The Effects of Low-Energy Electromagnetic Radiation (Rifetech®Plasma) in Patients with Fatigue – An Observational Study
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Abstract
Fatigue is a debilitating condition, often consequent on infections that persist. There are few treatment options, and patients frequently seek complementary medical treatment. One such treatment, a low-energy electromagnetic radiation emitted by RIFETECH®-Plasma, was used in this observational study. The device emits low frequency, low energy radiation modulated onto cold plasma. The frequency can be adapted according to therapeutic specifications.
One hundred and thirteen patients with chronic fatigue were enrolled by 11 practitioners and treated for four weeks, with, on average, two sessions per week which lasted for two hours (median). Outcome was measured with the German version of the Fatigue Severity Scale (FSS) and the World Health Organization 5 Item Quality of Life Questionnaire (WHO-Quol-5) before and after treatment. Since this was a pilot-observational study, the protocol stipulated mainly a descriptive analysis reporting standardized mean differnces, with orienting significance testing by robust non-parametric methods.
The patients were initially severely fatigued (duration of fatigue 20.9 months on average; FFS sum: 50.05 ± 11.4 standard deviation (SD); mean: 5.57 ± 1,27 SD [healthy controls: 3.0; multiple sclerosis patients: 4.66]) and improved after treatment significantly. Improvement was 13.8 points (SD ±13.0) on the FSS and 8.57 (SD ± 8.4) on the WHO-Quol-5 scale (standardized mean difference ≈ 1.0).
We conclude that treatment with individually adapted low-energy, low-frequency EM radiation using RIFETECH-Plasma® is a promising treatment option which should be studied further in controlled trials.
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References
2. Davies K, Dures E, Ng W-F. Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research. Nature Reviews Rheumatology. 2021;17(11):651-664.
3. Smith AP. Twenty-five years of research on the behavioural malaise associated with influenza and the common cold. Psychoneuroendocrinology. 2013;38(6):744-751.
4. Petersen I, Thomas JM, Hamilton WT, White PD. Risk and predictors of fatigue after infectious mononucleosis in a large primary-care cohort. Quarterly Journal of Medicine. 2006;99(1):49-55.
5. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Scientific Reports. 2021;11(1):16144.
6. David A, Hausner D, Frenkel M. Cancer-Related Fatigue—Is There a Role for Complementary and Integrative Medicine? Current Oncology Reports. 2021;23(12):145.
7. Billones R, Liwang JK, Butler K, Graves L, Saligan LN. Dissecting the fatigue experience: A scoping review of fatigue definitions, dimensions, and measures in non-oncologic medical conditions. Brain, Behavior, & Immunity - Health. 2021;15:100266.
8. Kuppuswamy A. The Neurobiology of Pathological Fatigue: New Models, New Questions. The Neuroscientist. 2022;28(3):238-253.
9. Goërtz YMJ, Braamse AMJ, Spruit MA, et al. Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study. Scientific Reports. 2021;11(1):20977.
10. Stephan Y, Sutin AR, Luchetti M, Canada B, Terracciano A. Personality and fatigue: meta-analysis of seven prospective studies. Scientific Reports. 2022;12(1):9156.
11. Walach H, Bösch H, Lewith G, et al. Efficacy of distant healing in patients with chronic fatigue syndrome: A randomised controlled partially blinded trial (EUHEALS) Psychotherapy and Psychosomatics. 2008;77:158-166.
12. Güthlin C, Anton A, Kruse J, Walach H. Subjective concepts of chronically ill patients using distant healing. Qualitative Health Research. 2012; 22:320-331.
13. Nelson MJ, Bahl JS, Buckley JD, Thomson RL, Davison K. Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis. Medicine. 2019;98(43).
14. Hyland ME. Extended network learning error: A new way of conceptualising chronic fatigue syndrome. Psychology and Health. 2001;16:273-287.
