Role of the Primate Perirhinal Cortex in Memory and Emotional Regulation: Ontogeny and Early Insults
Main Article Content
Abstract
The perirhinal cortex, a small strip of the anterior medial temporal cortex, first came into prominence through studies of memory. While examining patients with damage to the medial temporal lobe as well as animals with similar regional damage, findings showed that combined damage to the hippocampus, amygdala, and adjacent cortical areas, including the perirhinal cortex, were responsible for the profound memory loss observed. Later, however, the evidence demonstrated that the accompanying damage to the underlying medial temporal cortical areas were largely responsible for the memory deficit that had been attributed to the combined hippocampal and amygdala lesions. The perirhinal cortex has become appreciated as a critical structure supporting familiarity judgement, recognition memory, flexible executive control and behavioral regulation. The objective of this article is first to review the anatomy of the perirhinal cortex and its interactions with other medial temporal structures as well as the neocortex. A series of neurosurgical ablation studies in nonhuman primates will provide evidence for its role in memory and behavioral regulation in adulthood. The next section will highlight the functional maturation of the perirhinal from infancy through adulthood and will show that its role in support of recognition memory emerges in early infancy. The findings will also show that the neonatal perirhinal dysfunction results in functional compensation of recognition and working memory in adulthood but impacts higher-order executive processes such as cognitive control and flexibility. Interestingly, the discovery of the role of perirhinal cortex in familiarity judgements instead of recollection, which is mediated by the hippocampus, is now well documented in several clinical neurodevelopmental disorders (epilepsy, Alzheimer’s disease, schizophrenia), providing valuable markers in the prodromal phase of the diseases for early diagnosis and treatment.
Keywords:
Medial temporal lobe, recognition memory, working memory, executive functions, epilepsy, Alzheimer’s disease, schizophrenia
Article Details
How to Cite
BACHEVALIER, Jocelyne; WEISS, Alison R.
Role of the Primate Perirhinal Cortex in Memory and Emotional Regulation: Ontogeny and Early Insults.
Medical Research Archives, [S.l.], v. 14, n. 2, feb. 2026.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/7272>. Date accessed: 02 mar. 2026.
doi: https://doi.org/10.18103/mra.v14i2.7272.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Milner B. The medial temporal-lobe amnesic syndrome. Psychiatr Clin North Am. 2005;28(3):599-611, 09. doi: 10.1016/j.psc.2005.06.002. PubMed PMID: 16122569.
2. Warrington EK, Weiskrantz L. Organisational aspects of memory in amnesic patients. Neuropsychologia. 1971;9(1):67-73. doi: 10.1016/0028-3932(71)90063-7. PubMed PMID: 5146487.
3. Squire LR. Declarative and Nondeclarative Memory: Multiple Brain Systems Supporting Learning and Memory. Memory Systems 1994: The MIT Press; 1994. p. 203-31.
4. Malamut BL, Saunders RC, Mishkin M. Monkeys with combined amygdalo-hippocampal lesions succeed in object discrimination learning despite 24-hour intertrial intervals. Behav Neurosci. 1984;98(5):759-69. doi: 10.1037//0735-7044.98.5.759. PubMed PMID: 6487412.
5. Meunier M, Bachevalier J, Mishkin M, Murray EA. Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. J Neurosci. 1993;13(12):5418-32. doi: 10.1523/JNEUROSCI.13-12-05418.1993. PubMed PMID: 8254384; PMCID: PMC6576426.
6. Meunier M, Hadfield W, Bachevalier J, Murray EA. Effects of rhinal cortex lesions combined with hippocampectomy on visual recognition memory in rhesus monkeys. J Neurophysiol. 1996;75(3):1190-205. doi: 10.1152/jn.1996.75.3.1190. PubMed PMID: 8867128.
7. Baxter MG, Murray EA. Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys. Hippocampus. 2001;11(1):61-71. doi: 10.1002/1098-1063(2001)11:1<61::AID-HIPO1021>3.0.CO;2-Z. PubMed PMID: 11261774.
8. Heuer E, Bachevalier J. Effects of selective neonatal hippocampal lesions on tests of object and spatial recognition memory in monkeys. Behav Neurosci. 2011;125(2):137-49. doi: 10.1037/a0022539. PubMed PMID: 21341885; PMCID: PMC3072249.
9. Murray EA, Mishkin M. Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and hippocampus. J Neurosci. 1998;18(16):6568-82. doi: 10.1523/JNEUROSCI.18-16-06568.1998. PubMed PMID: 9698344; PMCID: PMC6793180.
10. Beason-Held LL, Rosene DL, Killiany RJ, Moss MB. Hippocampal formation lesions produce memory impairment in the rhesus monkey. Hippocampus. 1999;9(5):562-74. doi: 10.1002/(SICI)1098-1063(1999)9:5<562::AID-HIPO10>3.0.CO;2-X. PubMed PMID: 10560927.
11. Zola SM, Squire LR, Teng E, Stefanacci L, Buffalo EA, Clark RE. Impaired recognition memory in monkeys after damage limited to the hippocampal region. J Neurosci. 2000;20(1):451-63. doi: 10.1523/JNEUROSCI.20-01-00451.2000. PubMed PMID: 10627621; PMCID: PMC6774137.
12. Murray EA. Quality Controls: The Role of Self‐Corrective Science in Explorations of Primate Memory Systems. Hippocampus. 2024;35(1). doi: 10.1002/hipo.23667.
13. Brodmann K. Vergleichende lokalisationslehre der grobhirnrinde. Vergleichende lokalisationslehre der grobhirnrinde1909. p. 324-.
14. Suzuki WA, Amaral DG. Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices. The Journal of Neuroscience. 1994;14(3):1856-77. doi: 10.1523/jneurosci.14-03-01856.1994.
15. Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents. J Comp Neurol. 1994;350(4):497-533. doi: 10.1002/cne.903500402. PubMed PMID: 7890828.
16. Suzuki WA. The anatomy, physiology and functions of the perirhinal cortex. Curr Opin Neurobiol. 1996;6(2):179-86. doi: 10.1016/s0959-4388(96)80071-7. PubMed PMID: 8725959.
17. Ding SL, Van Hoesen GW. Borders, extent, and topography of human perirhinal cortex as revealed using multiple modern neuroanatomical and pathological markers. Human Brain Mapping. 2010;31(9):1359-79. doi: 10.1002/hbm.20940.
18. Miyashita Y. Perirhinal circuits for memory processing. Nat Rev Neurosci. 2019;20(10):577-92. Epub 20190904. doi: 10.1038/s41583-019-0213-6. PubMed PMID: 31485007.
19. Lavenex P, Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: projections to the neocortex. J Comp Neurol. 2002;447(4):394-420. doi: 10.1002/cne.10243. PubMed PMID: 11992524.
20. Insausti R, Amaral DG, Cowan WM. The entorhinal cortex of the monkey: II. Cortical afferents. J Comp Neurol. 1987;264(3):356-95. doi: 10.1002/cne.902640306. PubMed PMID: 2445796.
21. Amaral DG, Price JL. Amygdalo‐cortical projections in the monkey (Macaca fascicularis). Journal of Comparative Neurology. 2004;230(4):465-96. doi: 10.1002/cne.902300402.
22. Kondo H, Saleem KS, Price JL. Differential connections of the perirhinal and parahippocampal cortex with the orbital and medial prefrontal networks in macaque monkeys. J Comp Neurol. 2005;493(4):479-509. doi: 10.1002/cne.20796. PubMed PMID: 16304624.
23. Aggleton JP. Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function. Neuroscience & Biobehavioral Reviews. 2012;36(7):1579-96. doi: 10.1016/j.neubiorev.2011.09.005.
24. Saunders RC, Mishkin M, Aggleton JP. Projections from the entorhinal cortex, perirhinal cortex, presubiculum, and parasubiculum to the medial thalamus in macaque monkeys: identifying different pathways using disconnection techniques. Exp Brain Res. 2005;167(1):1-16. Epub 20051029. doi: 10.1007/s00221-005-2361-3. PubMed PMID: 16143859.
25. Baizer JS, Ungerleider LG, Desimone R. Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques. J Neurosci. 1991;11(1):168-90. doi: 10.1523/JNEUROSCI.11-01-00168.1991. PubMed PMID: 1702462; PMCID: PMC6575184.
26. Desimone R, Schein SJ, Moran J, Ungerleider LG. Contour, color and shape analysis beyond the striate cortex. Vision Res. 1985;25(3):441-52. doi: 10.1016/0042-6989(85)90069-0. PubMed PMID: 4024463.
27. Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc Natl Acad Sci U S A. 1991;88(5):1621-5. doi: 10.1073/pnas.88.5.1621. PubMed PMID: 2000370; PMCID: PMC51076.
28. Mishkin M, Ungerleider LG. Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behav Brain Res. 1982;6(1):57-77. doi: 10.1016/0166-4328(82)90081-x. PubMed PMID: 7126325.
29. Ungerleider LG, Haxby JV. ‘What’ and ‘where’ in the human brain. Current Opinion in Neurobiology. 1994;4(2):157-65. doi: 10.1016/0959-4388(94)90066-3.
30. Wilson HR, Wilkinson F. From orientations to objects: Configural processing in the ventral stream. J Vis. 2015;15(7):4. doi: 10.1167/15.7.4. PubMed PMID: 26024513.
31. Murray EA, Wise SP. Why is there a special issue on perirhinal cortex in a journal called hippocampus? The perirhinal cortex in historical perspective. Hippocampus. 2012;22(10):1941-51. doi: 10.1002/hipo.22055.
32. Murray EA, Richmond BJ. Role of perirhinal cortex in object perception, memory, and associations. Curr Opin Neurobiol. 2001;11(2):188-93. doi: 10.1016/s0959-4388(00)00195-1. PubMed PMID: 11301238.
33. Devlin JT, Price CJ. Perirhinal contributions to human visual perception. Curr Biol. 2007;17(17):1484-8. doi: 10.1016/j.cub.2007.07.066. PubMed PMID: 17764947; PMCID: PMC1971135.
34. Peterson MA, Cacciamani L, Barense MD, Scalf PE. The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity. Hippocampus. 2012;22(10):1965-77. doi: 10.1002/hipo.22065.
35. Barense MD, Ngo JKW, Hung LHT, Peterson MA. Interactions of Memory and Perception in Amnesia: The Figure–Ground Perspective. Cerebral Cortex. 2012;22(11):2680-91. doi: 10.1093/cercor/bhr347.
36. Bussey TJ, Saksida LM, Murray EA. Perirhinal cortex resolves feature ambiguity in complex visual discriminations. Eur J Neurosci. 2002;15(2):365-74. doi: 10.1046/j.0953-816x.2001.01851.x. PubMed PMID: 11849302.
37. Bussey TJ, Saksida LM, Murray EA. Impairments in visual discrimination after perirhinal cortex lesions: testing ‘declarative’ vs. ‘perceptual‐mnemonic’ views of perirhinal cortex function. European Journal of Neuroscience. 2003;17(3):649-60. doi: 10.1046/j.1460-9568.2003.02475.x.
38. Bussey TJ, Saksida LM, Murray EA. The Perceptual-Mnemonic/Feature Conjunction Model of Perirhinal Cortex Function. The Quarterly Journal of Experimental Psychology Section B. 2005;58(3-4b):269-82. doi: 10.1080/02724990544000004.
39. Bussey TJ, Saksida LM, Murray EA. Perirhinal cortex and feature-ambiguous discriminations. Learn Mem. 2006;13(2):103-5; author reply 6-7. doi: 10.1101/lm.163606. PubMed PMID: 16585785.
40. Hales JB, Broadbent NJ, Velu PD, Squire LR, Clark RE. Hippocampus, perirhinal cortex, and complex visual discriminations in rats and humans. Learn Mem. 2015;22(2):83-91. Epub 20150115. doi: 10.1101/lm.035840.114. PubMed PMID: 25593294; PMCID: PMC4341362.
41. Malkova L, Bachevalier J, Webster M, Mishkin M. Effects of neonatal inferior prefrontal and medial temporal lesions on learning the rule for delayed nonmatching-to-sample. Dev Neuropsychol. 2000;18(3):399-421. doi: 10.1207/S1532694207Malkova. PubMed PMID: 11385832.
42. Mumby DG, Pinel JP. Rhinal cortex lesions and object recognition in rats. Behav Neurosci. 1994;108(1):11-8. doi: 10.1037//0735-7044.108.1.11. PubMed PMID: 8192836.
43. Nemanic S, Alvarado MC, Bachevalier J. The Hippocampal/Parahippocampal Regions and Recognition Memory: Insights from Visual Paired Comparison versus Object-Delayed Nonmatching in Monkeys. The Journal of Neuroscience. 2004;24(8):2013-26. doi: 10.1523/jneurosci.3763-03.2004.
