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01 · ABSTRACT

Abstract

Addiction, albeit some disbelievers like Mark Lewis [1], is a chronic, relapsing brain disease, resulting in unwanted loss of control over both substance and non- substance behavioral addictions leading to serious adverse consequences [2]. Addiction scientists and clinicians face an incredible challenge in combatting the current opioid and alcohol use disorder (AUD) pandemic throughout the world. Provisional data from the Centers for Disease Control and Prevention (CDC) shows that from July 2021-2022, over 100,000 individuals living in the United States (US) died from a drug overdose, and 77,237 of those deaths were related to opioid use [3]. This number is expected to rise, and according to the US Surgeon General it is highly conceivable that by 2025 approximately 165,000 Americans will die from an opioid overdose. Alcohol abuse, according to data from the World Health Organization (WHO), results in 3 million deaths worldwide every year, which represents 5.3% of all deaths globally [4].

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02 · PUBLICATION RECORD

Article details

JournalMedical Research Archives
IssueVol 11 No 8 (2023): August Issue, Vol.11, Issue 8
SectionResearch Articles
Published14 September 2023
DOI10.18103/mra.v11i8.4211
ISSN2375-1924
03 · RIGHTS & REUSE

Rights & reuse

This article is published under a Creative Commons Attribution License (CC BY 3.0) and may be shared or distributed by anyone as long as attribution is given to the journal.

Authors & affiliations

KB

Kenneth Blum

The Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX., USA.; Division of Addiction Research & Education, Center for Sports, Exercise & Psychiatry, Western University Health Sciences, Pomona, CA., USA.; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.; Department of Psychiatry, School of Medicine, University of Vermont, Burlington, VT.,USA.; Department of Psychiatry, Wright State University Boonshoft School of Medicine and Dayton VA Medical Centre, Dayton, OH, USA.; Division of Nutrigenomics Research, TranspliceGen Therapeutics, Inc., Austin, Tx., 78701, USA; Department of Nutrigenomic Research, Victory Nutrition International, Inc., Bonita Springs, FL, USA.; Division of Personalized Medicine, Cross-Cultural Research and Educational Institute, San Clemente, CA., USA; Sunder Foundation, Palm Springs, CA, USA; Department of Molecular Biology and Adelson School of Medicine, Ariel University, Ariel, Israel.

MG

Mark S Gold

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., USA.

JC

Jean Lud Cadet

Molecular Neuropsychiatry Research Branch, National Insti-tute on Drug Abuse, National Institutes of Health, Bethesda, MD., USA

MG

Marjorie C. Gondre-Lewis

Neuropsychopharmacology Laboratory, Department of Anatomy, Howard University College of Medicine, Washing-ton, DC., USA.

TM

Thomas McLaughlin

Division of Nutrigenomics Re-search, TranspliceGen Thera-peutics, Inc., Austin, Tx., 78701, USA

IE

Igor Elman

Center for Pain and the Brain (P.A.I.N Group), Department of Anesthesiology, Critical Care & Pain Medicine, Boston Chil-dren's Hospital, Boston, MA., USA.

BC

B. Paul Carney

Division Pediatric Neurology, University of Missouri ,School of Medicine, Columbia, MO., USA

RC

Rene Cortese

Department of Child Health – Child Health Research Institute, & Department of Obstetrics, Gynecology and Women’s Health School of Medicine, Uni-versity of Missouri, MO., USA.

TA

Tomilowo Abijo

Neuropsychopharmacology Laboratory, Department of Anatomy, Howard University College of Medicine, Washing-ton, DC., USA.

DB

Debasis Bagchi

Department of Pharmaceutical Sciences, Texas Southern Uni-versity College of Pharmacy and Health Sciences, Houston, TX, USA

JG

John Giordano

Division of Personalized Mental Illness Treatment & Research, Ketamine Infusion Clinics of South Florida, Pompano Beach, Fl., USA

DB

David Baron

Institute of Psychology, ELTE Eötvös Loránd University, Bu-dapest, Hungary.

PT

Panayotis K Thanos

Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.; Department of Psychology, State University of New York at Buffalo, Buffalo, NY 14203, USA.

DS

Diwanshu Soni

College of Osteopathic Medi-cine of the Pacific, Western University of Health Sciences, Pomona, CA., USA.

MM

Milan T. Makale

Department of Radiation Medi-cine and Applied Sciences, UC San Diego, 3855 Health Sci-ences Drive, La Jolla, CA 92093-0819, USA.

MM

Miles Makale

Department of Psychology, UC San Diego, Health Sciences Drive, La Jolla, CA, 92093, USA

NJ

Nicole Jafari

Department of Human Devel-opment, California State Uni-versity at long Beach, Long Beach, CA., USA ; Division of Personalized Medi-cine, Cross-Cultural Research and Educational Institute, San Clemente, CA., USA

KS

Keerthy Sunder

Department of Psychiatry, Me-nifee Global Medical Center, Palm Desert, CA., USA; Sunder Foundation, Palm Springs, CA, USA

FZ

Foojan Zeine

Awareness Integration Institute, San Clemente, CA., USA.; Department of Health Science, California State University at Long Beach, Long Beach, CA., USA.

MC

Mauro Ceccanti

Società Italiana per il Tratta-mento dell’Alcolismo e le sue Complicanze (SITAC), ASL Ro-ma1, Sapienza University of Rome, Rome, Italy

AB

Abdalla Bowirrat

Department of Molecular Biol-ogy and Adelson School of Medicine, Ariel University, Ariel, Israel.

RB

Rajendra D. Badgaiyan

Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX., USA.; Department of Psychiatry, Mt Sinai University School of Medicine, New York, NY., USA

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