Do immune cells regulate mural cell behaviors in injured arteries?
Main Article Content
Abstract
Current understanding regarding the involvement of immune cells in the maintenance of vascular structures is limited. Recently, it was shown that T cells play crucial roles for normalization of tumor vessels by promoting pericyte coverage. In our previous study, where mice were subjected to wire injury (WI) operations to remove endothelial layers and induce arterial stenosis, we accidentally found that immunodificient mice were resistant to the development of injury-associated stenosis. WI-operated arteries of anti-asialo GM1 monoclonal antibody-treated mice retained intact morphologies: SMCs stayed in tunica media without migrating into tunica intima to form neointima. In SCID mice, tunica media turned into acellular substance as a result of massive escape of SMCs from injured arteries to extravascular spaces. In this review, we discuss possible involvements of immune cells in regulating the behaviors of mural cells in injured arteries.
Article Details
How to Cite
NAKAHARA, Masako et al.
Do immune cells regulate mural cell behaviors in injured arteries?.
Medical Research Archives, [S.l.], v. 5, n. 8, aug. 2017.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1475>. Date accessed: 15 dec. 2024.
Keywords
T cells, NK cells, mural cells, vascular injury, asialo GM1, RGS5
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
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Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature 544: 250-254, 2017.
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