Mutations in the CXCR4 gene cause a population shift in the feline lymphoma cell line 3201 surviving feline immunodeficiency virus infection

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Tadafumi Tochikura Kenji Motokawa Yuko Naito Kinjiro Morimoto

Abstract

The feline 3201-S cell line was established from original 3201 cell populations that survived productive infection of feline thymic lymphoma 3201 cells with feline immunodeficiency virus (FIV).  The 3201-S cells expressing a mutated CXCR4 are unresponsive to the CXCR4 ligand SDF-1α, and are refractory to FIV reinfection.  In this mini-review, possible mechanisms of how the 3201-S cells could restrict FIV infection and could not respond to SDF-1α are described and discussed.

Article Details

How to Cite
TOCHIKURA, Tadafumi et al. Mutations in the CXCR4 gene cause a population shift in the feline lymphoma cell line 3201 surviving feline immunodeficiency virus infection. Medical Research Archives, [S.l.], v. 5, n. 1, jan. 2017. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/930>. Date accessed: 29 mar. 2024.
Keywords
Feline immunodeficiency virus; 3201; 3201-S; CXCR4; Sequence analysis
Section
Research Articles

References

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