Can a liver which is exposed to drugs and alcohol be supported from eating herbal remedies including seeds from rose-hip?
Main Article Content
Abstract
Background: Certain plants have been claimed to offer some kind of liver protection, often documented as a decline in the liver enzyme amino transferase. The intension of this paper was to outline such plants and to possibly add a new plant Rose-hip (rosa-canina L) to the list.
Methods: Ten healthy middle-aged volunteers equally represented by both sexes were included in an open study where 20 gram of powdered seeds from rose-hip was treated, daily, for three month. Amino transferase, lactate dehydrogenase, C-reactive protein, cholesterol fractions and glucose metabolism including body weight was tested initial and after three month of treatment.
Results: There was statistically significant declines in amino transferase and C-reactive protein and an improvement of HDL-cholesterol as the result of three month treatment. All other parameters remained unchanged.
Conclusion: The present data show that powdered seeds from rose-hip, when treated for three month, can reduce the liver enzyme amino transferase and work anti-inflammatory. The present data suggest that seeds from rose-hip may protect the liver.
Article Details
How to Cite
WINTHER, Kaj.
Can a liver which is exposed to drugs and alcohol be supported from eating herbal remedies including seeds from rose-hip?.
Medical Research Archives, [S.l.], v. 14, n. 5, may 2026.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/7436>. Date accessed: 02 june 2026.
doi: https://doi.org/10.18103/mra.v14i5.7436.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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3. Mirza N. Paracetamol-Induced Hepatotoxicity. 2022; DOI: 10.5772/intechopen.104729
4. Bessone F. Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage? World J Gastroenterol; 16(45):5651-5661. Doi: 10.3748/wjg.v16.i45.5651
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7. Detcheverry F, Mianoor Z, Senthil S, Narayanan S, Badhwar A. Glutathione level variation in brain and blood in healthy aging and Alzheimer`s disease continuum: A Systematic review. Alzheimer`s and Dementia. 2023; 19:S17 / e078506. https://doi.org/10.1002/alz.078506
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10. Patel J, Roy H, Chintamaneni PK, Patel R, Bohara R. Advanced Strategies in Enhancing the hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics and Mechanistic Insight. ACS Biomater. Sci. Eng. 2025; 11(5): 2528-2549. hhtps://doi.org/10.101021/acsbiomaterials.5c00004
11. Shahparan IS, Reyda RN, Qais N. Medical herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review. Heliyon. 2024; 10: e25340. https://doi.org/10.1016/j.heliyon.2024.e25340
12. Amini MR, Sheikhhossein F, Talebyan A, Bazshahi E, Djafari F, Hekmatdoost A. Effects of Artichoke Supplementation on liver Enzymes: A systematic Review and Meta-Analysis of Randomized Controlled Trials. Clin Nutr Res. 2022;11(3):228-239. https://doi.org/10.7762/cnr.2022.11.3.228
13. Fateh HL, Rashid SA, Muhammad SS, Al-Jaf SH, Ali AM. Comparing effects of beetroot juice and Mediterranean diet on liver enzymes and sonographic appearance in patients with non-alcoholic fatty liver disease: a randomized controlled trial. Frontiers in Nutrition. Published 17. August 2023; Doi: 10.3389/fnut.2023.1181706
14. Scott L. Fourteen Natural Herbs That Promotes Liver Health and Vitality. Foodie Heaven. Published June 21; 2025: https://foodie-haven.com/14-natural-herbs-that-promote-liver-health
15. Mancak M, Altintas Y, Balaban Y, Caliskan UK. Evidence-based herbal treatments in liver diseases. Hepatology Forum. 2024;5:50-60. Doi:10.14744/hf.2022.2022.0052
16. Lustrup DC, Winther K. Rose-hip as a Nutraceutical. Medical Plants (Editor: S Kumar), Chapter 18, 2022; Print ISBN: 978-1-80356-032-8. http://dx.doi.org/10.5772/intechopen.98097
