Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case

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Luis Ricardo Willians Marthelena Acosta Marin, MD

Abstract

The case of a 13-year-old male patient is presented, with a history of Bilateral Retinoblastoma since he was 2 years old, undergoing enucleation of the right eye in June 2007, and salvage of the left eye by chemotherapy and radiotherapy, said patient 11 years after This episode presented metastasis in the distal end of the right radius, performing neoadjuvant treatment and subsequent wide oncological resection with healthy margins of the distal end of the radius plus reconstruction with the proximal end of the ipsilateral fibula and arthrodesis of the wrist. . It is important to point out that distant bone involvement and that of long bones are very few cases reported in the literature, therefore this case was a challenge for diagnosis and treatment, since a retinoblastoma was obtained that metastasized 12 years later. of the enucleation of the eye with the primary tumor and in turn performed it in the long bone (radius), it is emphasized that said patient was followed up free of disease for 2 years after surgery (wrist fusion). Given the limitations of knowledge of the genetics of retinoblastoma metastasis to long bones, not all alterations are currently known. It is considered that a genetic study should be done in patients diagnosed on time.

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How to Cite
WILLIANS, Luis Ricardo; MARIN, Marthelena Acosta. Late and Distant Metastases of Retinoblastoma to Long Bones: A Purpose of a Case. Medical Research Archives, [S.l.], v. 11, n. 8, sep. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4337>. Date accessed: 13 july 2024. doi: https://doi.org/10.18103/mra.v11i8.4337.
Section
Case Reports

References

1. Shields CL, Shields JA. Diagnosis and management of retinoblastoma. Cancer Control. 2004 Sep-Oct;11(5):317-27.
2. Abelairas J, Peralta J, Sánchez E, Gayá F. Introducción al retinoblastoma. Retinoblastoma. En: Fonseca A, Abelairas J, Rodríguez JM, Peralta J. Actualización en cirugía oftálmica pediátrica. Madrid: Tecnimedia editorial S.L; 2000; 265-76.
3. Abramson DH. Retinoblastoma in the 20th Century: past success and future challenges the weisenfeld lecture. Invest Ophthalmol Vis Sci (Rockville, Maryland). 2005 Ago; 46(8): 2684-2691.
4. Ellsworth RM. Orbital retinoblastoma. Transactions of the American Ophthalmological Society. 1974;72:79-88.
5. Bechrakis NE, Bornfeld N, Schuler A, Coupland MBS, Henze G, Foerster MH. Clinipathologic features of retinoblastoma after primary chemoreduction. Arch Ophthalmol 1998; 116: 887-893.
6. Rodriguez-Galindo C, Orbach DB, VanderVeen D. Retinoblastoma. Pediatr Clin North Am. 2015 Feb;62(1):201-23.
7. Abramson DH. Retinoblastoma 1990: diagnosis, treatment and implications. Pediatr Ann 1990; 19:387-95.
8. Castéra L, Sabbagh A, Dehainault C, et al.: MDM2 as a modifier gene in retinoblastoma. J Natl Cancer Inst 102 (23): 1805-8, 2010
9. Jubran RF, Erdreich-Epstein A, Butturini A, Murphree AL, Villablanca JG. Approaches to treatment for extraocular retinoblastoma: Children’s Hospital Los Angeles experience. J Pediatr Hematol Oncol. 2004;26:31–34.
10. Vasudevan V, Cheung MC, Yang R, Zhuge Y, Fischer AC, Koniaris LG, et al. Pediatric solid tumors and second malignancies: characteristics and survival outcomes. J Surg Res. 2010 May 15;160(2):184-9.
11. Leal-Leal C, Flores-Rojo M, Medina-Sansón A, Cerecedo Díaz F, Sánchez-Félix S, González- Ramella, et al. A multicentre report from the Mexican Retinoblastoma Group. Br J Ophthalmol 2004; 88(8):1074-1077.
12. Murphree AL, Munier FL. Retinoblastoma. En: Ryan SJ, editor. Retina [CD-ROM]. Mosby; 1994, vol 1.
13. Greenberg RS, Shuster JL. Epidemiology of cancer in children. Epidemiol Rev 1985;7:22-48.
14. Wang AG, Hsu WM, Hsia WW, Liu JH, Yen MY. Clinicopathologic factors related to metastasis inretinoblastoma. J Pediatr Ophthalmol Strabismus 2001;38(3):166-171.
15. Rodríguez-Galindo C, Wilson MW, Haik BG, Lipson MJ, Cain A, Merchant TE, Kaste S, Pratt CB. Treatment of metastatic retinoblastoma. Ophthalmology 2003;110(6):1237-1240.
16. Kaliki S, Shields CL, Rojanaporn D, et al.: High-risk retinoblastoma based on international classification of retinoblastoma: analysis of 519 enucleated eyes. Ophthalmology 120 (5): 997-1003, 2013.
17. Karcioglu ZA, Al-Mesfer SA, Abboud E, Monzer H.J, Mullaney PB. Workup for metastatic retinoblastoma. Ophthalmology 1997;104(2):307-312.
18. Racher H, Soliman S, Argiropoulos B, et al. Molecular analysis distinguishes metastatic disease from second cancers in patients with retinoblastoma. Cancer Genet. 2016;209:359–363.
19. Beatriz Alvarado-Castillo, Laura Elena Campos-Campos, Astrid Villavicencio-Torres. Características clínicas y metastásicas en retinoblastoma Rev Med Inst Mex Seguro Soc 2009; 47 (2): 151-156
20. Rubenfeld M, Abramson DH, Ellsworth RM, Kitchin FD. Unilateral vs. Bilateral retinoblastoma. Correlations between age at diagnosis and stage of ocular disease. Ophthalmology 1986; 93:1016-9.
21. Arevalo J. Fernando, et al. Retina Medica temas selectos primera edición. Caracas Venezuela, Amolca 2007, capitulo 6: 114-116.
22. Halperin EC, P. C ., Brady LW. Principles and practice of radiation oncology, 5Th edition. Philadelphia: Lippincott Williams and Wilkins, 2008.
23. MacKay CJ, Abramson DH, Ellsworth RM. Metastatic patterns of retinoblastoma. Arch Ophthalmol 1984;102(3):391-396.
24. Antillon F, Esponda JC. Sarcomas por irradiacion de retinoblastomas. An Soc Mex Oftal 1977; 51: 67-74.