Evaluation of Some Biochemical Parameters in Glucose-6-Phosphate Dehydrogenase deficient subjects of Hausa and Fulani ethnics

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Jelani I Abdullahi HL Alhassan AJ Dalhatu MM Dangambo MA Abacha FZ Haruna S Mahmud RI Yandutse MI Hamza HD Abdu R Musa AH


Glucose-6-phosphate dehydrogenase deficiency is a significant public health problem that is implicated in the pathogenesis of a number of common diseases via increased oxidative stress and a decrease in the generation of nitric oxide. There is little information about its impact on some organ, hence the need for this research. This was a case-control study carried out on Hausa and Fulani ethnics in Kano. Heparinized 5 ml venous blood specimen were collected from 140 individuals (70 deficient and 70 control) aged between 18-35 years selected for the study to determine the blood levels of some biochemical parameters using standard methods. There were significant increase in transaminases (p<0.001), but significant decrease concentrations of sodium (p<0.05), chloride (p<0.001), alkaline phosphatase (p<0.001) and total protein (p<0.001) whereas there was no statistically significant difference (p>0.05) in the plasma concentration of albumin, total bilirubin, conjugated bilirubin, urea, creatinine, potassium and bicarbonate ions. Our results demonstrate extremely significantly lower (p<0.001 for all) concentration in glutathione reductase, total antioxidants potential, copper, zinc and non-significant decrease (p>0.05) in manganese level of G-6-PD deficient patients compared to controls, whereas malondialdehyde level showed an increasing trend on contrary. However, there were correlations between G-6-PD activity and oxidative stress markers. The findings of the present study suggest that liver and kidneys functions were not altered among people living with G-6-PD deficiency but induce oxidative stress which is not capable of causing organ impairment.

Keywords: G-6-PD deficiency, oxidative stress, liver, kidneys, Hausa, Fulani, Kano-Nigeria

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I, Jelani et al. Evaluation of Some Biochemical Parameters in Glucose-6-Phosphate Dehydrogenase deficient subjects of Hausa and Fulani ethnics. Medical Research Archives, [S.l.], v. 12, n. 6, june 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5313>. Date accessed: 22 july 2024. doi: https://doi.org/10.18103/mra.v12i6.5313.
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