17. Winther K, Warholm L, Campbel-Tofte J, Marstrand K. Effect of Rosa canina L (Rose-hip) on cold during winter season in a middleclass population: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine. 2018;334-341. https://doi.org/10.1016/J.hermed.2018.04.003
18. Winther K, Apel K, Thamsborg G. A powder made from seeds and shells of a rose-hip subspecies (rosa-canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34:302-308. Doi: 10.1080/03009740510018624
19. Marstrand K, Warholm L, Pedersen F, Winther K. Dose-Dependent Impact of Rose-Hip Powder in Patients Suffering from Osteoarthritis of the Hip and or Knee – A Double-blind, Randomized, Placebo Controlled, Parallel Group, Phase III Study. Int J Complement Alt Med. 2017; 6(6):00210. DOI: 10.15406/ijcam.2017.07.00210
20. Willich SN, Rossnagel K, Roll S, Wagner A, Mune O, Erlendson J, Kharazmi A, Sörensen H, Winther K. Rose-hip herbal remedy in patients with rheumatoid arthritis – a randomized controlled trial. Phytomedicine. 2010; 17: 87-93. Doi: 10.1016/j.phytomed.2009.09.003
21. Kharazmi A, Winther K. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo. Inflammopharmacology. 1999; 7(4):377-386
22. Rein E, Kharazmi A, Winther K. A herbal remedy, Hyben Vital (stand. Powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis – a double-blind, placebo-controlled, randomized trial. Phytomedicine 2004; 11: 383-391. Doi:10.1016/j.phymed. 2004.01.001
23. Martirosyan D, Min S-Y, Xie C, Yan M, Bashmakov A et al. The effect of rose-hip on experimental anti-GBM glomerulonephritis in systemic lupus erythematosus murine models. Functional food Science 2021; 1(12):86-96
24. Halvorsen BL, Holte K, Myhrstad MCW, et al. A systematic Screening of Total Antioxidants in Dietary Plants. J. Nutr. 2002;132:461-471
25. Winther K, Vinther ASV, Campbel-Tofte J. Bioactive ingredients of rose hips (Rosa canina L) with special reference to antioxidative and anti-inflammatory properties: in vivo studies. Botanics: Targets and Therapy. 2016; 6:1-13.
26. Nagatomo A, Nishida N, Fukuhara I et al. Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2015; 8: 147-156. https.//dx.doi.org/10.2147/DMSO.578623
27. Winther K. Can a salad containing different herbs replace rescue medication in osteoarthritis? Int J Alt Med. 2024;17(4):199-200. DOI:10.15406/ijcam.2024.17.00703
2. Tramadol-Livertox-NCBI Bookshelf. Bookshelf ID: NBK548235. PMID: 31643560. November 24, 2020. https://www.ncbi.nlm.nih.gov/books/NBK54825/
3. Mirza N. Paracetamol-Induced Hepatotoxicity. 2022; DOI: 10.5772/intechopen.104729
4. Bessone F. Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage? World J Gastroenterol; 16(45):5651-5661. Doi: 10.3748/wjg.v16.i45.5651
5. Elmanama AA, Tayyem NESA, Essawaf HN, Hmaid IM. Tramadol-Induced Liver and Kidney Toxicity among Abusers in Gaza Strip, Palestine. JJBS 2015; 8(2):133-137
6. Le Couteur DG, Ngu MC, Hunt NJ, Brandon AE, Simpson SJ, Cogger VC. Liver ageing and disease (a review). Nature Reviews Gastroenterology and Hepatology. 2025; 680-695. https://doi.org/10.1038/s41575-025-01099-z
7. Detcheverry F, Mianoor Z, Senthil S, Narayanan S, Badhwar A. Glutathione level variation in brain and blood in healthy aging and Alzheimer`s disease continuum: A Systematic review. Alzheimer`s and Dementia. 2023; 19:S17 / e078506. https://doi.org/10.1002/alz.078506
8. Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr 2011;94:847-853. Doi: 10.3945/ajen.110.003483
9. Laoenna D. Gluthatione and gluthatione-dependent enzymes: From biochemistry to gerontology and successful aging.Ageing Research Reviews 92, 2023;102066 https://doi.org/10.1016/j.arr.2023.102066
