BK virus infection and urothelial carcinoma following kidney transplantation
Main Article Content
Abstract
Although a potential relationship between human polyomavirus BK (BK virus) infection and human malignancy is debated, the role of the BK virus in urothelial carcinoma development in a renal transplant recipient remains unclear. Recent reports suggested novel BK virus strain may play a key role in carcinogenesis. In this review, we report our experiences and outline the latest knowledge about the relationship between BK virus infection and carcinogenesis in urinary tract cancers.
Article Details
How to Cite
OIKAWA, Masaaki.
BK virus infection and urothelial carcinoma following kidney transplantation.
Medical Research Archives, [S.l.], v. 4, n. 5, sep. 2016.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/633>. Date accessed: 26 dec. 2024.
Keywords
BK virus, kidney transplantation, urothelial carcinoma of a ureter graft, SV40
Section
Case Reports
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
Apel, H., Walschburger-Zorn, K., Haberle, L., Wach, S., Engehausen, D. G., & Wullich, B. (2013). De novo malignancies in renal transplant recipients: experience at a single center with 1882 transplant patients over 39 yr. Clin Transplant, 27(1), E30–36. doi: 10.1111/ctr.12050
Barrett, W. L., First, M. R., Aron, B. S., & Penn, I. (1993). Clinical course of malignancies in renal transplant recipients. Cancer, 72(7), 2186–2189.
Birkeland, S. A., Storm, H. H., Lamm, L. U., Barlow, L., Blohme, I., Forsberg, B., et al. (1995). Cancer risk after renal transplantation in the Nordic countries, 1964–1986. Int J Cancer, 60(2), 183–189.
Buzzeo, B. D., Heisey, D. M., & Messing, E. M. (1997). Bladder cancer in renal transplant recipients. Urology, 50(4), 525¬528. doi: 10.1016/S0090-4295(97)00305-1
Chen, C. H., Wen, M. C., Wang, M., Lian, J. D., Cheng, C. H., Wu, M. J., Shu, K. H. (2010). High incidence of malignancy in polyomavirus-associated nephropathy in renal transplant recipients. Transplant Proc, 42(3), 817¬818. doi: 10.1016/j.transproceed.2010.02.068
Chiang, Y. J., Yang, P. S., Wang, H. H., Lin, K. J., Liu, K. L., Chu, S. H., & Hsieh, C. Y. (2012). Urothelial cancer after renal transplantation: an update. Transplant Proc, 44(3), 744–745. doi: 10.1016/j.transproceed.2011.12.073
Drachenberg, C. B., Hirsch, H. H., Ramos, E., & Papadimitriou, J. C. (2005). Polyomavirus disease in renal transplantation - Review of pathological findings and diagnostic methods. Human Pathology, 36(12), 1245-1255. doi: 10.1016/j.humpath.2005.08.009
Egli, A., Binggeli, S., Bodaghi, S., Dumoulin, A., Funk, G. A., Khanna, N., Hirsch, H. H. (2007). Cytomegalovirus and polyomavirus BK posttransplant. Nephrology Dialysis Transplantation, 22, 72–82. doi: 10.1093/ndt/gfm648
Garcia-Espana, A., Salazar, E., Sun, T. T., Wu, X. R., & Pellicer, A. (2005). Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior. Cancer Res, 65(4), 1150–1157. doi: 10.1158/0008-5472.CAN-04-2074
Gardner, S. D., Field, A. M., Coleman, D. V., & Hulme, B. (1971). New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet, 1(7712), 1253–1257.
Huurman, V. A., Baranski, A. G., Groeneveld, J. H., Keizer, K. M., & Schaapherder, A. F. (2008). Transfer of ureteral carcinoma in a transplanted kidney presenting by early stenosis of the proximal ureter. Clin Transplant, 22(6), 847–850. doi: 10.1111/j.1399-0012.2008.00889.x
IARC. (1997). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus/Human Herpesvirus 8. World Health Organization.
Jeffers, L. K., Madden, V., & Webster-Cyriaque, J. (2009). BK virus has tropism for human salivary gland cells in vitro: Implications for transmission. Virology, 394(2), 183–193. doi: 10.1016/j.virol.2009.07.022
Jensen, P., Ulhoi, B. P., & Nielsen, E. H. (1998). Transitional-cell carcinoma in a 25-year-old renal allograft. Nephrol Dial Transplant, 13(12), 3240–3241.
