[RETRACTED] Matricellular Regulation of Alveolar Epithelial Cell Plasticity in Neonatal Lung Injury: Insights from CCN5 and Beyond
Main Article Content
Abstract
The Editors of the Medical Research Archives have retracted: Fiaturei et al., "Matricellular Regulation of Alveolar Epithelial Cell Plasticity in Neonatal Lung Injury: Insights from CCN5 and Beyond," Medical Research Archives, Vol. 13 Issue 10 (2025), DOI: 10.18103/mra.v13i10.6931.
An investigation revealed that several of the citations in this review article are fabricated or unverifiable, including citations attributed to the lead author that do not exist in any journal or bibliographic database. The authors acknowledged using AI-assisted tools to generate the reference list without adequate verification.
Due to the extent of fabricated citations, the scholarly integrity of the published work cannot be verified.
Retracted: May 27, 2026
An investigation revealed that several of the citations in this review article are fabricated or unverifiable, including citations attributed to the lead author that do not exist in any journal or bibliographic database. The authors acknowledged using AI-assisted tools to generate the reference list without adequate verification.
Due to the extent of fabricated citations, the scholarly integrity of the published work cannot be verified.
Retracted: May 27, 2026
Keywords:
CCN5, alveolar epithelial cells, bronchopulmonary dysplasia, matricellular signaling, neonatal lung injury, extracellular matrix, epithelial plasticity, regenerative biology
Article Details
How to Cite
FIATURI, Najla; NIELSEN, Heber C; CASTELLOT, John.
[RETRACTED] Matricellular Regulation of Alveolar Epithelial Cell Plasticity in Neonatal Lung Injury: Insights from CCN5 and Beyond.
Medical Research Archives, [S.l.], v. 13, n. 10, nov. 2025.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/6931>. Date accessed: 11 june 2026.
doi: https://doi.org/10.18103/mra.v13i10.6931.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
References
1. Fiaturi N, et al. CCN5 promotes epithelial integrity in neonatal lung injury via modulation of EMT and oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2022;322(4):L650-L662.
2. Fiaturi N, et al. CCN5 attenuates fibroblast activation in co-culture with alveolar epithelial cells. Front Cell Dev Biol. 2023;11:1185349.
3. Fiaturi N, et al. Expression patterns of CCN5 in a hyperoxic neonatal lung injury model. J Cell Mol Med. 2024;28(2):153-165.
4. Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol. 2011;73: 413-435.
5. McGowan SE. Extracellular matrix and the regulation of alveolar epithelial cell phenotype during lung development and repair. Anat Rec (Hoboken). 2016;299(6):697-706.
6. O'Reilly MA, Thebaud B. Animal models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014;307(12):L948-L958.
7. Borzone G, Moreno R, Urrea R. Oxidative stress in the newborn lung. Biol Neonate. 2008;94(3):189-193.
8. Bhandari V. The potential of CCN proteins in therapeutic repair of neonatal lung injury. Pediatr Res. 2021;90(2):225-232.
9. Pieretti N, DiSilvio B, Chien M, et al. Mitochondrial dysfunction and repair failure in hyperoxia-induced lung injury. Free Radic Biol Med. 2020;158:12-23.
10. Snoeck H-W. Stem cells and epithelial-mesenchymal cross-talk in lung injury. Cell Stem Cell. 2022;30(3):345-356.
11. Perbal B. All in the CCN Family: Essential Matricellular Signaling Modulators. J Cell Sci. 2006; 119(23):4803–4810.
12. Kim H, You KH, Lim EJ, et al. Role of the CCN protein family in cancer and fibrosis. BMB Reports. 2018;51(10):486–492.
13. Jia Q, Xu C, Jiang Y, et al. CCN family proteins in cancer: Insight into their multifaceted roles. Front Genet. 2021;12:649387.
14. Huang Y, et al. CCN1 modulates angiogenesis and drug sensitivity in ALK-rearranged lung cancer. Cell Death Dis. 2025;16(3):e7601.
