‘’TargetingFemale germline stem cells (FGSCs) in premature ovarian insufficiency(POI) /women with postponement of fertility & following therapy of malignant tumors to attain successful reproductive outcomes-A narrative review’’
Main Article Content
Abstract
In the arena of reproductive medicine, postponement of ovarian aging and perpetuating fertility in cancer patients have long been believed tobe main botherations in addition to continued efforts have beenput in. Female germline stem cells (FGSCs) have been illustrated to cause healing of aging or injured ovarian structures as well as result in restoration of i) ovarian reproductive, along with ii) endocrine working. With their i) limitless proliferation in addition to ii) guided differentiation into oocytes, iii) FGSCs yield innovative enthusiasm to patients with i) ovarian insufficiency, ii) malignant tumors, and iii) others who require fertility preservation. Previously we had reviewed exhaustively etiopathogenesis of premature ovarian insufficiency(POI)/diminished ovarian reserve(DOR) and the manner manipulating signaling pathwayshelped in associated generation of early/ primordial follicles enhanced ART outcomes in POI&DOR patients. Further we thoroughly reviewed part of stem cells inclusive of very small embryonic-like stem cells (VSELs) in oncofertility/ part of silent information regulator 1(Sirt1) signalling in improvement of escalating oocyte quality in women presenting with advanced maternal age. In this review, we debut the part of FGSCs in i) ovarian fertility preservation ii) regenerative healing, highlighting the controlling pathways of FGSCs in resulting in restoration of ovarian working.We detail the distinct benefits of FGSCs in infertility therapy, inclusive of i) fertility preservation, ii) animal gene editing, and, iii) regenerative medicine. This objective of our article is yielding innovative research to gather understanding regarding advancement of the clinical translation of FGSCs by evaluating them from plethora of viewpoints, for instance i) origin, ii) controlling, along with iii) implementation.
Keywords:
Female germline stem cells (FGSCs); ovarian insufficiency; malignant tumors; postponement of ovarian aging
Article Details
How to Cite
KAUR, Dr Kulvinder Kochar; ALLAHBADIA, DR Gautam; SINGH, DR Mandeep.
‘’TargetingFemale germline stem cells (FGSCs) in premature ovarian insufficiency(POI) /women with postponement of fertility & following therapy of malignant tumors to attain successful reproductive outcomes-A narrative review’’.
Medical Research Archives, [S.l.], v. 14, n. 3, mar. 2026.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/7290>. Date accessed: 06 apr. 2026.
doi: https://doi.org/10.18103/mra.v14i3.7290.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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