Kao, Y. L., Ou, Y. C., Yang, C. R., Ho, H. C., Su, C. K., & Shu, K. H. (2003). Transitional cell carcinoma in renal transplant recipients. World J Surg, 27(8), 912–916. doi: 10.1007/s00268-003-6954-3
Kenan, D. J., Mieczkowski, P. A., Burger-Calderon, R., Singh, H. K., & Nickeleit, V. (2015). The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome. J Pathol, 237(3), 379–389. doi: 10.1002/path.4584
Li, J. Y., Fang, D., Yong, T. Y., Klebe, S., Juneja, R., & Gleadle, J. M. (2013). Transitional cell carcinoma in a renal allograft with BK nephropathy. Transpl Infect Dis, 15(6), E270–272. doi: 10.1111/tid.12142
Mokos, I., Pasini, J., Stern-Padovan, R., Mrsic, S., & Ries, S. (2006). Conservative surgical treatment of low-grade urothelial carcinoma in the renal allograft recipient: a case report. Transplant Proc, 38(5), 1363–1365. doi: 10.1016/j.transproceed.2006.02.085
Oikawa, M., Hatakeyama, S., Fujita, T., Murakami, R., Hagiwara, K., Narita, T., . ..hyama, C. (2014). BK virus-associated urothelial carcinoma of a ureter graft in a renal transplant recipient: a case report. Transplant Proc, 46(2), 616–619. doi: 10.1016/j.transproceed.2013.09.037
Penn, I. (1990). Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl, 53–62.
Penn, I. (1995). Primary kidney tumors before and after renal transplantation. Transplantation, 59(4), 480–485.
Roberts, I. S., Besarani, D., Mason, P., Turner, G., Friend, P. J., & Newton, R. (2008). Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation. Br J Cancer, 99(9), 1383–1386. doi: 10.1038/sj.bjc.6604711
Rogers, A., Ng, J. K., Glendinning, J., & Rix, D. (2012). The management of transitional cell carcinoma (TCC) in a European regional renal transplant population. BJU Int, 110(2 Pt 2), E34–40. doi: 10.1111/j.1464-410X.2011.10777.x
Saquib, R., Barri, Y. M., Saad, R., Savino, D. A., Rice, K. M., Hays, S. R., & Melton, L. B. (2009). Transitional Cell Carcinoma of Renal Allograft Associated with BK Virus Infection. Dialysis & Transplantation, 38(12), 517–519. doi: 10.1002/dat.20364
Thamboo, T. P., Jeffery, K. J., Friend, P. J., Turner, G. D., & Roberts, I. S. (2007). Urine cytology screening for polyoma virus infection following renal transplantation: the Oxford experience. J Clin Pathol, 60(8), 927–930. doi: 10.1136/jcp.2006.042507
Tognon, M., Corallini, A., Martini, F., Negrini, M., & Barbanti-Brodano, G. (2003). Oncogenic transformation by BK virus and association with human tumors. Oncogene, 22(33), 5192–5200. doi: 10.1038/sj.onc.1206550
Tsaur, I., Karalis, A., Probst, M., Blaheta, R. A., Scheuermann, E. H., Gossmann, J., . ..bermuller, N. (2010). Development of urological cancers in renal transplant recipients: 30-year experience at the Frankfurt Transplant Center. Cancer Sci, 101(11), 2430–2435. doi: 10.1111/j.1349-7006.2010.01676.x
Vajdic, C. M., McDonald, S. P., McCredie, M. R., van Leeuwen, M. T., Stewart, J. H., Law, M., . ..rulich, A. E. (2006). Cancer incidence before and after kidney transplantation. JAMA, 296(23), 2823–2831. doi: 10.1001/jama.296.23.2823
Vervloessem, I., Oyen, R., Vanrenterghem, Y., Van Poppel, H., Van Hover, P., Debakker, G., & Baert, A. L. (1998). Transitional cell carcinoma in a renal allograft. Eur Radiol, 8(6), 936–938. doi: 10.1007/s003300050491
Wang, H. B., Hsieh, H. H., Chen, Y. T., Chiang, C. Y., & Cheng, Y. T. (2002). The outcome of post-transplant transitional cell carcinoma in 10 renal transplant recipients. Clin Transplant, 16(6), 410–413.