10. Patel J, Roy H, Chintamaneni PK, Patel R, Bohara R. Advanced Strategies in Enhancing the hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics and Mechanistic Insight. ACS Biomater. Sci. Eng. 2025; 11(5): 2528-2549. hhtps://doi.org/10.101021/acsbiomaterials.5c00004
11. Shahparan IS, Reyda RN, Qais N. Medical herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review. Heliyon. 2024; 10: e25340. https://doi.org/10.1016/j.heliyon.2024.e25340
12. Amini MR, Sheikhhossein F, Talebyan A, Bazshahi E, Djafari F, Hekmatdoost A. Effects of Artichoke Supplementation on liver Enzymes: A systematic Review and Meta-Analysis of Randomized Controlled Trials. Clin Nutr Res. 2022;11(3):228-239. https://doi.org/10.7762/cnr.2022.11.3.228
13. Fateh HL, Rashid SA, Muhammad SS, Al-Jaf SH, Ali AM. Comparing effects of beetroot juice and Mediterranean diet on liver enzymes and sonographic appearance in patients with non-alcoholic fatty liver disease: a randomized controlled trial. Frontiers in Nutrition. Published 17. August 2023; Doi: 10.3389/fnut.2023.1181706
14. Scott L. Fourteen Natural Herbs That Promotes Liver Health and Vitality. Foodie Heaven. Published June 21; 2025: https://foodie-haven.com/14-natural-herbs-that-promote-liver-health
15. Mancak M, Altintas Y, Balaban Y, Caliskan UK. Evidence-based herbal treatments in liver diseases. Hepatology Forum. 2024;5:50-60. Doi:10.14744/hf.2022.2022.0052
16. Lustrup DC, Winther K. Rose-hip as a Nutraceutical. Medical Plants (Editor: S Kumar), Chapter 18, 2022; Print ISBN: 978-1-80356-032-8. http://dx.doi.org/10.5772/intechopen.98097
17. Winther K, Warholm L, Campbel-Tofte J, Marstrand K. Effect of Rosa canina L (Rose-hip) on cold during winter season in a middleclass population: A randomized, double-blind, placebo-controlled trial. Journal of Herbal Medicine. 2018;334-341. https://doi.org/10.1016/J.hermed.2018.04.003
18. Winther K, Apel K, Thamsborg G. A powder made from seeds and shells of a rose-hip subspecies (rosa-canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34:302-308. Doi: 10.1080/03009740510018624
19. Marstrand K, Warholm L, Pedersen F, Winther K. Dose-Dependent Impact of Rose-Hip Powder in Patients Suffering from Osteoarthritis of the Hip and or Knee – A Double-blind, Randomized, Placebo Controlled, Parallel Group, Phase III Study. Int J Complement Alt Med. 2017; 6(6):00210. DOI: 10.15406/ijcam.2017.07.00210
20. Willich SN, Rossnagel K, Roll S, Wagner A, Mune O, Erlendson J, Kharazmi A, Sörensen H, Winther K. Rose-hip herbal remedy in patients with rheumatoid arthritis – a randomized controlled trial. Phytomedicine. 2010; 17: 87-93. Doi: 10.1016/j.phytomed.2009.09.003
21. Kharazmi A, Winther K. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo. Inflammopharmacology. 1999; 7(4):377-386
22. Rein E, Kharazmi A, Winther K. A herbal remedy, Hyben Vital (stand. Powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis – a double-blind, placebo-controlled, randomized trial. Phytomedicine 2004; 11: 383-391. Doi:10.1016/j.phymed. 2004.01.001
23. Martirosyan D, Min S-Y, Xie C, Yan M, Bashmakov A et al. The effect of rose-hip on experimental anti-GBM glomerulonephritis in systemic lupus erythematosus murine models. Functional food Science 2021; 1(12):86-96
24. Halvorsen BL, Holte K, Myhrstad MCW, et al. A systematic Screening of Total Antioxidants in Dietary Plants. J. Nutr. 2002;132:461-471
25. Winther K, Vinther ASV, Campbel-Tofte J. Bioactive ingredients of rose hips (Rosa canina L) with special reference to antioxidative and anti-inflammatory properties: in vivo studies. Botanics: Targets and Therapy. 2016; 6:1-13.
26. Nagatomo A, Nishida N, Fukuhara I et al. Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2015; 8: 147-156. https.//dx.doi.org/10.2147/DMSO.578623
27. Winther K. Can a salad containing different herbs replace rescue medication in osteoarthritis? Int J Alt Med. 2024;17(4):199-200. DOI:10.15406/ijcam.2024.17.00703