Insights from twin Sudden Infant Death Syndrome studies could reveal an aetiopathogenetic pathway to sudden infant death through immunopathology
Main Article Content
Abstract
Twins represent an interesting and unique resource to help unravel the mystery of sudden Infant death syndrome (SIDS). This is because of some outstanding coincidental findings: these include the increased susceptibility to both SIDS and infectious diseases. Susceptibility resides in their inadequate, immature immune system and contributing factors associated with prematurity, such as not benefiting from the protective advantages of transplacental maternal antibodies and not usually receiving the protection of colostrum and/or breast milk. The review examines infection and pseudo-infection (i.e., vaccination) in the context of a disadvantaged, immature infant immune system and how this could contribute as a cause of SIDS through the effects of immune perturbation via hyperimmunization. In this respect, the potential adverse effects of exposure to multitudinous vaccine target antigens in the first year of life is reviewed.
Keywords:
SIDS: twins, infection, pseudo-infection, vaccines, Th1 response, Th2 response, mucosal immunity, immunopathology
Article Details
How to Cite
GOLDWATER, Paul N..
Insights from twin Sudden Infant Death Syndrome studies could reveal an aetiopathogenetic pathway to sudden infant death through immunopathology.
Medical Research Archives, [S.l.], v. 13, n. 7, july 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6787>. Date accessed: 08 dec. 2025.
doi: https://doi.org/10.18103/mra.v13i7.6787.
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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