Wang, H. H., Liu, K. L., Chu, S. H., Tian, Y. C., Lai, P. C., & Chiang, Y. J. (2009). BK virus infection in association with posttransplant urothelial carcinoma. Transplant Proc, 41(1), 165–166. doi: 10.1016/j.transproceed.2008.08.138
Barrett, W. L., First, M. R., Aron, B. S., & Penn, I. (1993). Clinical course of malignancies in renal transplant recipients. Cancer, 72(7), 2186–2189.
Birkeland, S. A., Storm, H. H., Lamm, L. U., Barlow, L., Blohme, I., Forsberg, B., et al. (1995). Cancer risk after renal transplantation in the Nordic countries, 1964–1986. Int J Cancer, 60(2), 183–189.
Buzzeo, B. D., Heisey, D. M., & Messing, E. M. (1997). Bladder cancer in renal transplant recipients. Urology, 50(4), 525¬528. doi: 10.1016/S0090-4295(97)00305-1
Chen, C. H., Wen, M. C., Wang, M., Lian, J. D., Cheng, C. H., Wu, M. J., Shu, K. H. (2010). High incidence of malignancy in polyomavirus-associated nephropathy in renal transplant recipients. Transplant Proc, 42(3), 817¬818. doi: 10.1016/j.transproceed.2010.02.068
Chiang, Y. J., Yang, P. S., Wang, H. H., Lin, K. J., Liu, K. L., Chu, S. H., & Hsieh, C. Y. (2012). Urothelial cancer after renal transplantation: an update. Transplant Proc, 44(3), 744–745. doi: 10.1016/j.transproceed.2011.12.073
Drachenberg, C. B., Hirsch, H. H., Ramos, E., & Papadimitriou, J. C. (2005). Polyomavirus disease in renal transplantation - Review of pathological findings and diagnostic methods. Human Pathology, 36(12), 1245-1255. doi: 10.1016/j.humpath.2005.08.009
Egli, A., Binggeli, S., Bodaghi, S., Dumoulin, A., Funk, G. A., Khanna, N., Hirsch, H. H. (2007). Cytomegalovirus and polyomavirus BK posttransplant. Nephrology Dialysis Transplantation, 22, 72–82. doi: 10.1093/ndt/gfm648
Garcia-Espana, A., Salazar, E., Sun, T. T., Wu, X. R., & Pellicer, A. (2005). Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior. Cancer Res, 65(4), 1150–1157. doi: 10.1158/0008-5472.CAN-04-2074
Gardner, S. D., Field, A. M., Coleman, D. V., & Hulme, B. (1971). New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet, 1(7712), 1253–1257.
Huurman, V. A., Baranski, A. G., Groeneveld, J. H., Keizer, K. M., & Schaapherder, A. F. (2008). Transfer of ureteral carcinoma in a transplanted kidney presenting by early stenosis of the proximal ureter. Clin Transplant, 22(6), 847–850. doi: 10.1111/j.1399-0012.2008.00889.x
IARC. (1997). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus/Human Herpesvirus 8. World Health Organization.
Jeffers, L. K., Madden, V., & Webster-Cyriaque, J. (2009). BK virus has tropism for human salivary gland cells in vitro: Implications for transmission. Virology, 394(2), 183–193. doi: 10.1016/j.virol.2009.07.022
Jensen, P., Ulhoi, B. P., & Nielsen, E. H. (1998). Transitional-cell carcinoma in a 25-year-old renal allograft. Nephrol Dial Transplant, 13(12), 3240–3241.