44. Wan H, Aggleton JP, Brown MW. Different contributions of the hippocampus and perirhinal cortex to recognition memory. J Neurosci. 1999;19(3):1142-8. doi: 10.1523/JNEUROSCI.19-03-01142.1999. PubMed PMID: 9920675; PMCID: PMC6782155.
45. Bowles B, Crupi C, Mirsattari SM, Pigott SE, Parrent AG, Pruessner JC, Yonelinas AP, Köhler S. Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus. Proceedings of the National Academy of Sciences. 2007;104(41):16382-7. doi: 10.1073/pnas.0705273104.
46. Schoemaker D, Gauthier S, Pruessner JC. Recollection and Familiarity in Aging Individuals with Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review. Neuropsychology Review. 2014;24(3):313-31. doi: 10.1007/s11065-014-9265-6.
47. Yonelinas AP, Kroll NE, Quamme JR, Lazzara MM, Sauve MJ, Widaman KF, Knight RT. Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity. Nat Neurosci. 2002;5(11):1236-41. doi: 10.1038/nn961. PubMed PMID: 12379865.
48. Mayes AR, Holdstock JS, Isaac CL, Montaldi D, Grigor J, Gummer A, Cariga P, Downes JJ, Tsivilis D, Gaffan D, Gong Q, Norman KA. Associative recognition in a patient with selective hippocampal lesions and relatively normal item recognition. Hippocampus. 2004;14(6):763-84. doi: 10.1002/hipo.10211. PubMed PMID: 15318334.
49. Aggleton J, Kyd R, Bilkey D. When is the perirhinal cortex necessary for the performance of spatial memory tasks? Neuroscience & Biobehavioral Reviews. 2004;28(6):611-24. doi: 10.1016/j.neubiorev.2004.08.007.
50. Staresina BP, Fell J, Do Lam AT, Axmacher N, Henson RN. Memory signals are temporally dissociated in and across human hippocampus and perirhinal cortex. Nat Neurosci. 2012;15(8):1167-73. Epub 20120701. doi: 10.1038/nn.3154. PubMed PMID: 22751037; PMCID: PMC3428860.
51. Staresina BP, Fell J, Dunn JC, Axmacher N, Henson RN. Using state-trace analysis to dissociate the functions of the human hippocampus and perirhinal cortex in recognition memory. Proc Natl Acad Sci U S A. 2013;110(8):3119-24. Epub 20130204. doi: 10.1073/pnas.1215710110. PubMed PMID: 23382181; PMCID: PMC3581882.
52. Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA. Remembering episodes: a selective role for the hippocampus during retrieval. Nat Neurosci. 2000;3(11):1149-52. doi: 10.1038/80671. PubMed PMID: 11036273.
53. Vilberg KL, Rugg MD. Dissociation of the neural correlates of recognition memory according to familiarity, recollection, and amount of recollected information. Neuropsychologia. 2007;45(10):2216-25. Epub 20070312. doi: 10.1016/j.neuropsychologia.2007.02.027. PubMed PMID: 17449068; PMCID: PMC1933497.
54. Yonelinas AP. Unpacking the Medial Temporal Lobe: Separating Recollection and Familiarity. Hippocampus. 2025;35(5):e70033. doi: 10.1002/hipo.70033. PubMed PMID: 40919742; PMCID: PMC12416122.
55. Cannon TD, Glahn DC, Kim J, Van Erp TG, Karlsgodt K, Cohen MS, Nuechterlein KH, Bava S, Shirinyan D. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005;62(10):1071-80. doi: 10.1001/archpsyc.62.10.1071. PubMed PMID: 16203952.
56. D'Esposito M, Postle BR, Ballard D, Lease J. Maintenance versus Manipulation of Information Held in Working Memory: An Event-Related fMRI Study. Brain and Cognition. 1999;41(1):66-86. doi: 10.1006/brcg.1999.1096.
57. Glahn DC, Kim J, Cohen MS, Poutanen VP, Therman S, Bava S, Van Erp TG, Manninen M, Huttunen M, Lonnqvist J, Standertskjold-Nordenstam CG, Cannon TD. Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage. 2002;17(1):201-13. doi: 10.1006/nimg.2002.1161. PubMed PMID: 12482077.
58. Petrides M. Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey. J Neurosci. 1995;15(1 Pt 1):359-75. doi: 10.1523/JNEUROSCI.15-01-00359.1995. PubMed PMID: 7823141; PMCID: PMC6578311.
59. Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SPMJ, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD. Redefining the functional organization of working memory processes within human lateral prefrontal cortex. European Journal of Neuroscience. 1999;11(2):567-74. doi: 10.1046/j.1460-9568.1999.00449.x.
60. Petrides M. Monitoring of selections of visual stimuli and the primate frontal cortex. Proc Biol Sci. 1991;246(1317):293-8. doi: 10.1098/rspb.1991.0157. PubMed PMID: 1686095.
61. Petrides M. Functional specialization within the dorsolateral frontal cortex for serial order memory. Proc Biol Sci. 1991;246(1317):299-306. doi: 10.1098/rspb.1991.0158. PubMed PMID: 1686096.
62. Kowalska DM, Bachevalier J, Mishkin M. The role of the inferior prefrontal convexity in performance of delayed nonmatching-to-sample. Neuropsychologia. 1991;29(6):583-600. doi: 10.1016/0028-3932(91)90012-w. PubMed PMID: 1944863.
63. Miller EK, Buschman TJ. Cortical circuits for the control of attention. Curr Opin Neurobiol. 2013;23(2):216-22. Epub 20121222. doi: 10.1016/j.conb.2012.11.011. PubMed PMID: 23265963; PMCID: PMC3709832.
64. Mishkin M, Manning FJ. Non-spatial memory after selective prefrontal lesions in monkeys. Brain Res. 1978;143(2):313-23. doi: 10.1016/0006-8993(78)90571-1. PubMed PMID: 415803.
65. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24(1):167-202. doi: 10.1146/annurev.neuro.24.1.167. PubMed PMID: 11283309.
66. Passingham R. Delayed matching after selective prefrontal lesions in monkeys (Macaca mulatta). Brain Res. 1975;92(1):89-102. doi: 10.1016/0006-8993(75)90529-6. PubMed PMID: 809096.
67. Constantinidis C, Procyk E. The primate working memory networks. Cogn Affect Behav Neurosci. 2004;4(4):444-65. doi: 10.3758/cabn.4.4.444. PubMed PMID: 15849890; PMCID: PMC3885185.
68. Davachi L, Goldman-Rakic PS. Primate Rhinal Cortex Participates in Both Visual Recognition and Working Memory Tasks: Functional Mapping With 2-DG. Journal of Neurophysiology. 2001;85(6):2590-601. doi: 10.1152/jn.2001.85.6.2590.
69. Kimble DP, Pribram KH. Hippocampectomy and behavior sequences. Science. 1963;139(3557):824-5. doi: 10.1126/science.139.3557.824. PubMed PMID: 14032718.
70. Libby LA, Ekstrom AD, Ragland JD, Ranganath C. Differential Connectivity of Perirhinal and Parahippocampal Cortices within Human Hippocampal Subregions Revealed by High-Resolution Functional Imaging. The Journal of Neuroscience. 2012;32(19):6550-60. doi: 10.1523/jneurosci.3711-11.2012.
71. Petrides M. The role of the mid-dorsolateral prefrontal cortex in working memory. Executive Control and the Frontal Lobe: Current Issues: Springer Berlin Heidelberg; 2000. p. 44-54.
72. Ranganath C, Cohen MX, Dam C, D'Esposito M. Inferior temporal, prefrontal, and hippocampal contributions to visual working memory maintenance and associative memory retrieval. J Neurosci. 2004;24(16):3917-25. doi: 10.1523/JNEUROSCI.5053-03.2004. PubMed PMID: 15102907; PMCID: PMC6729418.
73. Stern CE, Sherman SJ, Kirchhoff BA, Hasselmo ME. Medial temporal and prefrontal contributions to working memory tasks with novel and familiar stimuli. Hippocampus. 2001;11(4):337-46. doi: 10.1002/hipo.1048. PubMed PMID: 11530838.
74. Lehky SR, Tanaka K. Enhancement of object representations in primate perirhinal cortex during a visual working-memory task. J Neurophysiol. 2007;97(2):1298-310. Epub 20061115. doi: 10.1152/jn.00167.2006. PubMed PMID: 17108097.
75. Owen AM, Roberts AC, Hodges JR, Robbins TW. Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease. Brain. 1993;116(5):1159-75. doi: 10.1093/brain/116.5.1159.
76. Postle BR, Brush LN, Nick AM. Prefrontal cortex and the mediation of proactive interference in working memory. Cogn Affect Behav Neurosci. 2004;4(4):600-8. doi: 10.3758/cabn.4.4.600. PubMed PMID: 15849900; PMCID: PMC1201535.
77. Ridderinkhof KR, Span MM, van der Molen MW. Perseverative behavior and adaptive control in older adults: performance monitoring, rule induction, and set shifting. Brain Cogn. 2002;49(3):382-401. doi: 10.1006/brcg.2001.1506. PubMed PMID: 12139960.
78. Jha AP, Fabian SA, Aguirre GK. The role of prefrontal cortex in resolving distractor interference. Cogn Affect Behav Neurosci. 2004;4(4):517-27. doi: 10.3758/cabn.4.4.517. PubMed PMID: 15849894.
79. Monchi O, Petrides M, Petre V, Worsley K, Dagher A. Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imaging. J Neurosci. 2001;21(19):7733-41. doi: 10.1523/JNEUROSCI.21-19-07733.2001. PubMed PMID: 11567063; PMCID: PMC6762921.
80. Collins P, Roberts AC, Dias R, Everitt BJ, Robbins TW. Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex. J Cogn Neurosci. 1998;10(3):332-54. doi: 10.1162/089892998562771. PubMed PMID: 9869708.
81. Petrides M, Milner B. Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia. 1982;20(3):249-62. doi: 10.1016/0028-3932(82)90100-2. PubMed PMID: 7121793.
82. Ross TP, Hanouskova E, Giarla K, Calhoun E, Tucker M. The reliability and validity of the self-ordered pointing task. Arch Clin Neuropsychol. 2007;22(4):449-58. Epub 20070223. doi: 10.1016/j.acn.2007.01.023. PubMed PMID: 17321716.
83. Bissonette GB, Powell EM, Roesch MR. Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex. Behav Brain Res. 2013;250:91-101. Epub 20130509. doi: 10.1016/j.bbr.2013.04.037. PubMed PMID: 23664821; PMCID: PMC3708542.
84. Burnham KE, Bannerman DM, Dawson LA, Southam E, Sharp T, Baxter MG. Fos expression in the brains of rats performing an attentional set-shifting task. Neuroscience. 2010;171(2):485-95. Epub 20100916. doi: 10.1016/j.neuroscience.2010.09.008. PubMed PMID: 20849932; PMCID: PMC2989446.
85. Dias R, Robbins TW, Roberts AC. Dissociable Forms of Inhibitory Control within Prefrontal Cortex with an Analog of the Wisconsin Card Sort Test: Restriction to Novel Situations and Independence from “On-Line” Processing. The Journal of Neuroscience. 1997;17(23):9285-97. doi: 10.1523/jneurosci.17-23-09285.1997.
86. Rogers RD, Andrews TC, Grasby PM, Brooks DJ, Robbins TW. Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci. 2000;12(1):142-62. doi: 10.1162/089892900561931. PubMed PMID: 10769312.
87. Barbas H, Pandya DN. Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol. 1989;286(3):353-75. doi: 10.1002/cne.902860306. PubMed PMID: 2768563.
88. Petrides M, Pandya DN. Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey. Eur J Neurosci. 2002;16(2):291-310. doi: 10.1046/j.1460-9568.2001.02090.x. PubMed PMID: 12169111.
89. Murray EA, Baxter MG, Gaffan D. Monkeys with rhinal cortex damage or neurotoxic hippocampal lesions are impaired on spatial scene learning and object reversals. Behav Neurosci. 1998;112(6):1291-303. doi: 10.1037//0735-7044.112.6.1291. PubMed PMID: 9926813.
90. Hampton RR, Murray EA. Learning of discriminations is impaired, but generalization to altered views is intact, in monkeys (Macaca mulatta) with perirhinal cortex removal. Behav Neurosci. 2002;116(3):363-77. doi: 10.1037//0735-7044.116.3.363. PubMed PMID: 12049317.
91. Owen AM, Roberts AC, Polkey CE, Sahakian BJ, Robbins TW. Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia. 1991;29(10):993-1006. doi: 10.1016/0028-3932(91)90063-e. PubMed PMID: 1762678.
92. Otto T, Cousens G, Herzog C. Behavioral and neuropsychological foundations of olfactory fear conditioning. Behav Brain Res. 2000;110(1-2):119-28. doi: 10.1016/s0166-4328(99)00190-4. PubMed PMID: 10802309.
