A simple method for evaluation of aqueous humor dynamics “A weight on-off test” in patients with glaucom

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Hiroshi Ohguro
Department of Ophthalmology, Sapporo Medical University School of Medicine
Megumi Watanabe
Department of Ophthalmology, Sapporo Medical University School of Medicine
Shuichiro Inatomi
Department of Ophthalmology, Sapporo Medical University School of Medicine
Kazushi Umeda
Department of Ophthalmology, Sapporo Medical University School of Medicine
Ikuyo Ohguro
Department of Ophthalmology, Sapporo Medical University School of Medicine

Abstract

Purpose:To evaluate aqueous humor (AH) dynamics in patients with glaucoma through a newly developed method termed the “Weight on-off test”

Methods: Patients: primary open angle glaucoma (POAG)(n=124), primary angle closure glaucoma (n=16), Pseudoexfoliation syndrome(n=17), or senile cataract (n=93) without other eye diseases. For evaluation of AH dynamics, a 50 g weight was placed onto the eye of a subject in a supine position for 5 min and then removed. Intraocular pressure (IOP) was measured before and immediately after removal, and thereafter every minute until IOP returned to baseline. Based upon IOP changes (decreases during the weight on and recovery after removal), we defined AH outflow resistance: IOP drop rate (IOPdrop) (%) = (P0-Pe) – (P5-Pe) / (P0-Pe) x 100 (P0: IOP at baseline, Pe: assumed episcleral venous pressure, P5: IOP at 5 min) and AH outflow resistance index (Raq out)= 100 - IOP drop, and AH production: IOP recovery time (IOPrec) (min) reached to baseline IOP, and AH production index (Paq) was an IOP increase rate during the IOPrec by least squares method.

Results:AH outflow resistance was significantly higher in glaucoma subjects than the control. AH production in glaucoma subjects was slightly increased compared to that in control. In POAG, prostaglandin-analogues (PG) caused a significant delay of AH production (IOPrec).

Conclusions: The current data suggests that a “Weight on-off test” may be simple and useful for estimating AH dynamics in patients with glaucoma and provides a better understanding of glaucoma etiology as well as its pharmacology.

Article Details

How to Cite
OHGURO, Hiroshi et al. A simple method for evaluation of aqueous humor dynamics “A weight on-off test” in patients with glaucom. Medical Research Archives, [S.l.], n. 3, june 2015. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/227>. Date accessed: 15 nov. 2024.
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Keywords
aqueous humor ; glaucoma ; intraocular pressure ; tonography
Issue
No 3 (2015)
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

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