Alternatives to heparin anticoagulation for cardiopulmonary bypass and extracorporeal membrane oxygenation

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Sanjana A. Malviya, MD MBA Emily G Bruner, MD Alexandra Belfar, MD Yi Deng, MD

Abstract

Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are both mechanical circulatory support technologies that augment the native heart and/or lung function. They involve drainage and reinfusion of blood while performing extracorporeal gas exchange. 1 In both devices, contact between patient blood and the non-endothelialized surface of the circuit triggers an inflammatory response and pro-coagulation cascade. 2–5 As a result, prophylactic anticoagulation is integral to prevent catastrophic thrombosis of the circuitry. In rare instances, there exist contraindications to heparin use, necessitating alternative management strategies. 6 In this review, we will examine heparin contraindications in mechanical circulatory support and summarize alternative approaches to anticoagulation in these circumstances.

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How to Cite
MALVIYA, Sanjana A. et al. Alternatives to heparin anticoagulation for cardiopulmonary bypass and extracorporeal membrane oxygenation. Medical Research Archives, [S.l.], v. 9, n. 8, aug. 2021. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/2528>. Date accessed: 31 jan. 2023. doi: https://doi.org/10.18103/mra.v9i8.2528.
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Research Articles