15. Hyland ME. The Origins of Health and Disease. Cambridge: Cambridge University Press; 2011.
16. Bazelmans E, Prins J, Lulofs R, van der Meer J, Bleijenberg G. Cognitive Behaviour Group Therapy for Chronic Fatigue Syndrome: A Non-Randomised Waiting List Controlled Study. Psychotherapy and Psychosomatics. 2005;74(4):218-224.
17. Greeson JM, Rosenzweig S, Halbert SC, Cantor IS, Keener MT, Brainard GC. Integrative Medicine Research at an Academic Medical Center: Patient Characteristics and Health-Related Quality-of-Life Outcomes. The Journal of Alternative and Complementary Medicine. 2008;14(6):763-767.
18. Schmieke M. Quantum entangled Frequencies to promote Coherence in Bioenergetic Systems. Dev Sanskriti Interdisciplinary International Journal. 2021;18:10-33.
19. Walach H, Marmann P. Bioenergy Treatment for Improving Well-Being – A Meta-Analysis. Complementary Medical Research. 2023;30(3): 258-269.
20. Walach H, Marmann P. Self-treatment to improve mental and physical health using two bioenergetic devices: A randomized controlled trial. Journal of Psychiatry and Psychiatric Disorders. 2021;5(4):107-119.
21. Lynes B. The Cancer Cure That Worked! Fifty Years of Suppression. Lake Tahoe: Biomed Publishing; 2011, orig. 1987.
22. Fröhlich H, Kremer F. Coherent Excitation in Biological Systems. Berlin: Springer; 1983.
23. Black N. Why we need observational studies to evaluate the effectiveness of health care. British Medical Journal. 1996;312:1215-1218.
24. Valko PO, Bassetti CL, Bloch KE, Held U, Baumann CR. Validation of the Fatigue Severity Scale in a Swiss Cohort. Sleep. 2008;31(11):1601-1607.
25. Sischka PE, Costa AP, Steffgen G, Schmidt AF. The WHO-5 well-being index – validation based on item response theory and the analysis of measurement invariance across 35 countries. Journal of Affective Disorders Reports. 2020;1:100020.
26. Topp CW, Østergaard SD, Søndergaard S, Bech P. The WHO-5 Well-Being Index: A Systematic Review of the Literature. Psychotherapy and Psychosomatics. 2015;84(3):167-176.
27. World Health Organisation. Mental health - a state of well-being Geneva: World Health Organization; 2014.
28. Lewith G, Jonas WB, Walach H, eds. Clinical Research in Complementary Medicine: Principles, Problems Solutions. 2nd revised edition ed. Edinburgh, London: Churchill Livingstone; 2010.
29. Walach H. Placebo effects in Complementary and Alternative Medicine: The selfhealing response. In: Colloca L, Flaten MA, Meissner K, eds. Placbo and Pain: From Bench to Bedside. Amsterdam: Elsevier-Academic Press; 2013:189-202.
30. von Wernsdorff M, Loef M, Tuschen-Caffier B, Schmidt S. Effects of open-label placebos in clinical trials: a systematic review and meta-analysis. Scientific Reports. 2021;11(1):3855.
31. Walach H, Sadaghiani C, Dehm C, Bierman DJ. The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials - A secondary analysis. BMC Medical Research Methodology. 2005;5:26.
32. Walach H, Loef M. Using a matrix-analytical approach to synthesizing evidence solved incompatibility problem in the hierarchy of evidence. Journal of Clinical Epidemiology. 2015;68:1251-1260.
33. European Centre for Disease Prevention and Control. Antimicrobial Resistance Surveillance in Europe 2016. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC;2017.
34. Hansen G. Antibiotic resistance. In: Halabi SF, Gostin LO, Crowley JS, eds. Global Management of Infectious Disease after Ebola. Oxford: Oxford UP; 2017:87-97.
35. Walach H. Complementary Medicine: A Serious Option as We Are Facing the Problem of Bacterial Antibiotic Resistance. Complementary Medicine Research. 2017;24(3):132-134.