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01 · ABSTRACT

Abstract

This brief review addresses cancer and human neurodegenerative diseases (HNDDs) from a unified perspective, entirely different from that of current medicine, oncology, neurology, and neuro-oncology. It is based on the classical concepts of homeostasis and allostasis of Walter Cannon and Hans Selye, as well as the extraordinary discoveries of Otto Warburg in the field of cancer biochemistry. Drawing on numerous publications from our group and thousands of other recent high-impact publications, the main objective of this article is to summarize and update what is already known as "The New Anticancer Paradigm." Recently, this perspective on cancer, centered on altered pH, or H+ dynamics as underlying all the various cancer stages from initiation to metastasis to therapy, has been broadened to include the study of etiology, pathogenesis, and treatment of HNDDs under the same comprehensive and unified approach. At the same time, another positive effect of this conceptualization is to introduce and inaugurate the novel interdisciplinary concept of “The Approaching Hydrogen Age” or “A New Hydrogen Era”.

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02 · PUBLICATION RECORD

Article details

JournalMedical Research Archives
IssueVol 14 No 1 (2026): Vol.14, Issue 1, January 2026
SectionReview Articles
Published06 February 2026
DOI10.18103/mra.v14i1.7161
ISSN2375-1924
03 · RIGHTS & REUSE

Rights & reuse

This article is published under a Creative Commons Attribution License (CC BY 3.0) and may be shared or distributed by anyone as long as attribution is given to the journal.

Authors & affiliations

SH

Salvador Harguindey, MD, PhD

Institute of Clinical Biology and Metabolism, 01004 Vitoria, Spain.

SR

Stephan J. Reshkin, PhD

Department of Bioscience, Biotechnology and Environment, University of Bari Aldo Moro, 70125, Bari, Italy. 0039 080 544 3385.

JD

Jesús Devesa, MD, PhD

Foltra Medical Center, Teo, La Coruña, Spain.

JO

Julián Polo Orozco, PhD

Institute of Clinical Biology and Metabolism, 01004 Vitoria, Spain.

JA

Jose Luis Arranz, MD, PhD

University of Beira Interior, Covilha, Portugal.

KA

Khalid O. Alfarouk, PhD

Zamzam University College, Khartoum, Sudan and Alfarouk Biomedical Research LLC, Valdosta, GA, USA 31602.

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