93. Gray JA, McNaughton N. The Neuropsychology of Anxiety: An Enquiry Into the Function of the Septo-hippocampal System: Oxford University Press; 2003.
94. Paz R, Pelletier JG, Bauer EP, Pare D. Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions. Nat Neurosci. 2006;9(10):1321-9. Epub 20060910. doi: 10.1038/nn1771. PubMed PMID: 16964249.
95. Paz R, Pare D. Physiological basis for emotional modulation of memory circuits by the amygdala. Curr Opin Neurobiol. 2013;23(3):381-6. Epub 20130205. doi: 10.1016/j.conb.2013.01.008. PubMed PMID: 23394774; PMCID: PMC3652906.
96. Paz R, Bauer EP, Pare D. Learning-related facilitation of rhinal interactions by medial prefrontal inputs. J Neurosci. 2007;27(24):6542-51. doi: 10.1523/JNEUROSCI.1077-07.2007. PubMed PMID: 17567815; PMCID: PMC6672438.
97. Meunier M, Bachevalier J. Comparison of emotional responses in monkeys with rhinal cortex or amygdala lesions. Emotion. 2002;2(2):147-61. doi: 10.1037/1528-3542.2.2.147. PubMed PMID: 12899188.
98. Meunier M, Cirilli L, Bachevalier J. Responses to affective stimuli in monkeys with entorhinal or perirhinal cortex lesions. J Neurosci. 2006;26(29):7718-22. doi: 10.1523/JNEUROSCI.1949-06.2006. PubMed PMID: 16855099; PMCID: PMC6674284.
99. Pascalis O, de Schonen S. Recognition memory in 3− to 4-day-old human neonates. NeuroReport. 1994;5(14):1721-4. doi: 10.1097/00001756-199409080-00008.
100. Pascalis O, de Haan M, Nelson CA, de Schonen S. Long-term recognition memory for faces assessed by visual paired comparison in 3- and 6-month-old infants. J Exp Psychol Learn Mem Cogn. 1998;24(1):249-60. doi: 10.1037//0278-7393.24.1.249. PubMed PMID: 9438961.
101. Gunderson VM, Sackett GP. Development of pattern recognition in infant pigtailed macaques (Macaca nemestrina). Developmental Psychology. 1984;20(3):418-26. doi: 10.1037/0012-1649.20.3.418.
102. Zeamer A, Heuer E, Bachevalier J. Developmental Trajectory of Object Recognition Memory in Infant Rhesus Macaques with and without Neonatal Hippocampal Lesions. Journal of Neuroscience. 2010;30(27):9157-65. doi: 10.1523/jneurosci.0022-10.2010.
103. Zeamer A, Richardson RL, Weiss AR, Bachevalier J. The development of object recognition memory in rhesus macaques with neonatal lesions of the perirhinal cortex. Dev Cogn Neurosci. 2015;11:31-41. Epub 20140721. doi: 10.1016/j.dcn.2014.07.002. PubMed PMID: 25096364; PMCID: PMC4302071.
104. Weiss AR, Bachevalier J. Object and spatial memory after neonatal perirhinal lesions in monkeys. Behav Brain Res. 2016;298(Pt B):210-7. Epub 20151123. doi: 10.1016/j.bbr.2015.11.010. PubMed PMID: 26593109; PMCID: PMC4688056.
105. Blue SN, Kazama AM, Bachevalier J. Development of Memory for Spatial Locations and Object/Place Associations in Infant Rhesus Macaques with and without Neonatal Hippocampal Lesions. Journal of the International Neuropsychological Society. 2013;19(10):1053-64. doi: 10.1017/s1355617713000799.
106. Zeamer A, Meunier M, Bachevalier J. Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions. Learn Mem. 2011;18(3):170-80. Epub 20110225. doi: 10.1101/lm.2076811. PubMed PMID: 21357439; PMCID: PMC3056513.
107. Zeamer A, Bachevalier J. Long-term effects of neonatal hippocampal lesions on novelty preference in monkeys. Hippocampus. 2013;23(9):745-50. Epub 20130606. doi: 10.1002/hipo.22139. PubMed PMID: 23640834; PMCID: PMC3775855.
108. Lavenex P. Functional Anatomy, Development, and Pathology of the Hippocampus. The Clinical Neurobiology of the Hippocampus: Oxford University Press; 2012. p. 10-38.
109. Lavenex P, Banta Lavenex P, Amaral DG. Postnatal Development of the Primate Hippocampal Formation. Developmental Neuroscience. 2007;29(1-2):179-92. doi: 10.1159/000096222.
110. Payne C, Machado CJ, Bliwise NG, Bachevalier J. Maturation of the hippocampal formation and amygdala in Macaca mulatta: A volumetric magnetic resonance imaging study. Hippocampus. 2010;20(8):922-35. doi: 10.1002/hipo.20688.
111. Cioni G, D'Acunto G, Guzzetta A. Perinatal brain damage in children: neuroplasticity, early intervention, and molecular mechanisms of recovery. Prog Brain Res. 2011;189:139-54. doi: 10.1016/B978-0-444-53884-0.00022-1. PubMed PMID: 21489387.
112. Goldman PS, Rosvold HE, Mishkin M. Selective sparing of function following prefrontal lobectomy in infant monkeys. Exp Neurol. 1970;29(2):221-6. doi: 10.1016/0014-4886(70)90053-1. PubMed PMID: 4994109.
113. Miller EA, Goldman PS, Rosvold HE. Delayed recovery of function following orbital prefrontal lesions in infant monkeys. Science. 1973;182(4109):304-6. doi: 10.1126/science.182.4109.304. PubMed PMID: 4200506.
114. Kolb B, Gibb R. Brain plasticity and behaviour in the developing brain. J Can Acad Child Adolesc Psychiatry. 2011;20(4):265-76. PubMed PMID: 22114608; PMCID: PMC3222570.
115. Kolb B, Mychasiuk R, Muhammad A, Gibb R. Brain plasticity in the developing brain. Prog Brain Res. 2013;207:35-64. doi: 10.1016/B978-0-444-63327-9.00005-9. PubMed PMID: 24309250.
116. Gaffan D. Dissociated effects of perirhinal cortex ablation, fornix transection and amygdalectomy: evidence for multiple memory systems in the primate temporal lobe. Exp Brain Res. 1994;99(3):411-22. doi: 10.1007/BF00228977. PubMed PMID: 7957720.
117. Aggleton JP, Keen S, Warburton EC, Bussey TJ. Extensive Cytotoxic Lesions Involving Both the Rhinal Cortices and Area TE Impair Recognition But Spare Spatial Alternation in the Rat. Brain Research Bulletin. 1997;43(3):279-87. doi: 10.1016/s0361-9230(97)00007-5.
118. Vann SD, Brown MW, Erichsen JT, Aggleton JP. Fos imaging reveals differential patterns of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests. J Neurosci. 2000;20(7):2711-8. doi: 10.1523/JNEUROSCI.20-07-02711.2000. PubMed PMID: 10729352; PMCID: PMC6772240.
119. Machin P, Vann SD, Muir JL, Aggleton JP. Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory. Behav Neurosci. 2002;116(2):232-40. doi: 10.1037//0735-7044.116.2.232. PubMed PMID: 11996309.
120. Winters BD, Forwood SE, Cowell RA, Saksida LM, Bussey TJ. Double Dissociation between the Effects of Peri-Postrhinal Cortex and Hippocampal Lesions on Tests of Object Recognition and Spatial Memory: Heterogeneity of Function within the Temporal Lobe. The Journal of Neuroscience. 2004;24(26):5901-8. doi: 10.1523/jneurosci.1346-04.2004.
121. Bachevalier J, Nemanic S. Memory for spatial location and object‐place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex. Hippocampus. 2007;18(1):64-80. doi: 10.1002/hipo.20369.
122. Ramos JM. Essential role of the perirhinal cortex in complex tactual discrimination tasks in rats. Cereb Cortex. 2014;24(8):2068-80. Epub 20130228. doi: 10.1093/cercor/bht054. PubMed PMID: 23448873.
123. Wiig KA, Bilkey DK. Perirhinal cortex lesions in rats disrupt performance in a spatial DNMS task. Neuroreport. 1994;5(11):1405-8. doi: 10.1097/00001756-199406000-00029. PubMed PMID: 7919210.
124. Wiig KA, Burwell RD. Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat. Behav Neurosci. 1998;112(4):827-38. doi: 10.1037//0735-7044.112.4.827. PubMed PMID: 9733190.
125. Alvarado MC, Bachevalier J. Comparison of the effects of damage to the perirhinal and parahippocampal cortex on transverse patterning and location memory in rhesus macaques. J Neurosci. 2005;25(6):1599-609. doi: 10.1523/JNEUROSCI.4457-04.2005. PubMed PMID: 15703414; PMCID: PMC6725995.
126. Hampton RR. Monkey perirhinal cortex is critical for visual memory, but not for visual perception: reexamination of the behavioural evidence from monkeys. Q J Exp Psychol B. 2005;58(3-4):283-99. doi: 10.1080/02724990444000195. PubMed PMID: 16194970.
127. Weiss AR, Guo W, Richardson R, Bachevalier J. Intact perceptual ability, but impaired familiarity judgment, after neonatal perirhinal lesions in rhesus macaques. Dev Cogn Neurosci. 2017;28:54-64. Epub 20171031. doi: 10.1016/j.dcn.2017.10.006. PubMed PMID: 29175539; PMCID: PMC5737963.
128. Browning PG, Baxter MG, Gaffan D. Prefrontal-temporal disconnection impairs recognition memory but not familiarity discrimination. J Neurosci. 2013;33(23):9667-74. doi: 10.1523/JNEUROSCI.5759-12.2013. PubMed PMID: 23739963; PMCID: PMC3797511.
129. Kazama AM, Davis M, Bachevalier J. Neonatal lesions of orbital frontal areas 11/13 in monkeys alter goal-directed behavior but spare fear conditioning and safety signal learning. Front Neurosci. 2014;8:37. Epub 20140304. doi: 10.3389/fnins.2014.00037. PubMed PMID: 24624054; PMCID: PMC3940964.
130. Weiss AR, Nadji R, Bachevalier J. Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference. Front Syst Neurosci. 2015;9:179. Epub 20160105. doi: 10.3389/fnsys.2015.00179. PubMed PMID: 26778978; PMCID: PMC4700260.
131. Weiss AR, White J, Richardson R, Bachevalier J. Impaired Cognitive Flexibility After Neonatal Perirhinal Lesions in Rhesus Macaques. Front Syst Neurosci. 2019;13:6. Epub 2019/02/15. doi: 10.3389/fnsys.2019.00006. PubMed PMID: 30760985; PMCID: PMC6363703.
132. Cavada C, Company T, Tejedor J, Cruz-Rizzolo RJ, Reinoso-Suarez F. The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb Cortex. 2000;10(3):220-42. doi: 10.1093/cercor/10.3.220. PubMed PMID: 10731218.
133. Croxson PL, Johansen-Berg H, Behrens TE, Robson MD, Pinsk MA, Gross CG, Richter W, Richter MC, Kastner S, Rushworth MF. Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography. J Neurosci. 2005;25(39):8854-66. doi: 10.1523/JNEUROSCI.1311-05.2005. PubMed PMID: 16192375; PMCID: PMC6725599.
134. Vismer MS, Forcelli PA, Skopin MD, Gale K, Koubeissi MZ. The piriform, perirhinal, and entorhinal cortex in seizure generation. Front Neural Circuits. 2015;9:27. Epub 20150529. doi: 10.3389/fncir.2015.00027. PubMed PMID: 26074779; PMCID: PMC4448038.
135. Curot J, Busigny T, Valton L, Denuelle M, Vignal J-P, Maillard L, Chauvel P, Pariente J, Trebuchon A, Bartolomei F, Barbeau EJ. Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena. Neuroscience & Biobehavioral Reviews. 2017;78:161-77. doi: 10.1016/j.neubiorev.2017.04.018.
136. Bonilha L, Kobayashi E, Rorden C, Cendes F, Li LM. Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2003;74(12):1627-30. doi: 10.1136/jnnp.74.12.1627. PubMed PMID: 14638879; PMCID: PMC1757422.
137. Gloor P. Experiential phenomena of temporal lobe epilepsy. Facts and hypotheses. Brain. 1990;113 ( Pt 6)(6):1673-94. doi: 10.1093/brain/113.6.1673. PubMed PMID: 2276040.
138. Gloor P, Olivier A, Quesney LF, Andermann F, Horowitz S. The role of the limbic system in experiential phenomena of temporal lobe epilepsy. Ann Neurol. 1982;12(2):129-44. doi: 10.1002/ana.410120203. PubMed PMID: 7125603.
139. Jackson JH, Colman WS. Case of Epilepsy with Tasting Movements and “Dreamy State”—Very Small Patch of Softening in the Left Uncinate Gyrus. Brain. 1898;21(4):580-90. doi: 10.1093/brain/21.4.580.
