Abstract
In the arena of reproductive medicine, postponement of ovarian aging and perpetuating fertility in cancer patients have long been believed tobe main botherations in addition to continued efforts have beenput in. Female germline stem cells (FGSCs) have been illustrated to cause healing of aging or injured ovarian structures as well as result in restoration of i) ovarian reproductive, along with ii) endocrine working. With their i) limitless proliferation in addition to ii) guided differentiation into oocytes, iii) FGSCs yield innovative enthusiasm to patients with i) ovarian insufficiency, ii) malignant tumors, and iii) others who require fertility preservation. Previously we had reviewed exhaustively etiopathogenesis of premature ovarian insufficiency(POI)/diminished ovarian reserve(DOR) and the manner manipulating signaling pathwayshelped in associated generation of early/ primordial follicles enhanced ART outcomes in POI&DOR patients. Further we thoroughly reviewed part of stem cells inclusive of very small embryonic-like stem cells (VSELs) in oncofertility/ part of silent information regulator 1(Sirt1) signalling in improvement of escalating oocyte quality in women presenting with advanced maternal age. In this review, we debut the part of FGSCs in i) ovarian fertility preservation ii) regenerative healing, highlighting the controlling pathways of FGSCs in resulting in restoration of ovarian working.We detail the distinct benefits of FGSCs in infertility therapy, inclusive of i) fertility preservation, ii) animal gene editing, and, iii) regenerative medicine. This objective of our article is yielding innovative research to gather understanding regarding advancement of the clinical translation of FGSCs by evaluating them from plethora of viewpoints, for instance i) origin, ii) controlling, along with iii) implementation.