The Oncoming Hydrogen Era and The New Paradigm of Cancer and Neurodegenerative Diseases Based on the Hydrogen Ion Dynamics on Cellular Homeostasis and Metabolism - from Etiopathogenesis to Treatment
Main Article Content
Abstract
This brief review addresses cancer and human neurodegenerative diseases (HNDDs) from a unified perspective, entirely different from that of current medicine, oncology, neurology, and neuro-oncology. It is based on the classical concepts of homeostasis and allostasis of Walter Cannon and Hans Selye, as well as the extraordinary discoveries of Otto Warburg in the field of cancer biochemistry. Drawing on numerous publications from our group and thousands of other recent high-impact publications, the main objective of this article is to summarize and update what is already known as "The New Anticancer Paradigm." Recently, this perspective on cancer, centered on altered pH, or H+ dynamics as underlying all the various cancer stages from initiation to metastasis to therapy, has been broadened to include the study of etiology, pathogenesis, and treatment of HNDDs under the same comprehensive and unified approach. At the same time, another positive effect of this conceptualization is to introduce and inaugurate the novel interdisciplinary concept of “The Approaching Hydrogen Age” or “A New Hydrogen Era”.
Keywords:
pH abnormalities in cancer etiology, Warburg effect today, Distinctive features of cancer, Therapeutic implications of pH-dependent homeostasis and allostasis, New anticancer paradigm
Article Details
How to Cite
HARGUINDEY, Salvador et al.
The Oncoming Hydrogen Era and The New Paradigm of Cancer and Neurodegenerative Diseases Based on the Hydrogen Ion Dynamics on Cellular Homeostasis and Metabolism - from Etiopathogenesis to Treatment.
Medical Research Archives, [S.l.], v. 14, n. 1, feb. 2026.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/7161>. Date accessed: 15 feb. 2026.
doi: https://doi.org/10.18103/mra.v14i1.7161.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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