Histoligical analysis of ridge augmentation with Autologus Dentin graft and Acellular Dermal matrix: A Descriptive Case Report

Article Sidebar

23-Oct-5890.pdf
Published Oct 29, 2024
DOI: https://doi.org/10.18103/mra.v12i10.5820

Downloads

Download data is not yet available.

Submit your own article

Register as an author to reserve your spot in the next issue of the Medical Research Archives.

Author Registration

Join the Society

The European Society of Medicine is more than a professional association. We are a community. Our members work in countries across the globe, yet are united by a common goal: to promote health and health equity, around the world.

Join Europe’s leading medical society and discover the many advantages of membership, including free article publication.

Membership

Main Article Content

Lanka Mahesh, BDS, MBA, PhD
Implantologist, Director- The Specialist Clinic, Private practice, New Delhi, India.
Maurice Salama, DMD
Private practice, Atlanta, Georgia, USA
Sagrika Shukla
MDS (Periodontology), Reader, Dept of Periodontology and Implantology, SGT university, Budhera, Haryana, India
Praful Bali, PhD
MDS, Prosthodontist, Director, Bali Dental Clinic, New Delhi, India
Athreya Rajagopal, PhD
MDS, PhD, Reader, Oral and maxillofacial surgeon, Santosh, to be deemed University, Gaziabad

Abstract

Aim: to analyze autologus dentin graft and its effectiveness in regeneration histologically.


Material and method: Three implants were placed in mandibular anterior region, for which dentin graft was obtained via grade III mobile teeth 35 and 44, they were extracted, cleaned of all the remnants then grinded into particle size of 300-1200 μm in a sterile grinding chamber. Autologous dentin graft was secured using membrane (Alloderm® GBR membrane, Biohorizons, Inc) with auto tracks. At 4 months during second stage, a bone core was obtained for histological examination using 3.2 mm trephine, the core site was then grafted with beta-TCP and was sutured, following which implant prosthesis was given to the patient.


Results: The surgical procedure and the healing was uneventful and patient did not show any discomfort. Histologically, at 4 months, bone grafted section shows the presence of dentin graft along with formation of new mature bone at the junction and vicinity of graft material.


Conclusion: autologous dentin graft shows promising results as a biocompatible regenerative material with low resorption rate and can be used as a substitute for autogenous bone grafts and synthetic bone grafts.

Keywords: Bone graft, Dentin graft, Regeneration, Membrane

Article Details

How to Cite
MAHESH, Lanka et al. Histoligical analysis of ridge augmentation with Autologus Dentin graft and Acellular Dermal matrix: A Descriptive Case Report. Medical Research Archives, [S.l.], v. 12, n. 10, oct. 2024. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/5820>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.18103/mra.v12i10.5820.
ABNT APA BibTeX CBE EndNote - EndNote format (Macintosh & Windows) MLA ProCite - RIS format (Macintosh & Windows) RefWorks Reference Manager - RIS format (Windows only) Turabian
Issue
Vol 12 No 10 (2024): October Issue, Issue 10, VOl.12
Section
Case Reports