140. Jackson JH, Stewart P. Epileptic Attacks with a Warning of a Crude Sensation of Smell and with the Intellectual Aura (Dreamy State) in a Patient Who Had Symptoms Pointing to Gross Organic Disease of the Right Temporo-Sphenoidal Lobe. Brain. 1899;22(4):534-49. doi: 10.1093/brain/22.4.534.
141. Penfield W. Some Mechanisms of Consciousness Discovered during Electrical Stimulation of the Brain. Proceedings of the National Academy of Sciences. 1958;44(2):51-66. doi: 10.1073/pnas.44.2.51.
142. Vignal JP, Maillard L, McGonigal A, Chauvel P. The dreamy state: hallucinations of autobiographic memory evoked by temporal lobe stimulations and seizures. Brain. 2007;130(Pt 1):88-99. Epub 20061130. doi: 10.1093/brain/awl329. PubMed PMID: 17142246.
143. Bartolomei F, Barbeau E, Gavaret M, Guye M, McGonigal A, Régis J, Chauvel P. Cortical stimulation study of the role of rhinal cortex in déjà vu and reminiscence of memories. Neurology. 2004;63(5):858-64. doi: 10.1212/01.Wnl.0000137037.56916.3f.
144. Guedj E, Aubert S, McGonigal A, Mundler O, Bartolomei F. Déjà-vu in temporal lobe epilepsy: Metabolic pattern of cortical involvement in patients with normal brain MRI. Neuropsychologia. 2010;48(7):2174-81. doi: 10.1016/j.neuropsychologia.2010.04.009.
145. Takeda Y, Kurita T, Sakurai K, Shiga T, Tamaki N, Koyama T. Persistent déjà vu associated with hyperperfusion in the entorhinal cortex. Epilepsy & Behavior. 2011;21(2):196-9. doi: 10.1016/j.yebeh.2011.03.031.
146. Weinand ME, Hermann B, Wyler AR, Carter LP, Oommen KJ, Labiner D, Ahern G, Herring A. Long-term subdural strip electrocorticographic monitoring of ictal deja vu. Epilepsia. 1994;35(5):1054-9. doi: 10.1111/j.1528-1157.1994.tb02554.x. PubMed PMID: 7925151.
147. Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia. 2013;54(12):2048-59. Epub 20131010. doi: 10.1111/epi.12400. PubMed PMID: 24117098; PMCID: PMC4880458.
148. Aggleton JP, Brown MW. Episodic memory, amnesia, and the hippocampal–anterior thalamic axis. Behavioral and Brain Sciences. 1999;22(3):425-44. doi: 10.1017/s0140525x99002034.
149. Eichenbaum H. A cortical–hippocampal system for declarative memory. Nature Reviews Neuroscience. 2000;1(1):41-50. doi: 10.1038/35036213.
150. Squire LR, Wixted JT, Clark RE. Recognition memory and the medial temporal lobe: a new perspective. Nat Rev Neurosci. 2007;8(11):872-83. doi: 10.1038/nrn2154. PubMed PMID: 17948032; PMCID: PMC2323975.
151. Montaldi D, Mayes AR. The role of recollection and familiarity in the functional differentiation of the medial temporal lobes. Hippocampus. 2010;20(11):1291-314. doi: 10.1002/hipo.20853. PubMed PMID: 20928828.
152. Spatt J. Déjà Vu: Possible Parahippocampal Mechanisms. The Journal of Neuropsychiatry and Clinical Neurosciences. 2002;14(1):6-10. doi: 10.1176/jnp.14.1.6.
153. Martin CB, Mirsattari SM, Pruessner JC, Pietrantonio S, Burneo JG, Hayman-Abello B, Köhler S. Déjà vu in unilateral temporal-lobe epilepsy is associated with selective familiarity impairments on experimental tasks of recognition memory. Neuropsychologia. 2012;50(13):2981-91. doi: 10.1016/j.neuropsychologia.2012.07.030.
154. Fernandez G, Tendolkar I. The rhinal cortex: ‘gatekeeper’ of the declarative memory system. Trends in Cognitive Sciences. 2006;10(8):358-62. doi: 10.1016/j.tics.2006.06.003.
155. Suzuki WA, Naya Y. The perirhinal cortex. Annu Rev Neurosci. 2014;37(1):39-53. doi: 10.1146/annurev-neuro-071013-014207. PubMed PMID: 25032492.
156. Long JM, Holtzman DM. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell. 2019;179(2):312-39. Epub 20190926. doi: 10.1016/j.cell.2019.09.001. PubMed PMID: 31564456; PMCID: PMC6778042.
157. Morris JC, Kimberly A, Quaid K, Holtzman DM, Kantarci K, Kaye J, Reiman EM, Klunk WE, Siemers ER. Role of biomarkers in studies of presymptomatic Alzheimer's disease. Alzheimer's & Dementia. 2005;1(2):145-51. doi: 10.1016/j.jalz.2005.09.013.
158. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Jr., Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):280-92. Epub 20110421. doi: 10.1016/j.jalz.2011.03.003. PubMed PMID: 21514248; PMCID: PMC3220946.
159. Giannakopoulos P, Herrmann FR, Bussière T, Bouras C, Kövari E, Perl DP, Morrison JH, Gold G, Hof PR. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease. Neurology. 2003;60(9):1495-500. doi: 10.1212/01.Wnl.0000063311.58879.01.
160. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239-59. doi: 10.1007/BF00308809. PubMed PMID: 1759558.
161. Bobinski M, Wegiel J, Tarnawski M, Bobinski M, Reisberg B, De Leon MJ, Miller DC, Wisniewski HM. Relationships between Regional Neuronal Loss and Neurofibrillary Changes in the Hippocampal Formation and Duration and Severity of Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. 1997;56(4):414-20. doi: 10.1097/00005072-199704000-00010.
162. Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol. 1997;41(1):17-24. doi: 10.1002/ana.410410106. PubMed PMID: 9005861.
163. Suzuki WA. Making new memories: the role of the hippocampus in new associative learning. Ann N Y Acad Sci. 2007;1097(1):1-11. doi: 10.1196/annals.1379.007. PubMed PMID: 17413005.
164. Pihlajamäki M, Soininen H. Alzheimer’s Disease. The Clinical Neurobiology of the Hippocampus: Oxford University Press; 2012. p. 223-44.
165. van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM. Hippocampal atrophy in Alzheimer disease: Age matters. Neurology. 2006;66(2):236-8. doi: 10.1212/01.wnl.0000194240.47892.4d.
166. De Leon M, George A, Stylopoulos L, Smith G, Miller D. Early Marker for Alzheimer's Disease: The Atrophic Hippocampus. The Lancet. 1989;334(8664):672-3. doi: 10.1016/s0140-6736(89)90911-2.
167. De Leon MJ, George AE, Golomb J, Tarshish C, Convit A, Kluger A, De Santi S, Mc Rae T, Ferris SH, Reisberg B, Ince C, Rusinek H, Bobinski M, Quinn B, Miller DC, Wisniewski HM. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiology of Aging. 1997;18(1):1-11. doi: 10.1016/s0197-4580(96)00213-8.
168. de Leon MJ, Smith G, George AE, McRae T, Golomb J, Convit A, Kluger A, Tsui W, Ferris SH, Wolf AP. CT, MRI, and PET Studies of Hippocampal Pathology in Alzheimer’s Disease. Neurodevelopment, Aging and Cognition: Birkhäuser Boston; 1992. p. 323-35.
169. Jack CR, Jr., Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Cha RH, Tangalos EG, Petersen RC. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology. 2004;62(4):591-600. doi: 10.1212/01.wnl.0000110315.26026.ef. PubMed PMID: 14981176; PMCID: PMC2730165.
170. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human Brain Mapping. 2009;30(9):2766-88. doi: 10.1002/hbm.20708.
171. Ridha BH, Anderson VM, Barnes J, Boyes RG, Price SL, Rossor MN, Whitwell JL, Jenkins L, Black RS, Grundman M, Fox NC. Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression. J Neurol. 2008;255(4):567-74. Epub 20080218. doi: 10.1007/s00415-008-0750-9. PubMed PMID: 18274807.
172. Qiu A, Fennema-Notestine C, Dale AM, Miller MI. Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. NeuroImage. 2009;45(3):656-61. doi: 10.1016/j.neuroimage.2009.01.013.
173. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hanninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala EL, Vainio P, Vanninen R, Partanen K, Soininen H. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging. 2004;25(3):303-10. doi: 10.1016/S0197-4580(03)00084-8. PubMed PMID: 15123335.
174. Forsberg A, Engler H, Almkvist O, Blomquist G, Hagman G, Wall A, Ringheim A, Langstrom B, Nordberg A. PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging. 2008;29(10):1456-65. Epub 20070511. doi: 10.1016/j.neurobiolaging.2007.03.029. PubMed PMID: 17499392.
175. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frölich L, Schönknecht P, Ito K, Mielke R, Kalbe E. Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PET. NeuroImage. 2002;17(1):302-16. doi: 10.1006/nimg.2002.1208.
176. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Clerici F, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon MJ. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias. Journal of Nuclear Medicine. 2008;49(3):390-8. doi: 10.2967/jnumed.107.045385.
177. Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, Beckett LA, deToledo-Morrell L. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease ☆ ☆This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health. Neurobiology of Aging. 2001;22(5):747-54. doi: 10.1016/s0197-4580(01)00271-8.
178. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 2002;58(8):1188-96. doi: 10.1212/wnl.58.8.1188. PubMed PMID: 11971085.
179. Henzen NA, Abdulkadir A, Reinhardt J, Blatow M, Kressig RW, Krumm S. Automated segmentation for cortical thickness of the medial perirhinal cortex. Sci Rep. 2025;15(1):14903. Epub 20250428. doi: 10.1038/s41598-025-98399-w. PubMed PMID: 40295570; PMCID: PMC12037834.
180. Rapoport JL, Giedd JN, Gogtay N. Neurodevelopmental model of schizophrenia: update 2012. Mol Psychiatry. 2012;17(12):1228-38. Epub 20120410. doi: 10.1038/mp.2012.23. PubMed PMID: 22488257; PMCID: PMC3504171.
181. Kendler KS. What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. Molecular Psychiatry. 2013;18(10):1058-66. doi: 10.1038/mp.2013.50.
182. Harrison PJ. Recent genetic findings in schizophrenia and their therapeutic relevance. Journal of Psychopharmacology. 2014;29(2):85-96. doi: 10.1177/0269881114553647.
183. Andreasen NC. A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly. Arch Gen Psychiatry. 1999;56(9):781-7. doi: 10.1001/archpsyc.56.9.781. PubMed PMID: 12884883.
184. Karantonis JA, Carruthers SP, Rossell SL, Pantelis C, Hughes M, Wannan C, Cropley V, Van Rheenen TE. A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum. Schizophr Bull. 2021;47(6):1557-600. doi: 10.1093/schbul/sbab054. PubMed PMID: 34097043; PMCID: PMC8530395.
185. Yamazaki R, Matsumoto J, Ito S, Nemoto K, Fukunaga M, Hashimoto N, Kodaka F, Takano H, Hasegawa N, Yasuda Y, Fujimoto M, Yamamori H, Watanabe Y, Miura K, Hashimoto R. Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function. Neuropsychopharmacol Rep. 2024;44(1):206-15. Epub 20240213. doi: 10.1002/npr2.12423. PubMed PMID: 38348613; PMCID: PMC10932790.
186. Lieberman JA, Girgis RR, Brucato G, Moore H, Provenzano F, Kegeles L, Javitt D, Kantrowitz J, Wall MM, Corcoran CM, Schobel SA, Small SA. Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention. Mol Psychiatry. 2018;23(8):1764-72. Epub 20180109. doi: 10.1038/mp.2017.249. PubMed PMID: 29311665; PMCID: PMC6037569.
187. Heckers S, Konradi C. Hippocampal Pathology in Schizophrenia. Current Topics in Behavioral Neurosciences: Springer Berlin Heidelberg; 2010. p. 529-53.
188. Seidman LJ, Pantelis C, Keshavan MS, Faraone SV, Goldstein JM, Horton NJ, Makris N, Peter F, Caviness VS, Tsuang MT. A Review and New Report of Medial Temporal Lobe Dysfunction as a Vulnerability Indicator for Schizophrenia: A Magnetic Resonance Imaging Morphometric Family Study of the Parahippocampal Gyrus. Schizophrenia Bulletin. 2003;29(4):803-30. doi: 10.1093/oxfordjournals.schbul.a007048.
189. Sim K, DeWitt I, Ditman T, Zalesak M, Greenhouse I, Goff D, Weiss AP, Heckers S. Hippocampal and parahippocampal volumes in schizophrenia: a structural MRI study. Schizophr Bull. 2006;32(2):332-40. Epub 20051130. doi: 10.1093/schbul/sbj030. PubMed PMID: 16319377; PMCID: PMC2632210.
