Abstract
With lifestyles changes, chronic non-communicable diseases are the new pandemic of this century. This includes diabetes, that even if it exists a polygenic genetic predisposition, the effect of epigenetics is more relevant. Among the epigenetic conditions are endocrine disruptors, to which human being have high exposure in daily life, these can damage multiple organs such as the intestinal microbiota, generating toxicity and predisposing to development of the disease. The goal of the article is to discuss the mechanisms of endocrine disruptors that can affect our health, particularly in terms of the development of type 2 diabetes mellitus due to intestinal dysbiosis. Taking in to account that we are in permanent contact to these, directly or indirectly, substances such as pesticides, plastics, medications, sweeteners, among others can be taken as endocrine disruptors.