Molecular Features and Targeted Therapy in KRAS wild-type Pancreatic Cancer
Main Article Content
Abstract
KRAS mutation is the major oncogenic event in approximately 90% of pancreatic ductal adenocarcinomas. The subset of patients with KRAS wild-type pancreatic ductal adenocarcinomas represent a distinct subgroup with a higher frequency of actionable genomic alterations. In this review article, we aim at exploring the more frequent molecular alterations found among KRAS wild-type pancreatic ductal adenocarcinomas, their prognostic implications, as well as the potential targetable therapeutic options beyond cytotoxic chemotherapy for this unique subset of patients.
Keywords:
pancreatic cancer, KRAS wild-type, targeted therapy
Article Details
How to Cite
MATHIAS-MACHADO, Maria Cecília et al.
Molecular Features and Targeted Therapy in KRAS wild-type Pancreatic Cancer.
Medical Research Archives, [S.l.], v. 11, n. 4, apr. 2023.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/3764>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.18103/mra.v11i4.3764.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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