190. Karnik-Henry MS, Wang L, Barch DM, Harms MP, Campanella C, Csernansky JG. Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblings. Schizophrenia Research. 2012;138(2-3):128-35. doi: 10.1016/j.schres.2012.03.015.
191. Makhdoum RM, Alahmadi AAS. Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks. Diagnostics (Basel). 2025;15(15):1955. Epub 20250804. doi: 10.3390/diagnostics15151955. PubMed PMID: 40804922; PMCID: PMC12345939.
192. Libby LA, Yonelinas AP, Ranganath C, Ragland JD. Recollection and familiarity in schizophrenia: a quantitative review. Biol Psychiatry. 2013;73(10):944-50. Epub 20121214. doi: 10.1016/j.biopsych.2012.10.027. PubMed PMID: 23245761; PMCID: PMC3609900.
193. Murray EA, Bussey TJ, Saksida LM. Visual perception and memory: A new view of medial temporal lobe function in primates and rodents. Annu Rev Neurosci. 2007; 30:99–122. Doi:10.1146/annurev.neuro.29.051605.113046.
2. Warrington EK, Weiskrantz L. Organisational aspects of memory in amnesic patients. Neuropsychologia. 1971;9(1):67-73. doi: 10.1016/0028-3932(71)90063-7. PubMed PMID: 5146487.
3. Squire LR. Declarative and Nondeclarative Memory: Multiple Brain Systems Supporting Learning and Memory. Memory Systems 1994: The MIT Press; 1994. p. 203-31.
4. Malamut BL, Saunders RC, Mishkin M. Monkeys with combined amygdalo-hippocampal lesions succeed in object discrimination learning despite 24-hour intertrial intervals. Behav Neurosci. 1984;98(5):759-69. doi: 10.1037//0735-7044.98.5.759. PubMed PMID: 6487412.
5. Meunier M, Bachevalier J, Mishkin M, Murray EA. Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. J Neurosci. 1993;13(12):5418-32. doi: 10.1523/JNEUROSCI.13-12-05418.1993. PubMed PMID: 8254384; PMCID: PMC6576426.
6. Meunier M, Hadfield W, Bachevalier J, Murray EA. Effects of rhinal cortex lesions combined with hippocampectomy on visual recognition memory in rhesus monkeys. J Neurophysiol. 1996;75(3):1190-205. doi: 10.1152/jn.1996.75.3.1190. PubMed PMID: 8867128.
7. Baxter MG, Murray EA. Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys. Hippocampus. 2001;11(1):61-71. doi: 10.1002/1098-1063(2001)11:1<61::AID-HIPO1021>3.0.CO;2-Z. PubMed PMID: 11261774.
8. Heuer E, Bachevalier J. Effects of selective neonatal hippocampal lesions on tests of object and spatial recognition memory in monkeys. Behav Neurosci. 2011;125(2):137-49. doi: 10.1037/a0022539. PubMed PMID: 21341885; PMCID: PMC3072249.
9. Murray EA, Mishkin M. Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and hippocampus. J Neurosci. 1998;18(16):6568-82. doi: 10.1523/JNEUROSCI.18-16-06568.1998. PubMed PMID: 9698344; PMCID: PMC6793180.
10. Beason-Held LL, Rosene DL, Killiany RJ, Moss MB. Hippocampal formation lesions produce memory impairment in the rhesus monkey. Hippocampus. 1999;9(5):562-74. doi: 10.1002/(SICI)1098-1063(1999)9:5<562::AID-HIPO10>3.0.CO;2-X. PubMed PMID: 10560927.
11. Zola SM, Squire LR, Teng E, Stefanacci L, Buffalo EA, Clark RE. Impaired recognition memory in monkeys after damage limited to the hippocampal region. J Neurosci. 2000;20(1):451-63. doi: 10.1523/JNEUROSCI.20-01-00451.2000. PubMed PMID: 10627621; PMCID: PMC6774137.
12. Murray EA. Quality Controls: The Role of Self‐Corrective Science in Explorations of Primate Memory Systems. Hippocampus. 2024;35(1). doi: 10.1002/hipo.23667.
13. Brodmann K. Vergleichende lokalisationslehre der grobhirnrinde. Vergleichende lokalisationslehre der grobhirnrinde1909. p. 324-.
14. Suzuki WA, Amaral DG. Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices. The Journal of Neuroscience. 1994;14(3):1856-77. doi: 10.1523/jneurosci.14-03-01856.1994.
15. Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents. J Comp Neurol. 1994;350(4):497-533. doi: 10.1002/cne.903500402. PubMed PMID: 7890828.
16. Suzuki WA. The anatomy, physiology and functions of the perirhinal cortex. Curr Opin Neurobiol. 1996;6(2):179-86. doi: 10.1016/s0959-4388(96)80071-7. PubMed PMID: 8725959.
17. Ding SL, Van Hoesen GW. Borders, extent, and topography of human perirhinal cortex as revealed using multiple modern neuroanatomical and pathological markers. Human Brain Mapping. 2010;31(9):1359-79. doi: 10.1002/hbm.20940.
18. Miyashita Y. Perirhinal circuits for memory processing. Nat Rev Neurosci. 2019;20(10):577-92. Epub 20190904. doi: 10.1038/s41583-019-0213-6. PubMed PMID: 31485007.
19. Lavenex P, Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: projections to the neocortex. J Comp Neurol. 2002;447(4):394-420. doi: 10.1002/cne.10243. PubMed PMID: 11992524.
20. Insausti R, Amaral DG, Cowan WM. The entorhinal cortex of the monkey: II. Cortical afferents. J Comp Neurol. 1987;264(3):356-95. doi: 10.1002/cne.902640306. PubMed PMID: 2445796.
21. Amaral DG, Price JL. Amygdalo‐cortical projections in the monkey (Macaca fascicularis). Journal of Comparative Neurology. 2004;230(4):465-96. doi: 10.1002/cne.902300402.
22. Kondo H, Saleem KS, Price JL. Differential connections of the perirhinal and parahippocampal cortex with the orbital and medial prefrontal networks in macaque monkeys. J Comp Neurol. 2005;493(4):479-509. doi: 10.1002/cne.20796. PubMed PMID: 16304624.
23. Aggleton JP. Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function. Neuroscience & Biobehavioral Reviews. 2012;36(7):1579-96. doi: 10.1016/j.neubiorev.2011.09.005.
24. Saunders RC, Mishkin M, Aggleton JP. Projections from the entorhinal cortex, perirhinal cortex, presubiculum, and parasubiculum to the medial thalamus in macaque monkeys: identifying different pathways using disconnection techniques. Exp Brain Res. 2005;167(1):1-16. Epub 20051029. doi: 10.1007/s00221-005-2361-3. PubMed PMID: 16143859.
25. Baizer JS, Ungerleider LG, Desimone R. Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques. J Neurosci. 1991;11(1):168-90. doi: 10.1523/JNEUROSCI.11-01-00168.1991. PubMed PMID: 1702462; PMCID: PMC6575184.
26. Desimone R, Schein SJ, Moran J, Ungerleider LG. Contour, color and shape analysis beyond the striate cortex. Vision Res. 1985;25(3):441-52. doi: 10.1016/0042-6989(85)90069-0. PubMed PMID: 4024463.
27. Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc Natl Acad Sci U S A. 1991;88(5):1621-5. doi: 10.1073/pnas.88.5.1621. PubMed PMID: 2000370; PMCID: PMC51076.
28. Mishkin M, Ungerleider LG. Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behav Brain Res. 1982;6(1):57-77. doi: 10.1016/0166-4328(82)90081-x. PubMed PMID: 7126325.
29. Ungerleider LG, Haxby JV. ‘What’ and ‘where’ in the human brain. Current Opinion in Neurobiology. 1994;4(2):157-65. doi: 10.1016/0959-4388(94)90066-3.
30. Wilson HR, Wilkinson F. From orientations to objects: Configural processing in the ventral stream. J Vis. 2015;15(7):4. doi: 10.1167/15.7.4. PubMed PMID: 26024513.
31. Murray EA, Wise SP. Why is there a special issue on perirhinal cortex in a journal called hippocampus? The perirhinal cortex in historical perspective. Hippocampus. 2012;22(10):1941-51. doi: 10.1002/hipo.22055.
32. Murray EA, Richmond BJ. Role of perirhinal cortex in object perception, memory, and associations. Curr Opin Neurobiol. 2001;11(2):188-93. doi: 10.1016/s0959-4388(00)00195-1. PubMed PMID: 11301238.
33. Devlin JT, Price CJ. Perirhinal contributions to human visual perception. Curr Biol. 2007;17(17):1484-8. doi: 10.1016/j.cub.2007.07.066. PubMed PMID: 17764947; PMCID: PMC1971135.
34. Peterson MA, Cacciamani L, Barense MD, Scalf PE. The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity. Hippocampus. 2012;22(10):1965-77. doi: 10.1002/hipo.22065.
35. Barense MD, Ngo JKW, Hung LHT, Peterson MA. Interactions of Memory and Perception in Amnesia: The Figure–Ground Perspective. Cerebral Cortex. 2012;22(11):2680-91. doi: 10.1093/cercor/bhr347.
36. Bussey TJ, Saksida LM, Murray EA. Perirhinal cortex resolves feature ambiguity in complex visual discriminations. Eur J Neurosci. 2002;15(2):365-74. doi: 10.1046/j.0953-816x.2001.01851.x. PubMed PMID: 11849302.
37. Bussey TJ, Saksida LM, Murray EA. Impairments in visual discrimination after perirhinal cortex lesions: testing ‘declarative’ vs. ‘perceptual‐mnemonic’ views of perirhinal cortex function. European Journal of Neuroscience. 2003;17(3):649-60. doi: 10.1046/j.1460-9568.2003.02475.x.
38. Bussey TJ, Saksida LM, Murray EA. The Perceptual-Mnemonic/Feature Conjunction Model of Perirhinal Cortex Function. The Quarterly Journal of Experimental Psychology Section B. 2005;58(3-4b):269-82. doi: 10.1080/02724990544000004.
39. Bussey TJ, Saksida LM, Murray EA. Perirhinal cortex and feature-ambiguous discriminations. Learn Mem. 2006;13(2):103-5; author reply 6-7. doi: 10.1101/lm.163606. PubMed PMID: 16585785.
40. Hales JB, Broadbent NJ, Velu PD, Squire LR, Clark RE. Hippocampus, perirhinal cortex, and complex visual discriminations in rats and humans. Learn Mem. 2015;22(2):83-91. Epub 20150115. doi: 10.1101/lm.035840.114. PubMed PMID: 25593294; PMCID: PMC4341362.
41. Malkova L, Bachevalier J, Webster M, Mishkin M. Effects of neonatal inferior prefrontal and medial temporal lesions on learning the rule for delayed nonmatching-to-sample. Dev Neuropsychol. 2000;18(3):399-421. doi: 10.1207/S1532694207Malkova. PubMed PMID: 11385832.
42. Mumby DG, Pinel JP. Rhinal cortex lesions and object recognition in rats. Behav Neurosci. 1994;108(1):11-8. doi: 10.1037//0735-7044.108.1.11. PubMed PMID: 8192836.
43. Nemanic S, Alvarado MC, Bachevalier J. The Hippocampal/Parahippocampal Regions and Recognition Memory: Insights from Visual Paired Comparison versus Object-Delayed Nonmatching in Monkeys. The Journal of Neuroscience. 2004;24(8):2013-26. doi: 10.1523/jneurosci.3763-03.2004.
44. Wan H, Aggleton JP, Brown MW. Different contributions of the hippocampus and perirhinal cortex to recognition memory. J Neurosci. 1999;19(3):1142-8. doi: 10.1523/JNEUROSCI.19-03-01142.1999. PubMed PMID: 9920675; PMCID: PMC6782155.
45. Bowles B, Crupi C, Mirsattari SM, Pigott SE, Parrent AG, Pruessner JC, Yonelinas AP, Köhler S. Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus. Proceedings of the National Academy of Sciences. 2007;104(41):16382-7. doi: 10.1073/pnas.0705273104.
46. Schoemaker D, Gauthier S, Pruessner JC. Recollection and Familiarity in Aging Individuals with Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review. Neuropsychology Review. 2014;24(3):313-31. doi: 10.1007/s11065-014-9265-6.
47. Yonelinas AP, Kroll NE, Quamme JR, Lazzara MM, Sauve MJ, Widaman KF, Knight RT. Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity. Nat Neurosci. 2002;5(11):1236-41. doi: 10.1038/nn961. PubMed PMID: 12379865.
48. Mayes AR, Holdstock JS, Isaac CL, Montaldi D, Grigor J, Gummer A, Cariga P, Downes JJ, Tsivilis D, Gaffan D, Gong Q, Norman KA. Associative recognition in a patient with selective hippocampal lesions and relatively normal item recognition. Hippocampus. 2004;14(6):763-84. doi: 10.1002/hipo.10211. PubMed PMID: 15318334.