Kao, Y. L., Ou, Y. C., Yang, C. R., Ho, H. C., Su, C. K., & Shu, K. H. (2003). Transitional cell carcinoma in renal transplant recipients. World J Surg, 27(8), 912–916. doi: 10.1007/s00268-003-6954-3
Kenan, D. J., Mieczkowski, P. A., Burger-Calderon, R., Singh, H. K., & Nickeleit, V. (2015). The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome. J Pathol, 237(3), 379–389. doi: 10.1002/path.4584
Li, J. Y., Fang, D., Yong, T. Y., Klebe, S., Juneja, R., & Gleadle, J. M. (2013). Transitional cell carcinoma in a renal allograft with BK nephropathy. Transpl Infect Dis, 15(6), E270–272. doi: 10.1111/tid.12142
Mokos, I., Pasini, J., Stern-Padovan, R., Mrsic, S., & Ries, S. (2006). Conservative surgical treatment of low-grade urothelial carcinoma in the renal allograft recipient: a case report. Transplant Proc, 38(5), 1363–1365. doi: 10.1016/j.transproceed.2006.02.085
Oikawa, M., Hatakeyama, S., Fujita, T., Murakami, R., Hagiwara, K., Narita, T., . ..hyama, C. (2014). BK virus-associated urothelial carcinoma of a ureter graft in a renal transplant recipient: a case report. Transplant Proc, 46(2), 616–619. doi: 10.1016/j.transproceed.2013.09.037
Penn, I. (1990). Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl, 53–62.
Penn, I. (1995). Primary kidney tumors before and after renal transplantation. Transplantation, 59(4), 480–485.
Roberts, I. S., Besarani, D., Mason, P., Turner, G., Friend, P. J., & Newton, R. (2008). Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation. Br J Cancer, 99(9), 1383–1386. doi: 10.1038/sj.bjc.6604711
Rogers, A., Ng, J. K., Glendinning, J., & Rix, D. (2012). The management of transitional cell carcinoma (TCC) in a European regional renal transplant population. BJU Int, 110(2 Pt 2), E34–40. doi: 10.1111/j.1464-410X.2011.10777.x
Saquib, R., Barri, Y. M., Saad, R., Savino, D. A., Rice, K. M., Hays, S. R., & Melton, L. B. (2009). Transitional Cell Carcinoma of Renal Allograft Associated with BK Virus Infection. Dialysis & Transplantation, 38(12), 517–519. doi: 10.1002/dat.20364
Thamboo, T. P., Jeffery, K. J., Friend, P. J., Turner, G. D., & Roberts, I. S. (2007). Urine cytology screening for polyoma virus infection following renal transplantation: the Oxford experience. J Clin Pathol, 60(8), 927–930. doi: 10.1136/jcp.2006.042507
Tognon, M., Corallini, A., Martini, F., Negrini, M., & Barbanti-Brodano, G. (2003). Oncogenic transformation by BK virus and association with human tumors. Oncogene, 22(33), 5192–5200. doi: 10.1038/sj.onc.1206550
Tsaur, I., Karalis, A., Probst, M., Blaheta, R. A., Scheuermann, E. H., Gossmann, J., . ..bermuller, N. (2010). Development of urological cancers in renal transplant recipients: 30-year experience at the Frankfurt Transplant Center. Cancer Sci, 101(11), 2430–2435. doi: 10.1111/j.1349-7006.2010.01676.x
Vajdic, C. M., McDonald, S. P., McCredie, M. R., van Leeuwen, M. T., Stewart, J. H., Law, M., . ..rulich, A. E. (2006). Cancer incidence before and after kidney transplantation. JAMA, 296(23), 2823–2831. doi: 10.1001/jama.296.23.2823
Vervloessem, I., Oyen, R., Vanrenterghem, Y., Van Poppel, H., Van Hover, P., Debakker, G., & Baert, A. L. (1998). Transitional cell carcinoma in a renal allograft. Eur Radiol, 8(6), 936–938. doi: 10.1007/s003300050491
Wang, H. B., Hsieh, H. H., Chen, Y. T., Chiang, C. Y., & Cheng, Y. T. (2002). The outcome of post-transplant transitional cell carcinoma in 10 renal transplant recipients. Clin Transplant, 16(6), 410–413.
Wang, H. H., Liu, K. L., Chu, S. H., Tian, Y. C., Lai, P. C., & Chiang, Y. J. (2009). BK virus infection in association with posttransplant urothelial carcinoma. Transplant Proc, 41(1), 165–166. doi: 10.1016/j.transproceed.2008.08.138