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

References

1. Mahesh L, Calvo Guirado JL, Shukla S. et al. Clinical and radiographic findings without the use of bone substitute materials in extraction sockets and delayed implant placement- A case series. J Oral Biol Craniofac Res. 2020;10(2):141-145. doi: 10.1016/j.jobcr.2020.03.011.
2. Schwarz F, Hazar D, Becker K. et al. Short-term outcomes of staged lateral alveolar ridge augmentation using autogenous tooth roots. A prospective controlled clinical study. J Clin Periodontol. 2019;46(9):969-976. doi: 10.1111/jcpe.13161.
3. Calvo- Guirado JL, Montilla AB, De Aza P. et al. Particulated, Extracted Human Teeth Characterization by SEM- EDX Evaluation as a Biomaterial for socket preservation: An in vitro study. Materials 2019;12:380.
4. Yeomans JD, Urist MR. Bone Induction by Decalcified Dentine Implanted into Oral, Osseous and Muscle Tissues. Arch Oral Biol. 1967;12:999–1008. doi: 10.1016/0003-9969(67)90095-7.
5. Bang G, Urist MR. Bone Induction in Excavation Chambers in Matrix of Decalcified Dentin. Arch Surg 1967;94:781–789. doi: 10.1001/archsurg.1967.01330120035008
6. Liu Y, Yu L, Zhang D. et al. Manufacture and preliminary evaluation of acellular tooth roots as allografts for alveolar ridge augmentation. J Biomed Master Res A 2022;110(1):122-130.doi.org/10.1002/jbm.a.37270.
7. Schwarz F, Mihatovic I, Popal-Jensen I. et al. Influence of autoclavation on the efficacy of extracted tooth roots used for vertical alveolar ridge augmentation. J Clin Periodontol. 2019;46(4):502-509. doi: 10.1111/jcpe.13090.
8. kim YK. Bone graft material using teeth. J korean Assoc. Oral maxillofacial surgery. 2012;38:134-138.
9. Butler WT, Ritchie H. The Nature and Functional Significance of Dentin Extracellular Matrix Proteins. Int J Dev Biol 1995;39:169–179.
10. Schmidt-Schultz TH, Schultz M. Intact Growth Factors Are Conserved in the Extracellular Matrix of Ancient Human Bone and Teeth: A Storehouse for the Study of Human Evolution in Health and Disease. Biol Chem. 2005;386:767–776. doi: 10.1515/BC.2005.090. z
11. Finkelman RD, Mohan S, Jennings JC. Et al. Quantitation of Growth Factors IGF-I, SGF/IGF-II, and TGF-Beta in Human Dentin. J Bone Miner Res. 1990;5:717–723. doi: 10.1002/jbmr.5650050708.
12. Kanazirski N, Kanazirska P. Auto-Tooth Bone Graft Material for Reconstruction of Bone Defects in the Oral Region: Case Reports. Folia Med. 2022;64:162–168. doi:0.3897/folmed.64.e59099.
13. Minetti E, Palermo A, Malcangi G. et al. Dentin, Dentin Graft, and Bone Graft: Microscopic and Spectroscopic Analysis. J Funct Biomater 2023;14:272. https://doi.org/ 10.3390/jfb14050272.
14. kim YK, Kim SG, Oh JS. et al. Analysis of the inorganic component of autogenous tooth bone graft material. J Nanosci Nanotechnol 2011;11:7442-7445. doi: 10.1166/jnn.2011.4857.
15. Bindeman I, Hallel G, Nardy C. et al. A Novel Procedure to Process Extracted Teeth for Immediate Grafting of Autogenous Dentin. J Interdiscipl Med Dent Sci 2014;2(6):56-63 DOI: 10.4172/2376-032X.1000154.
16. Kim YK, Lee J, Kim KWB. et al. Analysis of organic components and osteoinductivity in autogenous tooth bone graft material. J Korean Assoc Maxillofac Plast Reconstr Surg 2013;35:353-59. DOI.org/10.14402/jkamprs.2013.35.6.353.
17. Lanka M, Calvo- Guirado JL, Shukla S. et al. Histological study to compare the appropriate particle size of beta tcp for socket preservation. INT J SCI RES 2023;12(2):1-4. DOI: 10.36106/ijsr/3503764.
18. Jeong HR, Hwang JH, Lee JK. Effectiveness of autogenous tooth bone used as a graft material for regeneration of bone in miniature pig. J Korean Assoc Oral Maxillofac Surg. 2011;37:375–379. DOI:org/10.5125/jkaoms.2011.37.5.375.
19. Kim SG, Kim YK, Lim SC. et al. Histomorphometric analysis of bone graft using autogenous tooth bone graft. Implantology. 2011;15:134–141. Doi.org/10.1016/j.0000.2012.04.018
20. Lee JY, Kim YK, Kim SG.et al. Histomorphometric study of sinus bone graft using various graft material. J Dent Rehabil Appl Sci. 2011;27:141–147.
21. Cardaropoli D, Nevins M, Schupbach P. New Bone Formation Using an Extracted Tooth as a Biomaterial: A Case Report with Histologic Evidence. Int J Perio Rest Dent. 2019 Mar/Apr;39(2):157-163. doi: 10.11607/prd.4045.
22. Stumbras A, Kuliesius P, Januzis G. et al. Alveolar Ridge Preservation after Tooth Extraction Using Different Bone Graft Materials and Autologous Platelet Concentrates: a Systematic Review . J Oral Maxillofac Res 2019;10(1):1-14. doi: 10.5037/jomr.2019.10102.
23. Schwarz F, Golubovic V, Mihatovic I. et al. Periodontally diseased tooth roots used for lateral alveolar ridge augmentation. A proof-of-concept study. J Clin Periodontol 2016;43(9):797-803. doi: 10.1111/jcpe.12579.
24. Schwarz F, Hazar D, Becker K. et al Efficacy of autogenous tooth roots for lateral alveolar ridge augmentation and staged implant placement. A prospective controlled clinical study. J Clin Periodontol 2018;45(8):996-1004.
25. Sabitha S, Arun KV, Priya MS. et al. Clinical and histological evaluation of alloderm GBR and BioOss in the treatment of Siebert's class I ridge deficiency. J Indian Soc Periodontol 2008;12(3):73-78. DOI: 10.4103/0972-124X.44099
26. Gharpure AS, Bhatavadekar NB. Clinical Efficacy of Tooth-Bone Graft: A Systematic Review and Risk of Bias Analysis of Randomized Control Trials and Observational Studies. Implant Dent. 2018;27(1):119-134. doi: 10.1097/ID.0000000000000687.