49. Aggleton J, Kyd R, Bilkey D. When is the perirhinal cortex necessary for the performance of spatial memory tasks? Neuroscience & Biobehavioral Reviews. 2004;28(6):611-24. doi: 10.1016/j.neubiorev.2004.08.007.
50. Staresina BP, Fell J, Do Lam AT, Axmacher N, Henson RN. Memory signals are temporally dissociated in and across human hippocampus and perirhinal cortex. Nat Neurosci. 2012;15(8):1167-73. Epub 20120701. doi: 10.1038/nn.3154. PubMed PMID: 22751037; PMCID: PMC3428860.
51. Staresina BP, Fell J, Dunn JC, Axmacher N, Henson RN. Using state-trace analysis to dissociate the functions of the human hippocampus and perirhinal cortex in recognition memory. Proc Natl Acad Sci U S A. 2013;110(8):3119-24. Epub 20130204. doi: 10.1073/pnas.1215710110. PubMed PMID: 23382181; PMCID: PMC3581882.
52. Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA. Remembering episodes: a selective role for the hippocampus during retrieval. Nat Neurosci. 2000;3(11):1149-52. doi: 10.1038/80671. PubMed PMID: 11036273.
53. Vilberg KL, Rugg MD. Dissociation of the neural correlates of recognition memory according to familiarity, recollection, and amount of recollected information. Neuropsychologia. 2007;45(10):2216-25. Epub 20070312. doi: 10.1016/j.neuropsychologia.2007.02.027. PubMed PMID: 17449068; PMCID: PMC1933497.
54. Yonelinas AP. Unpacking the Medial Temporal Lobe: Separating Recollection and Familiarity. Hippocampus. 2025;35(5):e70033. doi: 10.1002/hipo.70033. PubMed PMID: 40919742; PMCID: PMC12416122.
55. Cannon TD, Glahn DC, Kim J, Van Erp TG, Karlsgodt K, Cohen MS, Nuechterlein KH, Bava S, Shirinyan D. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch Gen Psychiatry. 2005;62(10):1071-80. doi: 10.1001/archpsyc.62.10.1071. PubMed PMID: 16203952.
56. D'Esposito M, Postle BR, Ballard D, Lease J. Maintenance versus Manipulation of Information Held in Working Memory: An Event-Related fMRI Study. Brain and Cognition. 1999;41(1):66-86. doi: 10.1006/brcg.1999.1096.
57. Glahn DC, Kim J, Cohen MS, Poutanen VP, Therman S, Bava S, Van Erp TG, Manninen M, Huttunen M, Lonnqvist J, Standertskjold-Nordenstam CG, Cannon TD. Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage. 2002;17(1):201-13. doi: 10.1006/nimg.2002.1161. PubMed PMID: 12482077.
58. Petrides M. Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey. J Neurosci. 1995;15(1 Pt 1):359-75. doi: 10.1523/JNEUROSCI.15-01-00359.1995. PubMed PMID: 7823141; PMCID: PMC6578311.
59. Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SPMJ, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD. Redefining the functional organization of working memory processes within human lateral prefrontal cortex. European Journal of Neuroscience. 1999;11(2):567-74. doi: 10.1046/j.1460-9568.1999.00449.x.
60. Petrides M. Monitoring of selections of visual stimuli and the primate frontal cortex. Proc Biol Sci. 1991;246(1317):293-8. doi: 10.1098/rspb.1991.0157. PubMed PMID: 1686095.
61. Petrides M. Functional specialization within the dorsolateral frontal cortex for serial order memory. Proc Biol Sci. 1991;246(1317):299-306. doi: 10.1098/rspb.1991.0158. PubMed PMID: 1686096.
62. Kowalska DM, Bachevalier J, Mishkin M. The role of the inferior prefrontal convexity in performance of delayed nonmatching-to-sample. Neuropsychologia. 1991;29(6):583-600. doi: 10.1016/0028-3932(91)90012-w. PubMed PMID: 1944863.
63. Miller EK, Buschman TJ. Cortical circuits for the control of attention. Curr Opin Neurobiol. 2013;23(2):216-22. Epub 20121222. doi: 10.1016/j.conb.2012.11.011. PubMed PMID: 23265963; PMCID: PMC3709832.
64. Mishkin M, Manning FJ. Non-spatial memory after selective prefrontal lesions in monkeys. Brain Res. 1978;143(2):313-23. doi: 10.1016/0006-8993(78)90571-1. PubMed PMID: 415803.
65. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24(1):167-202. doi: 10.1146/annurev.neuro.24.1.167. PubMed PMID: 11283309.
66. Passingham R. Delayed matching after selective prefrontal lesions in monkeys (Macaca mulatta). Brain Res. 1975;92(1):89-102. doi: 10.1016/0006-8993(75)90529-6. PubMed PMID: 809096.
67. Constantinidis C, Procyk E. The primate working memory networks. Cogn Affect Behav Neurosci. 2004;4(4):444-65. doi: 10.3758/cabn.4.4.444. PubMed PMID: 15849890; PMCID: PMC3885185.
68. Davachi L, Goldman-Rakic PS. Primate Rhinal Cortex Participates in Both Visual Recognition and Working Memory Tasks: Functional Mapping With 2-DG. Journal of Neurophysiology. 2001;85(6):2590-601. doi: 10.1152/jn.2001.85.6.2590.
69. Kimble DP, Pribram KH. Hippocampectomy and behavior sequences. Science. 1963;139(3557):824-5. doi: 10.1126/science.139.3557.824. PubMed PMID: 14032718.
70. Libby LA, Ekstrom AD, Ragland JD, Ranganath C. Differential Connectivity of Perirhinal and Parahippocampal Cortices within Human Hippocampal Subregions Revealed by High-Resolution Functional Imaging. The Journal of Neuroscience. 2012;32(19):6550-60. doi: 10.1523/jneurosci.3711-11.2012.
71. Petrides M. The role of the mid-dorsolateral prefrontal cortex in working memory. Executive Control and the Frontal Lobe: Current Issues: Springer Berlin Heidelberg; 2000. p. 44-54.
72. Ranganath C, Cohen MX, Dam C, D'Esposito M. Inferior temporal, prefrontal, and hippocampal contributions to visual working memory maintenance and associative memory retrieval. J Neurosci. 2004;24(16):3917-25. doi: 10.1523/JNEUROSCI.5053-03.2004. PubMed PMID: 15102907; PMCID: PMC6729418.
73. Stern CE, Sherman SJ, Kirchhoff BA, Hasselmo ME. Medial temporal and prefrontal contributions to working memory tasks with novel and familiar stimuli. Hippocampus. 2001;11(4):337-46. doi: 10.1002/hipo.1048. PubMed PMID: 11530838.
74. Lehky SR, Tanaka K. Enhancement of object representations in primate perirhinal cortex during a visual working-memory task. J Neurophysiol. 2007;97(2):1298-310. Epub 20061115. doi: 10.1152/jn.00167.2006. PubMed PMID: 17108097.
75. Owen AM, Roberts AC, Hodges JR, Robbins TW. Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease. Brain. 1993;116(5):1159-75. doi: 10.1093/brain/116.5.1159.
76. Postle BR, Brush LN, Nick AM. Prefrontal cortex and the mediation of proactive interference in working memory. Cogn Affect Behav Neurosci. 2004;4(4):600-8. doi: 10.3758/cabn.4.4.600. PubMed PMID: 15849900; PMCID: PMC1201535.
77. Ridderinkhof KR, Span MM, van der Molen MW. Perseverative behavior and adaptive control in older adults: performance monitoring, rule induction, and set shifting. Brain Cogn. 2002;49(3):382-401. doi: 10.1006/brcg.2001.1506. PubMed PMID: 12139960.
78. Jha AP, Fabian SA, Aguirre GK. The role of prefrontal cortex in resolving distractor interference. Cogn Affect Behav Neurosci. 2004;4(4):517-27. doi: 10.3758/cabn.4.4.517. PubMed PMID: 15849894.
79. Monchi O, Petrides M, Petre V, Worsley K, Dagher A. Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imaging. J Neurosci. 2001;21(19):7733-41. doi: 10.1523/JNEUROSCI.21-19-07733.2001. PubMed PMID: 11567063; PMCID: PMC6762921.
80. Collins P, Roberts AC, Dias R, Everitt BJ, Robbins TW. Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex. J Cogn Neurosci. 1998;10(3):332-54. doi: 10.1162/089892998562771. PubMed PMID: 9869708.
81. Petrides M, Milner B. Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia. 1982;20(3):249-62. doi: 10.1016/0028-3932(82)90100-2. PubMed PMID: 7121793.
82. Ross TP, Hanouskova E, Giarla K, Calhoun E, Tucker M. The reliability and validity of the self-ordered pointing task. Arch Clin Neuropsychol. 2007;22(4):449-58. Epub 20070223. doi: 10.1016/j.acn.2007.01.023. PubMed PMID: 17321716.
83. Bissonette GB, Powell EM, Roesch MR. Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex. Behav Brain Res. 2013;250:91-101. Epub 20130509. doi: 10.1016/j.bbr.2013.04.037. PubMed PMID: 23664821; PMCID: PMC3708542.
84. Burnham KE, Bannerman DM, Dawson LA, Southam E, Sharp T, Baxter MG. Fos expression in the brains of rats performing an attentional set-shifting task. Neuroscience. 2010;171(2):485-95. Epub 20100916. doi: 10.1016/j.neuroscience.2010.09.008. PubMed PMID: 20849932; PMCID: PMC2989446.
85. Dias R, Robbins TW, Roberts AC. Dissociable Forms of Inhibitory Control within Prefrontal Cortex with an Analog of the Wisconsin Card Sort Test: Restriction to Novel Situations and Independence from “On-Line” Processing. The Journal of Neuroscience. 1997;17(23):9285-97. doi: 10.1523/jneurosci.17-23-09285.1997.
86. Rogers RD, Andrews TC, Grasby PM, Brooks DJ, Robbins TW. Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci. 2000;12(1):142-62. doi: 10.1162/089892900561931. PubMed PMID: 10769312.
87. Barbas H, Pandya DN. Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol. 1989;286(3):353-75. doi: 10.1002/cne.902860306. PubMed PMID: 2768563.
88. Petrides M, Pandya DN. Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey. Eur J Neurosci. 2002;16(2):291-310. doi: 10.1046/j.1460-9568.2001.02090.x. PubMed PMID: 12169111.
89. Murray EA, Baxter MG, Gaffan D. Monkeys with rhinal cortex damage or neurotoxic hippocampal lesions are impaired on spatial scene learning and object reversals. Behav Neurosci. 1998;112(6):1291-303. doi: 10.1037//0735-7044.112.6.1291. PubMed PMID: 9926813.
90. Hampton RR, Murray EA. Learning of discriminations is impaired, but generalization to altered views is intact, in monkeys (Macaca mulatta) with perirhinal cortex removal. Behav Neurosci. 2002;116(3):363-77. doi: 10.1037//0735-7044.116.3.363. PubMed PMID: 12049317.
91. Owen AM, Roberts AC, Polkey CE, Sahakian BJ, Robbins TW. Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia. 1991;29(10):993-1006. doi: 10.1016/0028-3932(91)90063-e. PubMed PMID: 1762678.
92. Otto T, Cousens G, Herzog C. Behavioral and neuropsychological foundations of olfactory fear conditioning. Behav Brain Res. 2000;110(1-2):119-28. doi: 10.1016/s0166-4328(99)00190-4. PubMed PMID: 10802309.
93. Gray JA, McNaughton N. The Neuropsychology of Anxiety: An Enquiry Into the Function of the Septo-hippocampal System: Oxford University Press; 2003.
94. Paz R, Pelletier JG, Bauer EP, Pare D. Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions. Nat Neurosci. 2006;9(10):1321-9. Epub 20060910. doi: 10.1038/nn1771. PubMed PMID: 16964249.
95. Paz R, Pare D. Physiological basis for emotional modulation of memory circuits by the amygdala. Curr Opin Neurobiol. 2013;23(3):381-6. Epub 20130205. doi: 10.1016/j.conb.2013.01.008. PubMed PMID: 23394774; PMCID: PMC3652906.
96. Paz R, Bauer EP, Pare D. Learning-related facilitation of rhinal interactions by medial prefrontal inputs. J Neurosci. 2007;27(24):6542-51. doi: 10.1523/JNEUROSCI.1077-07.2007. PubMed PMID: 17567815; PMCID: PMC6672438.
97. Meunier M, Bachevalier J. Comparison of emotional responses in monkeys with rhinal cortex or amygdala lesions. Emotion. 2002;2(2):147-61. doi: 10.1037/1528-3542.2.2.147. PubMed PMID: 12899188.
