Abstract
Although scar formation following vocal fold surgery for benign diseases is rare, it has disastrous results. Platelet-rich fibrin has positive effects on wound healing and has been used in various disciplines for some time. This study aimed to evaluate the potential effects of platelet-rich fibrin on wound healing in the animal model's vocal folds.
Fourteen Wistar albino rats were included in the study. Six of them formed the fibrin-rich platelet group, and another six comprised the wound group. Two rats were monitored without any surgical intervention. Rats in the first group received fibrin-rich platelets after a surgical wound was created. The second group was observed without platelet-rich fibrin. Histopathological examination was performed on all vocal folds at the end of the second week. Inflammation in the epithelial layer and lamina propria, as well as vascular proliferation, was evaluated.
In the platelet-rich fibrin group, 33.4% of vocal folds showed inflammation, and 50% exhibited vascular proliferation. On the other hand, the second group had inflammation in 66.6% of rats and vascular proliferation in 83.3% of rats. The first group showed no inflammation in the lamina propria in 16.7% of cases, whereas the second group had inflammation in 100% of cases.
Platelet-rich fibrin may have some positive effects on vocal fold healing, but more comprehensive research is needed to confirm this.