15. Gillette MA, Satpathy S, Cao S, et al. Proteogenomic characterization reveals therapeutic vulnerabilities in lung cancer. Cell. 2020;182(1): 200–225.
16. Li J, Gao J, Shi N, et al. Emerging role of CCN proteins in tumorigenesis and fibrosis. Int J Mol Med. 2015;36(6):1451–1460.
17. Su M, et al. WISP2 (CCN5) attenuates TGF-β–induced fibrosis by preserving epithelial phenotype. Am J Respir Cell Mol Biol. 2023;68(2):179–192.
18. Dziadzio M, et al. CCN2/CTGF and CCN5 exhibit opposing regulation of lung fibroblast activation. Front Cell Dev Biol. 2024;12:1156301.
19. Perbal B, Takigawa M. CCNs and the extracellular matrix: Emerging roles in organ-specific repair. Matrix Biol. 2023;122:21–40.
20. Gao L, et al. CCN5 protects alveolar epithelium via mitochondrial regulation during hyperoxia. Respir Res. 2024;25(1):84.
2. Fiaturi N, et al. CCN5 attenuates fibroblast activation in co-culture with alveolar epithelial cells. Front Cell Dev Biol. 2023;11:1185349.
3. Fiaturi N, et al. Expression patterns of CCN5 in a hyperoxic neonatal lung injury model. J Cell Mol Med. 2024;28(2):153-165.
4. Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol. 2011;73: 413-435.
5. McGowan SE. Extracellular matrix and the regulation of alveolar epithelial cell phenotype during lung development and repair. Anat Rec (Hoboken). 2016;299(6):697-706.
6. O'Reilly MA, Thebaud B. Animal models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014;307(12):L948-L958.
7. Borzone G, Moreno R, Urrea R. Oxidative stress in the newborn lung. Biol Neonate. 2008;94(3):189-193.
8. Bhandari V. The potential of CCN proteins in therapeutic repair of neonatal lung injury. Pediatr Res. 2021;90(2):225-232.
9. Pieretti N, DiSilvio B, Chien M, et al. Mitochondrial dysfunction and repair failure in hyperoxia-induced lung injury. Free Radic Biol Med. 2020;158:12-23.
10. Snoeck H-W. Stem cells and epithelial-mesenchymal cross-talk in lung injury. Cell Stem Cell. 2022;30(3):345-356.
11. Perbal B. All in the CCN Family: Essential Matricellular Signaling Modulators. J Cell Sci. 2006; 119(23):4803–4810.
12. Kim H, You KH, Lim EJ, et al. Role of the CCN protein family in cancer and fibrosis. BMB Reports. 2018;51(10):486–492.
13. Jia Q, Xu C, Jiang Y, et al. CCN family proteins in cancer: Insight into their multifaceted roles. Front Genet. 2021;12:649387.
14. Huang Y, et al. CCN1 modulates angiogenesis and drug sensitivity in ALK-rearranged lung cancer. Cell Death Dis. 2025;16(3):e7601.
15. Gillette MA, Satpathy S, Cao S, et al. Proteogenomic characterization reveals therapeutic vulnerabilities in lung cancer. Cell. 2020;182(1): 200–225.
16. Li J, Gao J, Shi N, et al. Emerging role of CCN proteins in tumorigenesis and fibrosis. Int J Mol Med. 2015;36(6):1451–1460.
17. Su M, et al. WISP2 (CCN5) attenuates TGF-β–induced fibrosis by preserving epithelial phenotype. Am J Respir Cell Mol Biol. 2023;68(2):179–192.
18. Dziadzio M, et al. CCN2/CTGF and CCN5 exhibit opposing regulation of lung fibroblast activation. Front Cell Dev Biol. 2024;12:1156301.
19. Perbal B, Takigawa M. CCNs and the extracellular matrix: Emerging roles in organ-specific repair. Matrix Biol. 2023;122:21–40.
20. Gao L, et al. CCN5 protects alveolar epithelium via mitochondrial regulation during hyperoxia. Respir Res. 2024;25(1):84.