98. Meunier M, Cirilli L, Bachevalier J. Responses to affective stimuli in monkeys with entorhinal or perirhinal cortex lesions. J Neurosci. 2006;26(29):7718-22. doi: 10.1523/JNEUROSCI.1949-06.2006. PubMed PMID: 16855099; PMCID: PMC6674284.
99. Pascalis O, de Schonen S. Recognition memory in 3− to 4-day-old human neonates. NeuroReport. 1994;5(14):1721-4. doi: 10.1097/00001756-199409080-00008.
100. Pascalis O, de Haan M, Nelson CA, de Schonen S. Long-term recognition memory for faces assessed by visual paired comparison in 3- and 6-month-old infants. J Exp Psychol Learn Mem Cogn. 1998;24(1):249-60. doi: 10.1037//0278-7393.24.1.249. PubMed PMID: 9438961.
101. Gunderson VM, Sackett GP. Development of pattern recognition in infant pigtailed macaques (Macaca nemestrina). Developmental Psychology. 1984;20(3):418-26. doi: 10.1037/0012-1649.20.3.418.
102. Zeamer A, Heuer E, Bachevalier J. Developmental Trajectory of Object Recognition Memory in Infant Rhesus Macaques with and without Neonatal Hippocampal Lesions. Journal of Neuroscience. 2010;30(27):9157-65. doi: 10.1523/jneurosci.0022-10.2010.
103. Zeamer A, Richardson RL, Weiss AR, Bachevalier J. The development of object recognition memory in rhesus macaques with neonatal lesions of the perirhinal cortex. Dev Cogn Neurosci. 2015;11:31-41. Epub 20140721. doi: 10.1016/j.dcn.2014.07.002. PubMed PMID: 25096364; PMCID: PMC4302071.
104. Weiss AR, Bachevalier J. Object and spatial memory after neonatal perirhinal lesions in monkeys. Behav Brain Res. 2016;298(Pt B):210-7. Epub 20151123. doi: 10.1016/j.bbr.2015.11.010. PubMed PMID: 26593109; PMCID: PMC4688056.
105. Blue SN, Kazama AM, Bachevalier J. Development of Memory for Spatial Locations and Object/Place Associations in Infant Rhesus Macaques with and without Neonatal Hippocampal Lesions. Journal of the International Neuropsychological Society. 2013;19(10):1053-64. doi: 10.1017/s1355617713000799.
106. Zeamer A, Meunier M, Bachevalier J. Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions. Learn Mem. 2011;18(3):170-80. Epub 20110225. doi: 10.1101/lm.2076811. PubMed PMID: 21357439; PMCID: PMC3056513.
107. Zeamer A, Bachevalier J. Long-term effects of neonatal hippocampal lesions on novelty preference in monkeys. Hippocampus. 2013;23(9):745-50. Epub 20130606. doi: 10.1002/hipo.22139. PubMed PMID: 23640834; PMCID: PMC3775855.
108. Lavenex P. Functional Anatomy, Development, and Pathology of the Hippocampus. The Clinical Neurobiology of the Hippocampus: Oxford University Press; 2012. p. 10-38.
109. Lavenex P, Banta Lavenex P, Amaral DG. Postnatal Development of the Primate Hippocampal Formation. Developmental Neuroscience. 2007;29(1-2):179-92. doi: 10.1159/000096222.
110. Payne C, Machado CJ, Bliwise NG, Bachevalier J. Maturation of the hippocampal formation and amygdala in Macaca mulatta: A volumetric magnetic resonance imaging study. Hippocampus. 2010;20(8):922-35. doi: 10.1002/hipo.20688.
111. Cioni G, D'Acunto G, Guzzetta A. Perinatal brain damage in children: neuroplasticity, early intervention, and molecular mechanisms of recovery. Prog Brain Res. 2011;189:139-54. doi: 10.1016/B978-0-444-53884-0.00022-1. PubMed PMID: 21489387.
112. Goldman PS, Rosvold HE, Mishkin M. Selective sparing of function following prefrontal lobectomy in infant monkeys. Exp Neurol. 1970;29(2):221-6. doi: 10.1016/0014-4886(70)90053-1. PubMed PMID: 4994109.
113. Miller EA, Goldman PS, Rosvold HE. Delayed recovery of function following orbital prefrontal lesions in infant monkeys. Science. 1973;182(4109):304-6. doi: 10.1126/science.182.4109.304. PubMed PMID: 4200506.
114. Kolb B, Gibb R. Brain plasticity and behaviour in the developing brain. J Can Acad Child Adolesc Psychiatry. 2011;20(4):265-76. PubMed PMID: 22114608; PMCID: PMC3222570.
115. Kolb B, Mychasiuk R, Muhammad A, Gibb R. Brain plasticity in the developing brain. Prog Brain Res. 2013;207:35-64. doi: 10.1016/B978-0-444-63327-9.00005-9. PubMed PMID: 24309250.
116. Gaffan D. Dissociated effects of perirhinal cortex ablation, fornix transection and amygdalectomy: evidence for multiple memory systems in the primate temporal lobe. Exp Brain Res. 1994;99(3):411-22. doi: 10.1007/BF00228977. PubMed PMID: 7957720.
117. Aggleton JP, Keen S, Warburton EC, Bussey TJ. Extensive Cytotoxic Lesions Involving Both the Rhinal Cortices and Area TE Impair Recognition But Spare Spatial Alternation in the Rat. Brain Research Bulletin. 1997;43(3):279-87. doi: 10.1016/s0361-9230(97)00007-5.
118. Vann SD, Brown MW, Erichsen JT, Aggleton JP. Fos imaging reveals differential patterns of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests. J Neurosci. 2000;20(7):2711-8. doi: 10.1523/JNEUROSCI.20-07-02711.2000. PubMed PMID: 10729352; PMCID: PMC6772240.
119. Machin P, Vann SD, Muir JL, Aggleton JP. Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory. Behav Neurosci. 2002;116(2):232-40. doi: 10.1037//0735-7044.116.2.232. PubMed PMID: 11996309.
120. Winters BD, Forwood SE, Cowell RA, Saksida LM, Bussey TJ. Double Dissociation between the Effects of Peri-Postrhinal Cortex and Hippocampal Lesions on Tests of Object Recognition and Spatial Memory: Heterogeneity of Function within the Temporal Lobe. The Journal of Neuroscience. 2004;24(26):5901-8. doi: 10.1523/jneurosci.1346-04.2004.
121. Bachevalier J, Nemanic S. Memory for spatial location and object‐place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex. Hippocampus. 2007;18(1):64-80. doi: 10.1002/hipo.20369.
122. Ramos JM. Essential role of the perirhinal cortex in complex tactual discrimination tasks in rats. Cereb Cortex. 2014;24(8):2068-80. Epub 20130228. doi: 10.1093/cercor/bht054. PubMed PMID: 23448873.
123. Wiig KA, Bilkey DK. Perirhinal cortex lesions in rats disrupt performance in a spatial DNMS task. Neuroreport. 1994;5(11):1405-8. doi: 10.1097/00001756-199406000-00029. PubMed PMID: 7919210.
124. Wiig KA, Burwell RD. Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat. Behav Neurosci. 1998;112(4):827-38. doi: 10.1037//0735-7044.112.4.827. PubMed PMID: 9733190.
125. Alvarado MC, Bachevalier J. Comparison of the effects of damage to the perirhinal and parahippocampal cortex on transverse patterning and location memory in rhesus macaques. J Neurosci. 2005;25(6):1599-609. doi: 10.1523/JNEUROSCI.4457-04.2005. PubMed PMID: 15703414; PMCID: PMC6725995.
126. Hampton RR. Monkey perirhinal cortex is critical for visual memory, but not for visual perception: reexamination of the behavioural evidence from monkeys. Q J Exp Psychol B. 2005;58(3-4):283-99. doi: 10.1080/02724990444000195. PubMed PMID: 16194970.
127. Weiss AR, Guo W, Richardson R, Bachevalier J. Intact perceptual ability, but impaired familiarity judgment, after neonatal perirhinal lesions in rhesus macaques. Dev Cogn Neurosci. 2017;28:54-64. Epub 20171031. doi: 10.1016/j.dcn.2017.10.006. PubMed PMID: 29175539; PMCID: PMC5737963.
128. Browning PG, Baxter MG, Gaffan D. Prefrontal-temporal disconnection impairs recognition memory but not familiarity discrimination. J Neurosci. 2013;33(23):9667-74. doi: 10.1523/JNEUROSCI.5759-12.2013. PubMed PMID: 23739963; PMCID: PMC3797511.
129. Kazama AM, Davis M, Bachevalier J. Neonatal lesions of orbital frontal areas 11/13 in monkeys alter goal-directed behavior but spare fear conditioning and safety signal learning. Front Neurosci. 2014;8:37. Epub 20140304. doi: 10.3389/fnins.2014.00037. PubMed PMID: 24624054; PMCID: PMC3940964.
130. Weiss AR, Nadji R, Bachevalier J. Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference. Front Syst Neurosci. 2015;9:179. Epub 20160105. doi: 10.3389/fnsys.2015.00179. PubMed PMID: 26778978; PMCID: PMC4700260.
131. Weiss AR, White J, Richardson R, Bachevalier J. Impaired Cognitive Flexibility After Neonatal Perirhinal Lesions in Rhesus Macaques. Front Syst Neurosci. 2019;13:6. Epub 2019/02/15. doi: 10.3389/fnsys.2019.00006. PubMed PMID: 30760985; PMCID: PMC6363703.
132. Cavada C, Company T, Tejedor J, Cruz-Rizzolo RJ, Reinoso-Suarez F. The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb Cortex. 2000;10(3):220-42. doi: 10.1093/cercor/10.3.220. PubMed PMID: 10731218.
133. Croxson PL, Johansen-Berg H, Behrens TE, Robson MD, Pinsk MA, Gross CG, Richter W, Richter MC, Kastner S, Rushworth MF. Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography. J Neurosci. 2005;25(39):8854-66. doi: 10.1523/JNEUROSCI.1311-05.2005. PubMed PMID: 16192375; PMCID: PMC6725599.
134. Vismer MS, Forcelli PA, Skopin MD, Gale K, Koubeissi MZ. The piriform, perirhinal, and entorhinal cortex in seizure generation. Front Neural Circuits. 2015;9:27. Epub 20150529. doi: 10.3389/fncir.2015.00027. PubMed PMID: 26074779; PMCID: PMC4448038.
135. Curot J, Busigny T, Valton L, Denuelle M, Vignal J-P, Maillard L, Chauvel P, Pariente J, Trebuchon A, Bartolomei F, Barbeau EJ. Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena. Neuroscience & Biobehavioral Reviews. 2017;78:161-77. doi: 10.1016/j.neubiorev.2017.04.018.
136. Bonilha L, Kobayashi E, Rorden C, Cendes F, Li LM. Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2003;74(12):1627-30. doi: 10.1136/jnnp.74.12.1627. PubMed PMID: 14638879; PMCID: PMC1757422.
137. Gloor P. Experiential phenomena of temporal lobe epilepsy. Facts and hypotheses. Brain. 1990;113 ( Pt 6)(6):1673-94. doi: 10.1093/brain/113.6.1673. PubMed PMID: 2276040.
138. Gloor P, Olivier A, Quesney LF, Andermann F, Horowitz S. The role of the limbic system in experiential phenomena of temporal lobe epilepsy. Ann Neurol. 1982;12(2):129-44. doi: 10.1002/ana.410120203. PubMed PMID: 7125603.
139. Jackson JH, Colman WS. Case of Epilepsy with Tasting Movements and “Dreamy State”—Very Small Patch of Softening in the Left Uncinate Gyrus. Brain. 1898;21(4):580-90. doi: 10.1093/brain/21.4.580.
140. Jackson JH, Stewart P. Epileptic Attacks with a Warning of a Crude Sensation of Smell and with the Intellectual Aura (Dreamy State) in a Patient Who Had Symptoms Pointing to Gross Organic Disease of the Right Temporo-Sphenoidal Lobe. Brain. 1899;22(4):534-49. doi: 10.1093/brain/22.4.534.
141. Penfield W. Some Mechanisms of Consciousness Discovered during Electrical Stimulation of the Brain. Proceedings of the National Academy of Sciences. 1958;44(2):51-66. doi: 10.1073/pnas.44.2.51.
142. Vignal JP, Maillard L, McGonigal A, Chauvel P. The dreamy state: hallucinations of autobiographic memory evoked by temporal lobe stimulations and seizures. Brain. 2007;130(Pt 1):88-99. Epub 20061130. doi: 10.1093/brain/awl329. PubMed PMID: 17142246.
143. Bartolomei F, Barbeau E, Gavaret M, Guye M, McGonigal A, Régis J, Chauvel P. Cortical stimulation study of the role of rhinal cortex in déjà vu and reminiscence of memories. Neurology. 2004;63(5):858-64. doi: 10.1212/01.Wnl.0000137037.56916.3f.
