Mutations in the CXCR4 gene cause a population shift in the feline lymphoma cell line 3201 surviving feline immunodeficiency virus infection
Main Article Content
Abstract
The feline 3201-S cell line was established from original 3201 cell populations that survived productive infection of feline thymic lymphoma 3201 cells with feline immunodeficiency virus (FIV). The 3201-S cells expressing a mutated CXCR4 are unresponsive to the CXCR4 ligand SDF-1α, and are refractory to FIV reinfection. In this mini-review, possible mechanisms of how the 3201-S cells could restrict FIV infection and could not respond to SDF-1α are described and discussed.
Article Details
How to Cite
TOCHIKURA, Tadafumi et al.
Mutations in the CXCR4 gene cause a population shift in the feline lymphoma cell line 3201 surviving feline immunodeficiency virus infection.
Medical Research Archives, [S.l.], v. 5, n. 1, jan. 2017.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/930>. Date accessed: 26 dec. 2024.
Keywords
Feline immunodeficiency virus; 3201; 3201-S; CXCR4; Sequence analysis
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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Willett BJ, Adema K, Heveker N, et al. The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus. J Virol. 1998 ; 72(8) : 6475-6481. ［PubMed:9658090］
Willett BJ, Picard L, Hosie MJ, et al. Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. J Virol. 1997;71(9): 6407-6415. ［PubMed:9261358］
Brunner D, Pedersen NC. Infection of peritoneal macrophages in vitro and in vivo with feline immunodeficiency virus. J Virol. 1989 ; 63(12) : 5483 - 5488. ［PubMed:2479773］
de Parseval A, Chatterji U, Sun P, et al. Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor. Proc Natl Acad Sci USA. 2004 ; 101(35) : 13044 - 13049. ［PubMed:15326292］
Endo Y, Goto Y, Nishimura Y,et al. Inhibitory effect of stromal cell derived factor-1 on the replication of divergent strains of feline immunodeficiency virus in a feline T-lymphoid cell line. Vet Immunol Immunopathol. 2000 ; 74 (3-4): 303 -314. ［PubMed:10802296］
Hohdatsu T, Hirabayashi H, Motokawa K, et al. Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A,B and D classified on the basis of the env gene V3-V5 sequence. J Gen Virol. 1996 ; 77(1) : 93 - 100.［PubMed:8558132］
Hohdatsu T, Motokawa K, Usami M, et al. Genetic subtyping and epidemiological study of feline immunodeficiency virus by nested polymerase chain reaction-restriction fragment length polymorphism analysis of the gag gene. J Virol Methods. 1998 ; 70(1) : 107 - 111.［PubMed:9506819］
Hosie MJ, Broere N, Hesselgesser J.,et al. Modulation of ｆeline Immunodeficiency virus Infection by stromal cell-derived factor. J Virol. 1998 ; 72(3) : 2097 - 2104.［PubMed:9499065］
Ichiyama K, Yokoyama-Kumakura S, Tanaka Y, et al. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc Natl Acad Sci USA. 2003 ; 100(7) : 4185 - 4190.［PubMed:12642669］
Juarez J, Bendall L, Bradstock K. Chemokines and their receptors as therapeutic targets : the role of the SDF-1/CXCR4 axis. Curr Pharm Des. 2004;10(11):1245-1259. ［PubMed:15078139］
Letvin NL, Daniel MD, Sehgal PK, et al. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science. 1985 ; 230(4721) : 71 - 73.［PubMed:2412295］
Levy JA. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 1993 ; 57(1) : 183 - 289.［PubMed:8464405］
Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol. 1994 ; 12 : 593 - 633.［PubMed:8011292］
Pedersen NC, Ho E, Brown ML, et al. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science. 1987 ; 235(4790) : 790 - 793.［PubMed:3643650］
Pedersen NC, Yamamoto JK, Ishida T, et al. Feline immunodeficiency virus infection. Vet Immunol Immunopathol. 1989 ; 21(1) : 111 - 129.［PubMed:2549690］
Shimojima M, Miyazawa T, Ikeda Y, et al. Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science. 2004 ; 303(5661) : 1192 - 1195. ［PubMed:14976315］
Sloane AJ, Raso V, Dimitrov DS, et al. Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1 alpha responses. Immunol Cell Biol. 2005 ; 83(2) : 129 - 143. ［PubMed:15748209］
Snyder HW Jr, Hardy WD Jr, Zuckerman EE, et al. Characterisation of a ttumor-specific antigen on the surface of feline lymphosarcoma cells. Nature. 1978 ; 275(5681) : 656- - 658. ［PubMed:212681］
Tochikura TS, Hayes KA, Cheney CM, et al. In vitro replication and cytopathogenicity of the feline immunodeficiency virus for feline T4 thymic lymphoma 3201 cells. Virology. 1990 ; 179(1) : 492-497.［PubMed:1699355］
Tochikura TS, Morimoto K. Sequence analysis of the CXCR4 gene derived from cells surviving feline lentivirus infection. Arch Virol. 2014 ; 159(6) : 1511 - 1513.［PubMed:24370967］
Tochikura TS, Motokawa K, Naito Y, et al. Differential CXCR4 expression and function in subpopulations of the feline lymphoma cell line 3201 susceptible to feline immunodeficiency virus. J Feline Med Surg. 2010 ; 12(4) : 269–277. ［PubMed:19896878］
Willett BJ, Adema K, Heveker N, et al. The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus. J Virol. 1998 ; 72(8) : 6475-6481. ［PubMed:9658090］
Willett BJ, Picard L, Hosie MJ, et al. Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. J Virol. 1997;71(9): 6407-6415. ［PubMed:9261358］