Title: Contrast enhanced abdominal computerised tomography using a reduced volume of high concentration iodinated contrast medium to achieve a dose reduction.

Main Article Content

Jamal Ali Abdulkarim http://orcid.org/0000-0001-5510-4817 David Ian Bailey http://orcid.org/0000-0002-4899-9912

Abstract

Aim:  We aim to evaluate whether a reduced volume of high concentration iodinated contrast material could be used in abdominal CT to achieve an iodine load reduction without adversely affecting image quality.

Materials and methods:  150 portal venous phase abdominal CT investigations were reviewed retrospectively and the degree of visceral opacification measured using the liver as representative.   Two groups of patients were studied whom received either either 100 ml of Optiray 300 mg/ml or 75 ml of Optiray 350 mg/ml intravenous contrast material prior to the CT.

Results:  The iodine dose was lower in the 75 ml Optiray 350 group (26.25 g group) than the 100 ml Optiray 300 group (30 g group).  Mean CT density of liver parenchyma was statistically significantly lower in the 26.25 g group 80 HU 95 % CI (78.2, 82.0) vs the 30 g group 86.6 HU 95 % CI (83.7, 89.6). Both protocols achieved diagnostically acceptable images with liver opacification above 50 HU in at least 95%.  The 30 g group achieved liver opacification above 50 HU in 95 % of cases, the 26.25 g group achieved liver opacification above 50 HU in 98.5%.

Conclusion:  A modest reduction in the dose of administered intravenous contrast may be achieved  by mildly reducing the mean visceral opacification but without adversely affecting the diagnostic value of the images obtained.

Article Details

How to Cite
ABDULKARIM, Jamal Ali; BAILEY, David Ian. Title: Contrast enhanced abdominal computerised tomography using a reduced volume of high concentration iodinated contrast medium to achieve a dose reduction.. Medical Research Archives, [S.l.], v. 4, n. 8, dec. 2016. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/886>. Date accessed: 30 jan. 2023.
Keywords
Iodinated contrast, dose reduction, CT
Section
Articles

References

1.Morcos SK, Thomsen HS, Webb JA. Contrast media safety committee of the European Society or urogenital radiology (ESUR). Contrast media induced nephrotoxicity: a consensus report. Eur Radiol 1999;9:1602-13.

2.From AM, Batholmai AM, Williams AW, Cha SS, McDonald FS. Mortality associated with nephropathy after radiographic contrast exposure. Mayo Clin Proc 2008;83:1095-100.

3.Brenner DJ, Hall EJ. Computed tomography – An increasing source of radiation exposure. N Engl J Med 2007;357:2277-2284.

4.Goble EW, Abdulkarim JA. CT pulmonary angiography using a reduced volume of high-concentration iodinated contrast medium and multiphasic injection to achieve dose reduction. Clin Rad 2014;69:36-40.

5.Fleischmann D. Present and future trends in multiple detector-row CT applications: CT angiography. European Radiology 2002;12[sup2]:S11-16.

6.Dean PB, Volante MR, Mahoney JA. Hepatic CT contrast enhancement: effect of dose, duration of infusion and time elapsed following infusion. Investigative Radiology 1980;15:158-61.

7.Brink JA, Heiken JP, Forman HP, Sagel SS, Molina PL, Brown PC. Hepatic spiral CT: reduction of dose of intravenous contrast material. Radiology 1995;197:83-88
8.

Similar Articles

You may also start an advanced similarity search for this article.