144. Guedj E, Aubert S, McGonigal A, Mundler O, Bartolomei F. Déjà-vu in temporal lobe epilepsy: Metabolic pattern of cortical involvement in patients with normal brain MRI. Neuropsychologia. 2010;48(7):2174-81. doi: 10.1016/j.neuropsychologia.2010.04.009.
145. Takeda Y, Kurita T, Sakurai K, Shiga T, Tamaki N, Koyama T. Persistent déjà vu associated with hyperperfusion in the entorhinal cortex. Epilepsy & Behavior. 2011;21(2):196-9. doi: 10.1016/j.yebeh.2011.03.031.
146. Weinand ME, Hermann B, Wyler AR, Carter LP, Oommen KJ, Labiner D, Ahern G, Herring A. Long-term subdural strip electrocorticographic monitoring of ictal deja vu. Epilepsia. 1994;35(5):1054-9. doi: 10.1111/j.1528-1157.1994.tb02554.x. PubMed PMID: 7925151.
147. Cataldi M, Avoli M, de Villers-Sidani E. Resting state networks in temporal lobe epilepsy. Epilepsia. 2013;54(12):2048-59. Epub 20131010. doi: 10.1111/epi.12400. PubMed PMID: 24117098; PMCID: PMC4880458.
148. Aggleton JP, Brown MW. Episodic memory, amnesia, and the hippocampal–anterior thalamic axis. Behavioral and Brain Sciences. 1999;22(3):425-44. doi: 10.1017/s0140525x99002034.
149. Eichenbaum H. A cortical–hippocampal system for declarative memory. Nature Reviews Neuroscience. 2000;1(1):41-50. doi: 10.1038/35036213.
150. Squire LR, Wixted JT, Clark RE. Recognition memory and the medial temporal lobe: a new perspective. Nat Rev Neurosci. 2007;8(11):872-83. doi: 10.1038/nrn2154. PubMed PMID: 17948032; PMCID: PMC2323975.
151. Montaldi D, Mayes AR. The role of recollection and familiarity in the functional differentiation of the medial temporal lobes. Hippocampus. 2010;20(11):1291-314. doi: 10.1002/hipo.20853. PubMed PMID: 20928828.
152. Spatt J. Déjà Vu: Possible Parahippocampal Mechanisms. The Journal of Neuropsychiatry and Clinical Neurosciences. 2002;14(1):6-10. doi: 10.1176/jnp.14.1.6.
153. Martin CB, Mirsattari SM, Pruessner JC, Pietrantonio S, Burneo JG, Hayman-Abello B, Köhler S. Déjà vu in unilateral temporal-lobe epilepsy is associated with selective familiarity impairments on experimental tasks of recognition memory. Neuropsychologia. 2012;50(13):2981-91. doi: 10.1016/j.neuropsychologia.2012.07.030.
154. Fernandez G, Tendolkar I. The rhinal cortex: ‘gatekeeper’ of the declarative memory system. Trends in Cognitive Sciences. 2006;10(8):358-62. doi: 10.1016/j.tics.2006.06.003.
155. Suzuki WA, Naya Y. The perirhinal cortex. Annu Rev Neurosci. 2014;37(1):39-53. doi: 10.1146/annurev-neuro-071013-014207. PubMed PMID: 25032492.
156. Long JM, Holtzman DM. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell. 2019;179(2):312-39. Epub 20190926. doi: 10.1016/j.cell.2019.09.001. PubMed PMID: 31564456; PMCID: PMC6778042.
157. Morris JC, Kimberly A, Quaid K, Holtzman DM, Kantarci K, Kaye J, Reiman EM, Klunk WE, Siemers ER. Role of biomarkers in studies of presymptomatic Alzheimer's disease. Alzheimer's & Dementia. 2005;1(2):145-51. doi: 10.1016/j.jalz.2005.09.013.
158. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Jr., Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):280-92. Epub 20110421. doi: 10.1016/j.jalz.2011.03.003. PubMed PMID: 21514248; PMCID: PMC3220946.
159. Giannakopoulos P, Herrmann FR, Bussière T, Bouras C, Kövari E, Perl DP, Morrison JH, Gold G, Hof PR. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease. Neurology. 2003;60(9):1495-500. doi: 10.1212/01.Wnl.0000063311.58879.01.
160. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239-59. doi: 10.1007/BF00308809. PubMed PMID: 1759558.
161. Bobinski M, Wegiel J, Tarnawski M, Bobinski M, Reisberg B, De Leon MJ, Miller DC, Wisniewski HM. Relationships between Regional Neuronal Loss and Neurofibrillary Changes in the Hippocampal Formation and Duration and Severity of Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. 1997;56(4):414-20. doi: 10.1097/00005072-199704000-00010.
162. Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol. 1997;41(1):17-24. doi: 10.1002/ana.410410106. PubMed PMID: 9005861.
163. Suzuki WA. Making new memories: the role of the hippocampus in new associative learning. Ann N Y Acad Sci. 2007;1097(1):1-11. doi: 10.1196/annals.1379.007. PubMed PMID: 17413005.
164. Pihlajamäki M, Soininen H. Alzheimer’s Disease. The Clinical Neurobiology of the Hippocampus: Oxford University Press; 2012. p. 223-44.
165. van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM. Hippocampal atrophy in Alzheimer disease: Age matters. Neurology. 2006;66(2):236-8. doi: 10.1212/01.wnl.0000194240.47892.4d.
166. De Leon M, George A, Stylopoulos L, Smith G, Miller D. Early Marker for Alzheimer's Disease: The Atrophic Hippocampus. The Lancet. 1989;334(8664):672-3. doi: 10.1016/s0140-6736(89)90911-2.
167. De Leon MJ, George AE, Golomb J, Tarshish C, Convit A, Kluger A, De Santi S, Mc Rae T, Ferris SH, Reisberg B, Ince C, Rusinek H, Bobinski M, Quinn B, Miller DC, Wisniewski HM. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiology of Aging. 1997;18(1):1-11. doi: 10.1016/s0197-4580(96)00213-8.
168. de Leon MJ, Smith G, George AE, McRae T, Golomb J, Convit A, Kluger A, Tsui W, Ferris SH, Wolf AP. CT, MRI, and PET Studies of Hippocampal Pathology in Alzheimer’s Disease. Neurodevelopment, Aging and Cognition: Birkhäuser Boston; 1992. p. 323-35.
169. Jack CR, Jr., Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Cha RH, Tangalos EG, Petersen RC. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology. 2004;62(4):591-600. doi: 10.1212/01.wnl.0000110315.26026.ef. PubMed PMID: 14981176; PMCID: PMC2730165.
170. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human Brain Mapping. 2009;30(9):2766-88. doi: 10.1002/hbm.20708.
171. Ridha BH, Anderson VM, Barnes J, Boyes RG, Price SL, Rossor MN, Whitwell JL, Jenkins L, Black RS, Grundman M, Fox NC. Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression. J Neurol. 2008;255(4):567-74. Epub 20080218. doi: 10.1007/s00415-008-0750-9. PubMed PMID: 18274807.
172. Qiu A, Fennema-Notestine C, Dale AM, Miller MI. Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. NeuroImage. 2009;45(3):656-61. doi: 10.1016/j.neuroimage.2009.01.013.
173. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hanninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala EL, Vainio P, Vanninen R, Partanen K, Soininen H. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging. 2004;25(3):303-10. doi: 10.1016/S0197-4580(03)00084-8. PubMed PMID: 15123335.
174. Forsberg A, Engler H, Almkvist O, Blomquist G, Hagman G, Wall A, Ringheim A, Langstrom B, Nordberg A. PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging. 2008;29(10):1456-65. Epub 20070511. doi: 10.1016/j.neurobiolaging.2007.03.029. PubMed PMID: 17499392.
175. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frölich L, Schönknecht P, Ito K, Mielke R, Kalbe E. Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PET. NeuroImage. 2002;17(1):302-16. doi: 10.1006/nimg.2002.1208.
176. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Clerici F, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon MJ. Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias. Journal of Nuclear Medicine. 2008;49(3):390-8. doi: 10.2967/jnumed.107.045385.
177. Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, Beckett LA, deToledo-Morrell L. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease ☆ ☆This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health. Neurobiology of Aging. 2001;22(5):747-54. doi: 10.1016/s0197-4580(01)00271-8.
178. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 2002;58(8):1188-96. doi: 10.1212/wnl.58.8.1188. PubMed PMID: 11971085.
179. Henzen NA, Abdulkadir A, Reinhardt J, Blatow M, Kressig RW, Krumm S. Automated segmentation for cortical thickness of the medial perirhinal cortex. Sci Rep. 2025;15(1):14903. Epub 20250428. doi: 10.1038/s41598-025-98399-w. PubMed PMID: 40295570; PMCID: PMC12037834.
180. Rapoport JL, Giedd JN, Gogtay N. Neurodevelopmental model of schizophrenia: update 2012. Mol Psychiatry. 2012;17(12):1228-38. Epub 20120410. doi: 10.1038/mp.2012.23. PubMed PMID: 22488257; PMCID: PMC3504171.
181. Kendler KS. What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. Molecular Psychiatry. 2013;18(10):1058-66. doi: 10.1038/mp.2013.50.
182. Harrison PJ. Recent genetic findings in schizophrenia and their therapeutic relevance. Journal of Psychopharmacology. 2014;29(2):85-96. doi: 10.1177/0269881114553647.
183. Andreasen NC. A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly. Arch Gen Psychiatry. 1999;56(9):781-7. doi: 10.1001/archpsyc.56.9.781. PubMed PMID: 12884883.
184. Karantonis JA, Carruthers SP, Rossell SL, Pantelis C, Hughes M, Wannan C, Cropley V, Van Rheenen TE. A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum. Schizophr Bull. 2021;47(6):1557-600. doi: 10.1093/schbul/sbab054. PubMed PMID: 34097043; PMCID: PMC8530395.
185. Yamazaki R, Matsumoto J, Ito S, Nemoto K, Fukunaga M, Hashimoto N, Kodaka F, Takano H, Hasegawa N, Yasuda Y, Fujimoto M, Yamamori H, Watanabe Y, Miura K, Hashimoto R. Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function. Neuropsychopharmacol Rep. 2024;44(1):206-15. Epub 20240213. doi: 10.1002/npr2.12423. PubMed PMID: 38348613; PMCID: PMC10932790.
186. Lieberman JA, Girgis RR, Brucato G, Moore H, Provenzano F, Kegeles L, Javitt D, Kantrowitz J, Wall MM, Corcoran CM, Schobel SA, Small SA. Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention. Mol Psychiatry. 2018;23(8):1764-72. Epub 20180109. doi: 10.1038/mp.2017.249. PubMed PMID: 29311665; PMCID: PMC6037569.
187. Heckers S, Konradi C. Hippocampal Pathology in Schizophrenia. Current Topics in Behavioral Neurosciences: Springer Berlin Heidelberg; 2010. p. 529-53.
188. Seidman LJ, Pantelis C, Keshavan MS, Faraone SV, Goldstein JM, Horton NJ, Makris N, Peter F, Caviness VS, Tsuang MT. A Review and New Report of Medial Temporal Lobe Dysfunction as a Vulnerability Indicator for Schizophrenia: A Magnetic Resonance Imaging Morphometric Family Study of the Parahippocampal Gyrus. Schizophrenia Bulletin. 2003;29(4):803-30. doi: 10.1093/oxfordjournals.schbul.a007048.
189. Sim K, DeWitt I, Ditman T, Zalesak M, Greenhouse I, Goff D, Weiss AP, Heckers S. Hippocampal and parahippocampal volumes in schizophrenia: a structural MRI study. Schizophr Bull. 2006;32(2):332-40. Epub 20051130. doi: 10.1093/schbul/sbj030. PubMed PMID: 16319377; PMCID: PMC2632210.
190. Karnik-Henry MS, Wang L, Barch DM, Harms MP, Campanella C, Csernansky JG. Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblings. Schizophrenia Research. 2012;138(2-3):128-35. doi: 10.1016/j.schres.2012.03.015.
191. Makhdoum RM, Alahmadi AAS. Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks. Diagnostics (Basel). 2025;15(15):1955. Epub 20250804. doi: 10.3390/diagnostics15151955. PubMed PMID: 40804922; PMCID: PMC12345939.
192. Libby LA, Yonelinas AP, Ranganath C, Ragland JD. Recollection and familiarity in schizophrenia: a quantitative review. Biol Psychiatry. 2013;73(10):944-50. Epub 20121214. doi: 10.1016/j.biopsych.2012.10.027. PubMed PMID: 23245761; PMCID: PMC3609900.
193. Murray EA, Bussey TJ, Saksida LM. Visual perception and memory: A new view of medial temporal lobe function in primates and rodents. Annu Rev Neurosci. 2007; 30:99–122. Doi:10.1146/annurev.neuro.29.051605.113046.