org/practice-guideline/diabetic-foot-infections/
16. World Health Organization. Antimicrobial resistance. Published November 17, 2023. Accessed June 17, 2025. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance